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Proliferation of human malignant astrocytomas is dependent on Ras activation.
Guha A, Feldkamp MM, Lau N, Boss G, Pawson A. Guha A, et al. Among authors: pawson a. Oncogene. 1997 Dec 4;15(23):2755-65. doi: 10.1038/sj.onc.1201455. Oncogene. 1997. PMID: 9419966
Stimulation of PDGFR's and EGFR's induced tyrosine phosphorylation of the Shc adaptor protein and its association with Grb2, suggesting a mechanism by which Ras may be activated in human malignant astrocytoma cells. ...
Stimulation of PDGFR's and EGFR's induced tyrosine phosphorylation of the Shc adaptor protein and its association with Grb2, suggesting a
Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase).
Zanke B, Suzuki H, Kishihara K, Mizzen L, Minden M, Pawson A, Mak TW. Zanke B, et al. Among authors: pawson a. Eur J Immunol. 1992 Jan;22(1):235-9. doi: 10.1002/eji.1830220134. Eur J Immunol. 1992. PMID: 1530918
We report here, the identification of a new gene with a tyrosine phosphatase domain (EC 3.1.3.48) which is expressed exclusively in thymus and spleen. A cDNA of 2760 bp encodes a 339-amino acid, intracellular, single-domain tyrosine phosphatase. When e …
We report here, the identification of a new gene with a tyrosine phosphatase domain (EC 3.1.3.48) which is expressed exclusive …
In vitro transformation of osteoblasts: putative formation of osteosarcoma in vitro.
Cogliano A, Mock D, Birek C, Pawson A, Tenenbaum HC. Cogliano A, et al. Among authors: pawson a. Bone. 1987;8(5):299-304. doi: 10.1016/8756-3282(87)90006-8. Bone. 1987. PMID: 2827712
The study of bone cancer has been difficult in part due to a lack of appropriate in vitro osteosarcoma model systems. The development of such systems is essential if a clearer understanding of the biology of and mechanisms behind the formation and progression of bon …
The study of bone cancer has been difficult in part due to a lack of appropriate in vitro osteosarcoma model systems. The development …
Characterization of a monoclonal antibody directed against the phosphotyrosine kinase p56lck, in human T cells.
Ansotegui IJ, Chow SC, Jeddi-Tehrani M, Meloche S, Pawson A, Sekaly RP, Mak TW, Wigzell H. Ansotegui IJ, et al. Among authors: pawson a. Scand J Immunol. 1991 Apr;33(4):375-80. doi: 10.1111/j.1365-3083.1991.tb01784.x. Scand J Immunol. 1991. PMID: 2017663
A monoclonal antibody (anti-p56lck) was generated against a fusion protein containing the residues 145-509 of the human p56lck, a lymphocyte-specific membrane-associated protein tyrosine kinase. ...We have produced a monoclonal antibody which recognize
A monoclonal antibody (anti-p56lck) was generated against a fusion protein containing the residues 145-509 of the human p56lck
A single amino acid substitution in transmembrane helix VI results in overexpression of the human GnRH receptor.
Myburgh DB, Pawson AJ, Davidson JS, Flanagan CA, Millar RP, Hapgood JP. Myburgh DB, et al. Among authors: pawson aj. Eur J Endocrinol. 1998 Oct;139(4):438-47. doi: 10.1530/eje.0.1390438. Eur J Endocrinol. 1998. PMID: 9820623
OBJECTIVE: Construction of constitutively active mutants of the GnRH receptor, a member of the G-protein coupled receptor superfamily, would facilitate investigation of the mechanism of receptor activation. ...Thus a single amino acid mutation in transmembrane helix …
OBJECTIVE: Construction of constitutively active mutants of the GnRH receptor, a member of the G-protein coupled receptor superfamily …
Mammalian type I gonadotropin-releasing hormone receptors undergo slow, constitutive, agonist-independent internalization.
Pawson AJ, Faccenda E, Maudsley S, Lu ZL, Naor Z, Millar RP. Pawson AJ, et al. Endocrinology. 2008 Mar;149(3):1415-22. doi: 10.1210/en.2007-1159. Epub 2007 Nov 26. Endocrinology. 2008. PMID: 18039780
The mammalian type I GnRH receptors are unique among the rhodopsin-like G protein-coupled receptors because they lack a cytoplasmic carboxyl-terminal tail. ...We demonstrate that mammalian type I GnRH receptors exhibit a low level of constitutive agonist-independent …
The mammalian type I GnRH receptors are unique among the rhodopsin-like G protein-coupled receptors because they lack a cytoplasmic c …
Elucidation of mechanisms of the reciprocal cross talk between gonadotropin-releasing hormone and prostaglandin receptors.
Naidich M, Shterntal B, Furman R, Pawson AJ, Jabbour HN, Morgan K, Millar RP, Jia J, Tomic M, Stojilkovic S, Stern N, Naor Z. Naidich M, et al. Among authors: pawson aj. Endocrinology. 2010 Jun;151(6):2700-12. doi: 10.1210/en.2009-1335. Epub 2010 Apr 14. Endocrinology. 2010. PMID: 20392830
GnRH stimulates arachidonic acid (AA) release from LbetaT2 gonadotrope cells via the Ca(2+)-independent phospholipase A(2) (iPLA(2)) and not via the more common Ca(2+)-dependent cytosolic phospholipase A(2)alpha (cPLA(2)alpha). AA release was followed by a ma …
GnRH stimulates arachidonic acid (AA) release from LbetaT2 gonadotrope cells via the Ca(2+)-independent phospholipase A(2) (iPLA(2)) …
Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated.
Morgan K, Sellar R, Pawson AJ, Lu ZL, Millar RP. Morgan K, et al. Among authors: pawson aj. Endocrinology. 2006 Nov;147(11):5041-51. doi: 10.1210/en.2006-0222. Epub 2006 Aug 17. Endocrinology. 2006. PMID: 16916952
New data for cattle (Bos taurus) indicates a gene encoding GnRH-II decapeptide possessing arginine (codon: CGG) rather than tryptophan (TGG) at position three in the mature peptide. ...A premature stop codon (TGA) replaces the expected tryptophan codon at position s …
New data for cattle (Bos taurus) indicates a gene encoding GnRH-II decapeptide possessing arginine (codon: CGG) rather than tryptopha …
Identification of Ser153 in ICL2 of the gonadotropin-releasing hormone (GnRH) receptor as a phosphorylation-independent site for inhibition of Gq coupling.
Shacham S, Cheifetz MN, Fridkin M, Pawson AJ, Millar RP, Naor Z. Shacham S, et al. Among authors: pawson aj. J Biol Chem. 2005 Aug 12;280(32):28981-8. doi: 10.1074/jbc.M500312200. Epub 2005 Jun 17. J Biol Chem. 2005. PMID: 15964850
Type I gonadotropin-releasing hormone (GnRH) receptor (GnRHR) is unique among mammalian G-protein-coupled receptors (GPCRs) in lacking a C-terminal tail, which is involved in desensitization in GPCRs. ...The data indicate that ICL2 harbors an inhibitory domain, such that e …
Type I gonadotropin-releasing hormone (GnRH) receptor (GnRHR) is unique among mammalian G-protein-coupled receptors (GPCRs) in lacking a
Changes to gonadotropin-releasing hormone (GnRH) receptor extracellular loops differentially affect GnRH analog binding and activation: evidence for distinct ligand-stabilized receptor conformations.
Pfleger KD, Pawson AJ, Millar RP. Pfleger KD, et al. Among authors: pawson aj. Endocrinology. 2008 Jun;149(6):3118-29. doi: 10.1210/en.2008-0002. Epub 2008 Mar 20. Endocrinology. 2008. PMID: 18356273
By investigating chimeric receptors that combine regions of mammalian and nonmammalian GnRH receptors, a greater understanding of how different domains influence ligand binding and receptor activation can be achieved. ...We demonstrate examples of GnRH receptor gain-of-fun …
By investigating chimeric receptors that combine regions of mammalian and nonmammalian GnRH receptors, a greater understanding of how …
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