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The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless.

Rijsewijk F, Schuermann M, Wagenaar E, Parren P, Weigel D, Nusse R. Rijsewijk F, et al. Among authors: parren p. Cell. 1987 Aug 14;50(4):649-57. doi: 10.1016/0092-8674(87)90038-9. Cell. 1987. PMID: 3111720

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Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen.

Wang G, de Jong RN, van den Bremer ET, Beurskens FJ, Labrijn AF, Ugurlar D, Gros P, Schuurman J, Parren PW, Heck AJ. Wang G, et al. Among authors: parren pw. Mol Cell. 2016 Jul 7;63(1):135-45. doi: 10.1016/j.molcel.2016.05.016. Epub 2016 Jun 16. Mol Cell. 2016. PMID: 27320199

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Contrasting IgG structures reveal extreme asymmetry and flexibility.

Saphire EO, Stanfield RL, Crispin MD, Parren PW, Rudd PM, Dwek RA, Burton DR, Wilson IA. Saphire EO, et al. J Mol Biol. 2002 May 24;319(1):9-18. doi: 10.1016/S0022-2836(02)00244-9. J Mol Biol. 2002. PMID: 12051932

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Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.

Labrijn AF, Meesters JI, de Goeij BE, van den Bremer ET, Neijssen J, van Kampen MD, Strumane K, Verploegen S, Kundu A, Gramer MJ, van Berkel PH, van de Winkel JG, Schuurman J, Parren PW. Labrijn AF, et al. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5145-50. doi: 10.1073/pnas.1220145110. Epub 2013 Mar 11. Proc Natl Acad Sci U S A. 2013. PMID: 23479652 Free PMC article.

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Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength.

Labrijn AF, Rispens T, Meesters J, Rose RJ, den Bleker TH, Loverix S, van den Bremer ET, Neijssen J, Vink T, Lasters I, Aalberse RC, Heck AJ, van de Winkel JG, Schuurman J, Parren PW. Labrijn AF, et al. J Immunol. 2011 Sep 15;187(6):3238-46. doi: 10.4049/jimmunol.1003336. Epub 2011 Aug 12. J Immunol. 2011. PMID: 21841137

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A novel label-free cell-based assay technology using biolayer interferometry.

Verzijl D, Riedl T, Parren PWHI, Gerritsen AF. Verzijl D, et al. Among authors: parren pwhi. Biosens Bioelectron. 2017 Jan 15;87:388-395. doi: 10.1016/j.bios.2016.08.095. Epub 2016 Aug 28. Biosens Bioelectron. 2017. PMID: 27589401

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Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange.

van den Bremer ETJ, Labrijn AF, van den Boogaard R, Priem P, Scheffler K, Melis JPM, Schuurman J, Parren PWHI, de Jong RN. van den Bremer ETJ, et al. Among authors: parren pwhi. Anal Chem. 2017 Oct 17;89(20):10873-10882. doi: 10.1021/acs.analchem.7b02543. Epub 2017 Oct 2. Anal Chem. 2017. PMID: 28922593

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Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry.

Wang G, de Jong RN, van den Bremer ETJ, Parren PWHI, Heck AJR. Wang G, et al. Anal Chem. 2017 May 2;89(9):4793-4797. doi: 10.1021/acs.analchem.6b05129. Epub 2017 Apr 13. Anal Chem. 2017. PMID: 28383250 Free PMC article.

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Tandem Native Mass-Spectrometry on Antibody-Drug Conjugates and Submillion Da Antibody-Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector.

Dyachenko A, Wang G, Belov M, Makarov A, de Jong RN, van den Bremer ET, Parren PW, Heck AJ. Dyachenko A, et al. Anal Chem. 2015 Jun 16;87(12):6095-102. doi: 10.1021/acs.analchem.5b00788. Epub 2015 May 27. Anal Chem. 2015. PMID: 25978613

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In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap.

Rosati S, van den Bremer ET, Schuurman J, Parren PW, Kamerling JP, Heck AJ. Rosati S, et al. Among authors: parren pw. MAbs. 2013 Nov-Dec;5(6):917-24. doi: 10.4161/mabs.26282. Epub 2013 Aug 28. MAbs. 2013. PMID: 23995615 Free PMC article.

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