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β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.
Smartt HJ, Greenhough A, Ordóñez-Morán P, Talero E, Cherry CA, Wallam CA, Parry L, Al Kharusi M, Roberts HR, Mariadason JM, Clarke AR, Huelsken J, Williams AC, Paraskeva C. Smartt HJ, et al. Among authors: parry l. Gut. 2012 Sep;61(9):1306-14. doi: 10.1136/gutjnl-2011-300817. Epub 2011 Nov 14. Gut. 2012. PMID: 22082586
Cited1 deficiency suppresses intestinal tumorigenesis.
Méniel V, Song F, Phesse T, Young M, Poetz O, Parry L, Jenkins JR, Williams GT, Dunwoodie SL, Watson A, Clarke AR. Méniel V, et al. Among authors: parry l. PLoS Genet. 2013;9(8):e1003638. doi: 10.1371/journal.pgen.1003638. Epub 2013 Aug 1. PLoS Genet. 2013. PMID: 23935526 Free PMC article.
Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.
May S, Owen H, Phesse TJ, Greenow KR, Jones GR, Blackwood A, Cook PC, Towers C, Gallimore AM, Williams GT, Stürzl M, Britzen-Laurent N, Sansom OJ, MacDonald AS, Bird AP, Clarke AR, Parry L. May S, et al. Among authors: parry l. J Pathol. 2018 Jul;245(3):270-282. doi: 10.1002/path.5074. Epub 2018 May 16. J Pathol. 2018. PMID: 29603746 Free PMC article.
E-cadherin can limit the transforming properties of activating β-catenin mutations.
Huels DJ, Ridgway RA, Radulescu S, Leushacke M, Campbell AD, Biswas S, Leedham S, Serra S, Chetty R, Moreaux G, Parry L, Matthews J, Song F, Hedley A, Kalna G, Ceteci F, Reed KR, Meniel VS, Maguire A, Doyle B, Söderberg O, Barker N, Watson A, Larue L, Clarke AR, Sansom OJ. Huels DJ, et al. Among authors: parry l. EMBO J. 2015 Sep 14;34(18):2321-33. doi: 10.15252/embj.201591739. Epub 2015 Aug 3. EMBO J. 2015. PMID: 26240067 Free PMC article.
Epigenetic silencing of serine protease HTRA1 drives polyploidy.
Schmidt N, Irle I, Ripkens K, Lux V, Nelles J, Johannes C, Parry L, Greenow K, Amir S, Campioni M, Baldi A, Oka C, Kawaichi M, Clarke AR, Ehrmann M. Schmidt N, et al. Among authors: parry l. BMC Cancer. 2016 Jul 7;16:399. doi: 10.1186/s12885-016-2425-8. BMC Cancer. 2016. PMID: 27388476 Free PMC article.
319 results