Pearce KH - Search Results

1

BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 Å resolution.

Pearce KH, Overton LK, Gampe RT, Barrett GB, Taylor JD, McKee DD, Campobasso N, Nolte RT, Reid RA. Pearce KH, et al. Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):239-245. doi: 10.1107/S2053230X19001419. Epub 2019 Mar 13. Acta Crystallogr F Struct Biol Commun. 2019. PMID: 30950824 Free PMC article.

2

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.

Bledsoe RK, Montana VG, Stanley TB, Delves CJ, Apolito CJ, McKee DD, Consler TG, Parks DJ, Stewart EL, Willson TM, Lambert MH, Moore JT, Pearce KH, Xu HE. Bledsoe RK, et al. Among authors: pearce kh. Cell. 2002 Jul 12;110(1):93-105. doi: 10.1016/s0092-8674(02)00817-6. Cell. 2002. PMID: 12151000 Free article.

3

Co-crystal structure guided array synthesis of PPARgamma inverse agonists.

Trump RP, Cobb JE, Shearer BG, Lambert MH, Nolte RT, Willson TM, Buckholz RG, Zhao SM, Leesnitzer LM, Iannone MA, Pearce KH, Billin AN, Hoekstra WJ. Trump RP, et al. Among authors: pearce kh. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3916-20. doi: 10.1016/j.bmcl.2007.04.111. Epub 2007 May 18. Bioorg Med Chem Lett. 2007. PMID: 17533125

4

Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.

Chao EY, Caravella JA, Watson MA, Campobasso N, Ghisletti S, Billin AN, Galardi C, Wang P, Laffitte BA, Iannone MA, Goodwin BJ, Nichols JA, Parks DJ, Stewart E, Wiethe RW, Williams SP, Smallwood A, Pearce KH, Glass CK, Willson TM, Zuercher WJ, Collins JL. Chao EY, et al. Among authors: pearce kh. J Med Chem. 2008 Sep 25;51(18):5758-65. doi: 10.1021/jm800612u. J Med Chem. 2008. PMID: 18800767

5

Recent applications of protein crystallography and structure-guided drug design.

Williams SP, Kuyper LF, Pearce KH. Williams SP, et al. Among authors: pearce kh. Curr Opin Chem Biol. 2005 Aug;9(4):371-80. doi: 10.1016/j.cbpa.2005.06.007. Curr Opin Chem Biol. 2005. PMID: 16006182 Review.

6

Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.

Yin L, Wu N, Curtin JC, Qatanani M, Szwergold NR, Reid RA, Waitt GM, Parks DJ, Pearce KH, Wisely GB, Lazar MA. Yin L, et al. Among authors: pearce kh. Science. 2007 Dec 14;318(5857):1786-9. doi: 10.1126/science.1150179. Epub 2007 Nov 15. Science. 2007. PMID: 18006707

7

High-affinity chromodomains engineered for improved detection of histone methylation and enhanced CRISPR-based gene repression.

Veggiani G, Villaseñor R, Martyn GD, Tang JQ, Krone MW, Gu J, Chen C, Waters ML, Pearce KH, Baubec T, Sidhu SS. Veggiani G, et al. Among authors: pearce kh. Nat Commun. 2022 Nov 15;13(1):6975. doi: 10.1038/s41467-022-34269-7. Nat Commun. 2022. PMID: 36379931 Free PMC article.

8

Structure-Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains.

Stuckey JI, Simpson C, Norris-Drouin JL, Cholensky SH, Lee J, Pasca R, Cheng N, Dickson BM, Pearce KH, Frye SV, James LI. Stuckey JI, et al. Among authors: pearce kh. J Med Chem. 2016 Oct 13;59(19):8913-8923. doi: 10.1021/acs.jmedchem.6b00801. Epub 2016 Sep 19. J Med Chem. 2016. PMID: 27571219 Free PMC article.

9

Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen.

Hull-Ryde EA, Porter MA, Fowler KA, Kireev D, Li K, Simpson CD, Sassano MF, Suto MJ, Pearce KH, Janzen W, Coghill JM. Hull-Ryde EA, et al. Among authors: pearce kh. SLAS Discov. 2018 Dec;23(10):1083-1091. doi: 10.1177/2472555218780917. Epub 2018 Jun 29. SLAS Discov. 2018. PMID: 29958052 Free article.

10

Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.

Gu C, Stashko MA, Puhl-Rubio AC, Chakraborty M, Chakraborty A, Frye SV, Pearce KH, Wang X, Shears SB, Wang H. Gu C, et al. Among authors: pearce kh. J Med Chem. 2019 Feb 14;62(3):1443-1454. doi: 10.1021/acs.jmedchem.8b01593. Epub 2019 Jan 25. J Med Chem. 2019. PMID: 30624931 Free PMC article.

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