Diplacone Isolated from Paulownia tomentosa Mature Fruit Induces Ferroptosis-Mediated Cell Death through Mitochondrial Ca(2+) Influx and Mitochondrial Permeability Transition.
Kang MJ, Ryu HW, Oh ES, Song YN, Huh YH, Park JY, Oh SM, Lee SY, Park YJ, Kim DY, Ro H, Hong ST, Lee SU, Moon DO, Kim MO.
Kang MJ, et al.
Int J Mol Sci. 2023 Apr 11;24(8):7057. doi: 10.3390/ijms24087057.
Int J Mol Sci. 2023.
PMID: 37108220
Free PMC article.
Ferroptosis is characterized by the depletion of glutathione (GSH)/glutathione peroxidase-4 (GPx4) and iron-dependent lipid peroxidation. Diplacone (DP), a geranylated flavonoid compound found in Paulownia tomentosa fruit, has been identified to have anti-inflammato …
Ferroptosis is characterized by the depletion of glutathione (GSH)/glutathione peroxidase-4 (GPx4) and iron-dependent lipid peroxidation. Di …