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Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells.
Huang WK, Wong SZH, Pather SR, Nguyen PTT, Zhang F, Zhang DY, Zhang Z, Lu L, Fang W, Chen L, Fernandes A, Su Y, Song H, Ming GL. Huang WK, et al. Among authors: pather sr. Cell Stem Cell. 2021 Sep 2;28(9):1657-1670.e10. doi: 10.1016/j.stem.2021.04.006. Epub 2021 May 6. Cell Stem Cell. 2021. PMID: 33961804 Free PMC article.
Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation.
Qian X, Su Y, Adam CD, Deutschmann AU, Pather SR, Goldberg EM, Su K, Li S, Lu L, Jacob F, Nguyen PTT, Huh S, Hoke A, Swinford-Jackson SE, Wen Z, Gu X, Pierce RC, Wu H, Briand LA, Chen HI, Wolf JA, Song H, Ming GL. Qian X, et al. Among authors: pather sr. Cell Stem Cell. 2020 May 7;26(5):766-781.e9. doi: 10.1016/j.stem.2020.02.002. Epub 2020 Mar 5. Cell Stem Cell. 2020. PMID: 32142682 Free PMC article.
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium.
Jacob F, Pather SR, Huang WK, Zhang F, Wong SZH, Zhou H, Cubitt B, Fan W, Chen CZ, Xu M, Pradhan M, Zhang DY, Zheng W, Bang AG, Song H, Carlos de la Torre J, Ming GL. Jacob F, et al. Among authors: pather sr. Cell Stem Cell. 2020 Dec 3;27(6):937-950.e9. doi: 10.1016/j.stem.2020.09.016. Epub 2020 Sep 21. Cell Stem Cell. 2020. PMID: 33010822 Free PMC article.
Podocalyxin-Like Protein 1 Regulates Pluripotency through the Cholesterol Biosynthesis Pathway.
Chen WJ, Huang WK, Pather SR, Chang WF, Sung LY, Wu HC, Liao MY, Lee CC, Wu HH, Wu CY, Liao KS, Lin CY, Yang SC, Lin H, Lai PL, Ng CH, Hu CM, Chen IC, Chuang CH, Lai CY, Lin PY, Lee YC, Schuyler SC, Schambach A, Lu FL, Lu J. Chen WJ, et al. Among authors: pather sr. Adv Sci (Weinh). 2022 Nov 14;10(1):e2205451. doi: 10.1002/advs.202205451. Online ahead of print. Adv Sci (Weinh). 2022. PMID: 36373710 Free PMC article.
Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality.
Zimmerlin L, Park TS, Huo JS, Verma K, Pather SR, Talbot CC Jr, Agarwal J, Steppan D, Zhang YW, Considine M, Guo H, Zhong X, Gutierrez C, Cope L, Canto-Soler MV, Friedman AD, Baylin SB, Zambidis ET. Zimmerlin L, et al. Among authors: pather sr. Development. 2016 Dec 1;143(23):4368-4380. doi: 10.1242/dev.138982. Epub 2016 Sep 22. Development. 2016. PMID: 27660325 Free PMC article.
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons.
Santhosh Kumar S, Naseri NN, Pather SR, Hallacli E, Ndayisaba A, Buenaventura C, Acosta K, Roof J, Fazelinia H, Spruce LA, Luk K, Khurana V, Rhoades E, Shalem O. Santhosh Kumar S, et al. Among authors: pather sr. Sci Adv. 2024 Feb 9;10(6):eadj4767. doi: 10.1126/sciadv.adj4767. Epub 2024 Feb 9. Sci Adv. 2024. PMID: 38335281 Free PMC article.
A subpopulation of lipogenic brown adipocytes drives thermogenic memory.
Lundgren P, Sharma PV, Dohnalová L, Coleman K, Uhr GT, Kircher S, Litichevskiy L, Bahnsen K, Descamps HC, Demetriadou C, Chan J, Chellappa K, Cox TO, Heyman Y, Pather SR, Shoffler C, Petucci C, Shalem O, Raj A, Baur JA, Snyder NW, Wellen KE, Levy M, Seale P, Li M, Thaiss CA. Lundgren P, et al. Among authors: pather sr. Nat Metab. 2023 Oct;5(10):1691-1705. doi: 10.1038/s42255-023-00893-w. Epub 2023 Oct 2. Nat Metab. 2023. PMID: 37783943