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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
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1999 2
2000 1
2001 3
2004 4
2005 2
2006 2
2007 1
2009 3
2010 3
2011 1
2012 5
2013 3
2014 5
2015 4
2016 2
2017 5
2018 3
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2020 12
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2023 15
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91 results

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Page 1
Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity.
Hadtstein F, Vrolijk M. Hadtstein F, et al. Adv Nutr. 2021 Oct 1;12(5):1911-1929. doi: 10.1093/advances/nmab033. Adv Nutr. 2021. PMID: 33912895 Free PMC article. Review.
Recent reports on hereditary neuropathy due to pyridoxal kinase (PDXK) mutations may provide some insight into the mechanism, as genetic deficiencies in PDXK lead to the development of axonal sensory neuropathy. ...Compounds that inhibit PDXK lead to convulsi …
Recent reports on hereditary neuropathy due to pyridoxal kinase (PDXK) mutations may provide some insight into the mechanism, as gene …
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma.
Chen Y, Tang L, Huang W, Abisola FH, Zhang Y, Zhang G, Yao L. Chen Y, et al. Biol Direct. 2023 Feb 7;18(1):4. doi: 10.1186/s13062-023-00358-w. Biol Direct. 2023. PMID: 36750831 Free PMC article.
The knockdown of PDXK reduced the proliferation, migration and invasion of HCC cells. ...And PDXK deficiency increased the sensitivity of HCC cells to cuproptosis inducer. ...
The knockdown of PDXK reduced the proliferation, migration and invasion of HCC cells. ...And PDXK deficiency increased the sen …
PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation.
Chelban V, Wilson MP, Warman Chardon J, Vandrovcova J, Zanetti MN, Zamba-Papanicolaou E, Efthymiou S, Pope S, Conte MR, Abis G, Liu YT, Tribollet E, Haridy NA, Botía JA, Ryten M, Nicolaou P, Minaidou A, Christodoulou K, Kernohan KD, Eaton A, Osmond M, Ito Y, Bourque P, Jepson JEC, Bello O, Bremner F, Cordivari C, Reilly MM, Foiani M, Heslegrave A, Zetterberg H, Heales SJR, Wood NW, Rothman JE, Boycott KM, Mills PB, Clayton PT, Houlden H; Care4Rare Canada Consortium and the SYNaPS Study Group. Chelban V, et al. Ann Neurol. 2019 Aug;86(2):225-240. doi: 10.1002/ana.25524. Epub 2019 Jul 1. Ann Neurol. 2019. PMID: 31187503 Free PMC article.
We identified conformational rearrangement in the mutant enzyme around the ATP-binding pocket. Low PDXK ATP binding resulted in decreased erythrocyte PDXK activity and low pyridoxal 5'-phosphate (PLP) concentrations. We rescued the clinical and biochemical profile w …
We identified conformational rearrangement in the mutant enzyme around the ATP-binding pocket. Low PDXK ATP binding resulted in decre …
A 20-year Clinical and Genetic Neuromuscular Cohort Analysis in Lebanon: An International Effort.
Megarbane A, Bizzari S, Deepthi A, Sabbagh S, Mansour H, Chouery E, Hmaimess G, Jabbour R, Mehawej C, Alame S, Hani A, Hasbini D, Ghanem I, Koussa S, Al-Ali MT, Obeid M, Talea DB, Lefranc G, Lévy N, Leturcq F, El Hayek S, Delague V, Urtizberea JA. Megarbane A, et al. J Neuromuscul Dis. 2022;9(1):193-210. doi: 10.3233/JND-210652. J Neuromuscul Dis. 2022. PMID: 34602496 Free PMC article.
Hereditary polyneuropathy with optic atrophy due to PDXK variant leading to impaired Vitamin B6 metabolism.
Keller N, Mendoza-Ferreira N, Maroofian R, Chelban V, Khalil Y, Mills PB, Boostani R, Torbati PN, Karimiani EG, Thiele H, Houlden H, Wirth B, Karakaya M. Keller N, et al. Neuromuscul Disord. 2020 Jul;30(7):583-589. doi: 10.1016/j.nmd.2020.04.004. Epub 2020 Apr 29. Neuromuscul Disord. 2020. PMID: 32522499
PDXK encodes for a pyridoxal kinase, which converts inactive B(6) vitamers to the active cofactor pyridoxal 5'-phosphate (PLP). ...We recommend that patients presenting with similar phenotype should be screened for PDXK mutations, as this is a rare opportunity for t …
PDXK encodes for a pyridoxal kinase, which converts inactive B(6) vitamers to the active cofactor pyridoxal 5'-phosphate (PLP). ...We …
A loss of Pdxk model of Parkinson disease in Drosophila can be suppressed by Buffy.
M'Angale PG, Staveley BE. M'Angale PG, et al. BMC Res Notes. 2017 Jun 12;10(1):205. doi: 10.1186/s13104-017-2526-8. BMC Res Notes. 2017. PMID: 28606139 Free PMC article.
The inhibition of Pdxk in the alpha-synuclein-induced Drosophila model of PD did not alter longevity and climbing ability of these flies. ...When Pdxk was inhibited with the alpha-synuclein-induced developmental eye defects, the eye phenotypes were unaltered. ...
The inhibition of Pdxk in the alpha-synuclein-induced Drosophila model of PD did not alter longevity and climbing ability of these fl …
MicroRNA339 Targeting PDXK Improves Motor Dysfunction and Promotes Neurite Growth in the Remote Cortex Subjected to Spinal Cord Transection.
Xiong LL, Qin YX, Xiao QX, Jin Y, Al-Hawwas M, Ma Z, Wang YC, Belegu V, Zhou XF, Xue LL, Du RL, Liu J, Bai X, Wang TH. Xiong LL, et al. Front Cell Dev Biol. 2020 Jul 21;8:577. doi: 10.3389/fcell.2020.00577. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32793586 Free PMC article.
In addition, PDXK was confirmed as a target of miR-339 but not miR-124. MiR-339 knockout (KO) significantly increased the neurite outgrowth and decreased cell apoptosis in cortical neurons. ...The current research therefore confirmed that miR-339 targeting PDXK faci …
In addition, PDXK was confirmed as a target of miR-339 but not miR-124. MiR-339 knockout (KO) significantly increased the neurite out …
[Pyridoxal kinase (PDXK) promotes the proliferation of serous ovarian cancer cells and is associated with poor prognosis].
Tan W, Liu B, Ling H. Tan W, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2020 Jun;36(6):542-548. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2020. PMID: 32696745 Chinese.
PDXK expression was higher in SOC tissues than in normal ovarian tissues. ...Besides, patients with higher PDXK expression had shorter progression-free-survival (PFS). Conclusion PDXK may promote SOC cell proliferation and be associated with a poor prognosis. …
PDXK expression was higher in SOC tissues than in normal ovarian tissues. ...Besides, patients with higher PDXK expression had …
The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity.
Mascolo E, Barile A, Mecarelli LS, Amoroso N, Merigliano C, Massimi A, Saggio I, Hansen T, Tramonti A, Di Salvo ML, Barbetti F, Contestabile R, Vernì F. Mascolo E, et al. Sci Rep. 2019 Oct 2;9(1):14188. doi: 10.1038/s41598-019-50673-4. Sci Rep. 2019. PMID: 31578392 Free PMC article.
Both phenotypes are rescued by the expression of the wild type human PDXK counterpart. Here we expressed, in dPdxk(1) mutant flies, four PDXK human variants: three (D87H, V128I and H246Q) listed in databases, and one (A243G) found in a genetic screening in patients …
Both phenotypes are rescued by the expression of the wild type human PDXK counterpart. Here we expressed, in dPdxk(1) mutant flies, f …
91 results