Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1983 1
1984 1
1991 1
1993 1
1994 3
1995 7
1996 2
1997 4
1998 4
1999 7
2000 2
2001 1
2002 4
2003 5
2004 5
2005 9
2006 10
2007 9
2008 13
2009 7
2010 14
2011 12
2012 16
2013 23
2014 15
2015 11
2016 16
2017 20
2018 15
2019 26
2020 21
2021 27
2022 13
2023 18
2024 10

Text availability

Article attribute

Article type

Publication date

Search Results

322 results

Results by year

Filters applied: . Clear all
Page 1
PCM1::JAK2 fusion associates with an atypical form of mycosis fungoides.
Rodriguez-Sevilla JJ, Salido M, Rodriguez-Rivera M, Sanchez-Gonzalez B, Gallardo F, Pujol RM, Colomo L. Rodriguez-Sevilla JJ, et al. Virchows Arch. 2022 Dec;481(6):967-973. doi: 10.1007/s00428-022-03372-x. Epub 2022 Jul 4. Virchows Arch. 2022. PMID: 35786767 Review.
We report the case of a 23-year-old woman diagnosed of atypical MF carrying isolated PCM1::JAK2 fusion and eosinophilia. The disease was refractory to common treatments and progressed increasing the number of large CD30 positive T-cells. ...Described cases shared similar c …
We report the case of a 23-year-old woman diagnosed of atypical MF carrying isolated PCM1::JAK2 fusion and eosinophilia. The disease …
PCM1 labeling reveals myonuclear and nuclear dynamics in skeletal muscle across species.
Viggars MR, Owens DJ, Stewart C, Coirault C, Mackey AL, Jarvis JC. Viggars MR, et al. Am J Physiol Cell Physiol. 2023 Jan 1;324(1):C85-C97. doi: 10.1152/ajpcell.00285.2022. Epub 2022 Nov 21. Am J Physiol Cell Physiol. 2023. PMID: 36409178 Free article.
Fibers were immunolabeled for PCM1, Pax7, and DNA. C2C12 myoblasts were also studied to investigate changes in PCM1 localization during myogenesis. ...PCM1 may prove useful as a marker of satellite cell dynamics due to the distinct change in localization duri …
Fibers were immunolabeled for PCM1, Pax7, and DNA. C2C12 myoblasts were also studied to investigate changes in PCM1 localizati …
Updates on eosinophilic disorders.
Tzankov A, Reichard KK, Hasserjian RP, Arber DA, Orazi A, Wang SA. Tzankov A, et al. Virchows Arch. 2023 Jan;482(1):85-97. doi: 10.1007/s00428-022-03402-8. Epub 2022 Sep 7. Virchows Arch. 2023. PMID: 36068374 Review.
Two new members, M/LN-eo with ETV6::ABL1 fusion and M/LN-eo with various FLT3 fusions, have been added to the category; and M/LN-eo with PCM1::JAK2 and its genetic variants ETV6::JAK2 and BCR::JAK2 are recognized as a formal entity from their former provisional status. ...
Two new members, M/LN-eo with ETV6::ABL1 fusion and M/LN-eo with various FLT3 fusions, have been added to the category; and M/LN-eo with …
World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management.
Shomali W, Gotlib J. Shomali W, et al. Am J Hematol. 2022 Jan 1;97(1):129-148. doi: 10.1002/ajh.26352. Epub 2021 Oct 8. Am J Hematol. 2022. PMID: 34533850 Free article.
This includes the major category "myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1 or with PCM1-JAK2", and the myeloproliferative neoplasm subtype, "chronic eosinophilic leukemia, not otherwise specified" (CEL, NOS). ...
This includes the major category "myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1 or with PCM1 …
Myeloid Neoplasm with PCM1-PDGFRB Transcript Responded to Low-Dose Imatinib: One Case Report with Literature Review.
Wang Z, Wan L, Lin D, Li CW, Tian Z, Mi YC. Wang Z, et al. Acta Haematol. 2022;145(5):560-565. doi: 10.1159/000524275. Epub 2022 Mar 25. Acta Haematol. 2022. PMID: 35340014 Free PMC article. Review.
Through an RNA-seq analysis of an adult patient with unclassifiable myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U), we identified a rare PDGFRB fusion partner gene, PCM1. Conventional chromosome karyotype analysis showed abnormal clones of t(5;8)(q32;p22), and fl …
Through an RNA-seq analysis of an adult patient with unclassifiable myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U), we identified …
PCM1-JAK2-fusion: a potential treatment target in myelodysplastic-myeloproliferative and other hemato-lymphoid neoplasms.
Hoeller S, Walz C, Reiter A, Dirnhofer S, Tzankov A. Hoeller S, et al. Expert Opin Ther Targets. 2011 Jan;15(1):53-62. doi: 10.1517/14728222.2011.538683. Epub 2010 Nov 20. Expert Opin Ther Targets. 2011. PMID: 21091042 Review.
WHAT THE READER WILL GAIN: The reader will gain important insights considering PCM1-JAK2 fusion in hematologic malignancies. TAKE HOME MESSAGE: JAK2 is a tyrosine kinase with oncogenic potential in hematologic malignancies. ...
WHAT THE READER WILL GAIN: The reader will gain important insights considering PCM1-JAK2 fusion in hematologic malignancies. TAKE HOM …
The international consensus classification of eosinophilic disorders and systemic mastocytosis.
Wang SA, Orazi A, Gotlib J, Reiter A, Tzankov A, Hasserjian RP, Arber DA, Tefferi A. Wang SA, et al. Am J Hematol. 2023 Aug;98(8):1286-1306. doi: 10.1002/ajh.26966. Epub 2023 Jun 7. Am J Hematol. 2023. PMID: 37283522 Review.
The category has been expanded to include ETV6::ABL1 and FLT3 fusions, and to accept PCM1::JAK2 and its genetic variants as formal members. The overlaps and differences between M/LN-eo-TK and BCR::ABL1-like B-lymphoblastic leukemia (ALL)/de novo T-ALL sharing the same gene …
The category has been expanded to include ETV6::ABL1 and FLT3 fusions, and to accept PCM1::JAK2 and its genetic variants as formal me …
PCM1-JAK2 Fusion Tyrosine Kinase Gene-Related Neoplasia: A Systematic Review of the Clinical Literature.
Kaplan HG, Jin R, Bifulco CB, Scanlan JM, Corwin DR. Kaplan HG, et al. Oncologist. 2022 Aug 5;27(8):e661-e670. doi: 10.1093/oncolo/oyac072. Oncologist. 2022. PMID: 35472244 Free PMC article.
BACKGROUND: This review summarizes the case studies of PCM1-JAK2 fusion tyrosine kinase gene-related neoplasia. Recommended treatment includes JAK2 inhibitors and hematologic stem cell transplantation (HSCT), although the small number of patients has limited study of their …
BACKGROUND: This review summarizes the case studies of PCM1-JAK2 fusion tyrosine kinase gene-related neoplasia. Recommended treatment …
Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes.
Begar E, Seyrek E, Firat-Karalar EN. Begar E, et al. FEBS J. 2024 Jun 2. doi: 10.1111/febs.17194. Online ahead of print. FEBS J. 2024. PMID: 38825736 Review.
These structures remained enigmatic until the identification of pericentriolar material 1 protein (PCM1) as their molecular marker, which has enabled their in-depth characterization. ...We then examine the implications of their dysregulation in various diseases, particular …
These structures remained enigmatic until the identification of pericentriolar material 1 protein (PCM1) as their molecular marker, w …
PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide.
Hoang-Minh LB, Deleyrolle LP, Nakamura NS, Parker AK, Martuscello RT, Reynolds BA, Sarkisian MR. Hoang-Minh LB, et al. Transl Oncol. 2016 Oct;9(5):392-402. doi: 10.1016/j.tranon.2016.08.006. Epub 2016 Sep 20. Transl Oncol. 2016. PMID: 27661404 Free PMC article.
To test whether PCM1 mediates GBM cell proliferation and/or response to TMZ, we used CRISPR/Cas9 genome editing to generate primary GBM cell lines depleted of PCM1. ...Furthermore, PCM1-depleted lines were more sensitive to TMZ toxicity than control lines. .. …
To test whether PCM1 mediates GBM cell proliferation and/or response to TMZ, we used CRISPR/Cas9 genome editing to generate primary G …
322 results