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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 2
1982 5
1983 8
1984 12
1985 17
1986 27
1987 33
1988 47
1989 45
1990 51
1991 52
1992 57
1993 115
1994 123
1995 158
1996 169
1997 132
1998 172
1999 129
2000 172
2001 149
2002 159
2003 179
2004 175
2005 194
2006 177
2007 208
2008 202
2009 227
2010 241
2011 272
2012 263
2013 257
2014 269
2015 279
2016 251
2017 231
2018 223
2019 241
2020 250
2021 209
2022 248
2023 230
2024 111

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6,192 results

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Page 1
Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma.
Abuhamad AY, Mohamad Zamberi NN, Vanharanta S, Mohd Yusuf SNH, Mohtar MA, Syafruddin SE. Abuhamad AY, et al. Int J Mol Sci. 2023 Mar 29;24(7):6447. doi: 10.3390/ijms24076447. Int J Mol Sci. 2023. PMID: 37047421 Free PMC article.
We found that ccRCC cells secreted PDGFB extracellularly, and by utilizing KLF6- and PDGFB-engineered ccRCC cells, we showed that the level of PDGFB secretion was positively correlated with the expression of intracellular KLF6 and PDGFB. ...In conclusi …
We found that ccRCC cells secreted PDGFB extracellularly, and by utilizing KLF6- and PDGFB-engineered ccRCC cells, we showed t …
Intratumoral PDGFB gene predominantly expressed in endothelial cells is associated with angiogenesis and lymphangiogenesis, but not with metastasis in breast cancer.
Wu R, Gandhi S, Tokumaru Y, Asaoka M, Oshi M, Yan L, Ishikawa T, Takabe K. Wu R, et al. Breast Cancer Res Treat. 2022 Aug;195(1):17-31. doi: 10.1007/s10549-022-06661-w. Epub 2022 Jul 6. Breast Cancer Res Treat. 2022. PMID: 35793004
The median value was used to divide each cohort into high and low PDGFB expression groups. RESULTS: High PDGFB gene expression was associated with increased expression of angiogenesis-related genes, higher amount of vascular cell infiltrations, and with enric …
The median value was used to divide each cohort into high and low PDGFB expression groups. RESULTS: High PDGFB gene expression …
Breaking the feed forward inflammatory cytokine loop in the tumor microenvironment of PDGFB-driven glioblastomas.
Miller CR, Hjelmeland AB. Miller CR, et al. J Clin Invest. 2023 Nov 15;133(22):e175127. doi: 10.1172/JCI175127. J Clin Invest. 2023. PMID: 37966120 Free PMC article.
In this issue of the JCI, Chen, Giotti, and colleagues investigated loss of ll1b in the immune tumor microenvironment (TME) in GBM models driven by PDGFB expression and Nf1 knockdown. Survival was only improved in PDGFB-driven GBM models, suggesting that tumor cell …
In this issue of the JCI, Chen, Giotti, and colleagues investigated loss of ll1b in the immune tumor microenvironment (TME) in GBM models dr …
Protein detection using proximity-dependent DNA ligation assays.
Fredriksson S, Gullberg M, Jarvius J, Olsson C, Pietras K, Gústafsdóttir SM, Ostman A, Landegren U. Fredriksson S, et al. Nat Biotechnol. 2002 May;20(5):473-7. doi: 10.1038/nbt0502-473. Nat Biotechnol. 2002. PMID: 11981560
Living with primary brain calcification with PDGFB variants: A qualitative study.
Takeuchi T, Aoyagi H, Kuwako Y, Hozumi I. Takeuchi T, et al. PLoS One. 2022 Oct 7;17(10):e0275227. doi: 10.1371/journal.pone.0275227. eCollection 2022. PLoS One. 2022. PMID: 36206226 Free PMC article.
INTRODUCTION: Primary brain calcification (PBC) is a rare and intractable neurodegenerative disease. SLC20A2 and PDGFB are two major causative genes. As there is no effective treatment to avoid further progression or to prevent the onset of the disease, the patients …
INTRODUCTION: Primary brain calcification (PBC) is a rare and intractable neurodegenerative disease. SLC20A2 and PDGFB are two major …
Bone-derived PDGF-BB drives brain vascular calcification in male mice.
Wang J, Fang CL, Noller K, Wei Z, Liu G, Shen K, Song K, Cao X, Wan M. Wang J, et al. J Clin Invest. 2023 Dec 1;133(23):e168447. doi: 10.1172/JCI168447. J Clin Invest. 2023. PMID: 37815871 Free PMC article.
Conversely, mice with preosteoclast-specific Pdgfb deletion displayed diminished age-associated thalamic calcification. ...Analysis of osteogenic gene array and single-cell RNA-Seq (scRNA-Seq) revealed that PDGF-BB upregulated multiple osteogenic differentiation genes …
Conversely, mice with preosteoclast-specific Pdgfb deletion displayed diminished age-associated thalamic calcification. ...Analysis o …
KLF7 promotes colon adenocarcinoma progression through the PDGFB signaling pathway.
Zhang Z, Jiang X, Li K, Qiao S, Li M, Mei Y, Ding L, Lv Q, Ding Y, Zhao Y, Lv G, Tan G, Yang H, Li G, Gao X, Liu M. Zhang Z, et al. Int J Biol Sci. 2024 Jan 1;20(1):387-402. doi: 10.7150/ijbs.86385. eCollection 2024. Int J Biol Sci. 2024. PMID: 38164176 Free PMC article.
Mechanistically, our findings reveal that KLF7 can specifically bind to the promoter region of PDGFB (TGGGTGGAG), thus promoting the transcription of PDGFB and increasing its secretion. Subsequently, secreted PDGFB facilitates the progression of COAD by activ …
Mechanistically, our findings reveal that KLF7 can specifically bind to the promoter region of PDGFB (TGGGTGGAG), thus promoting the …
Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in TP53, KMT genes and PDGFB fusions.
Das S, Idate R, Lana SE, Regan DP, Duval DL. Das S, et al. Sci Rep. 2023 Jun 27;13(1):10422. doi: 10.1038/s41598-023-37266-y. Sci Rep. 2023. PMID: 37369741 Free PMC article.
The most common driver mutations were in cell cycle/DNA repair (31%, TP53-21%) and chromatin organization/binding (41%, KMT2D-21%) genes. Similar to a subset of human sarcomas, we identified fusion transcripts of platelet derived growth factor B and collagen genes t …
The most common driver mutations were in cell cycle/DNA repair (31%, TP53-21%) and chromatin organization/binding (41%, KMT2D-21%) genes …
SB431542 alleviates lupus nephritis by regulating B cells and inhibiting the TLR9/TGFbeta1/PDGFB signaling.
Xia Y, Jiang C, Yang M, Liu T, Zou X, Li C, Wang X. Xia Y, et al. J Autoimmun. 2022 Oct;132:102894. doi: 10.1016/j.jaut.2022.102894. Epub 2022 Aug 26. J Autoimmun. 2022. PMID: 36030617
A comparative transcriptional profiling analysis revealed 586 differentially expressed genes (247 downregulated genes) in the SB431542 group compared to the control group. ...Kyoto encyclopedia of genes and genomes pathway analysis revealed that the hematopoi …
A comparative transcriptional profiling analysis revealed 586 differentially expressed genes (247 downregulated genes) in the …
A Promising Candidate in Tendon Healing Events-PDGF-BB.
Chen Y, Jiang L, Lyu K, Lu J, Long L, Wang X, Liu T, Li S. Chen Y, et al. Biomolecules. 2022 Oct 20;12(10):1518. doi: 10.3390/biom12101518. Biomolecules. 2022. PMID: 36291727 Free PMC article. Review.
6,192 results