Pearl LH - Search Results

1

DNA repair, genome stability and cancer: a historical perspective.

Jeggo PA, Pearl LH, Carr AM. Jeggo PA, et al. Among authors: pearl lh. Nat Rev Cancer. 2016 Jan;16(1):35-42. doi: 10.1038/nrc.2015.4. Epub 2015 Dec 15. Nat Rev Cancer. 2016. PMID: 26667849 Review.

2

An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity.

Woodbine L, Grigoriadou S, Goodarzi AA, Riballo E, Tape C, Oliver AW, van Zelm MC, Buckland MS, Davies EG, Pearl LH, Jeggo PA. Woodbine L, et al. Among authors: pearl lh. DNA Repair (Amst). 2010 Sep 4;9(9):1003-10. doi: 10.1016/j.dnarep.2010.07.001. Epub 2010 Jul 31. DNA Repair (Amst). 2010. PMID: 20674517

3

Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1).

Qu M, Rappas M, Wardlaw CP, Garcia V, Ren JY, Day M, Carr AM, Oliver AW, Du LL, Pearl LH. Qu M, et al. Among authors: pearl lh. Mol Cell. 2013 Sep 26;51(6):723-736. doi: 10.1016/j.molcel.2013.08.030. Mol Cell. 2013. PMID: 24074952 Free PMC article.

4

Therapeutic opportunities within the DNA damage response.

Pearl LH, Schierz AC, Ward SE, Al-Lazikani B, Pearl FM. Pearl LH, et al. Among authors: pearl fm. Nat Rev Cancer. 2015 Mar;15(3):166-80. doi: 10.1038/nrc3891. Nat Rev Cancer. 2015. PMID: 25709118 Free article. Review.

5

Specialized interfaces of Smc5/6 control hinge stability and DNA association.

Alt A, Dang HQ, Wells OS, Polo LM, Smith MA, McGregor GA, Welte T, Lehmann AR, Pearl LH, Murray JM, Oliver AW. Alt A, et al. Among authors: pearl lh. Nat Commun. 2017 Jan 30;8:14011. doi: 10.1038/ncomms14011. Nat Commun. 2017. PMID: 28134253 Free PMC article.

6

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.

Leimbacher PA, Jones SE, Shorrocks AK, de Marco Zompit M, Day M, Blaauwendraad J, Bundschuh D, Bonham S, Fischer R, Fink D, Kessler BM, Oliver AW, Pearl LH, Blackford AN, Stucki M. Leimbacher PA, et al. Among authors: pearl lh. Mol Cell. 2019 May 2;74(3):571-583.e8. doi: 10.1016/j.molcel.2019.02.014. Epub 2019 Mar 18. Mol Cell. 2019. PMID: 30898438 Free PMC article.

7

Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1.

Day M, Oliver AW, Pearl LH. Day M, et al. Among authors: pearl lh. DNA Repair (Amst). 2021 Dec;108:103232. doi: 10.1016/j.dnarep.2021.103232. Epub 2021 Sep 29. DNA Repair (Amst). 2021. PMID: 34678589 Free PMC article. Review.

8

The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.

Garces F, Pearl LH, Oliver AW. Garces F, et al. Among authors: pearl lh. Mol Cell. 2011 Nov 4;44(3):385-96. doi: 10.1016/j.molcel.2011.08.036. Mol Cell. 2011. PMID: 22055185 Free PMC article.

9

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX.

Baldock RA, Day M, Wilkinson OJ, Cloney R, Jeggo PA, Oliver AW, Watts FZ, Pearl LH. Baldock RA, et al. Among authors: pearl lh. Cell Rep. 2015 Dec 15;13(10):2081-9. doi: 10.1016/j.celrep.2015.10.074. Epub 2015 Nov 25. Cell Rep. 2015. PMID: 26628370 Free PMC article.

10

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.

Grundy GJ, Rulten SL, Arribas-Bosacoma R, Davidson K, Kozik Z, Oliver AW, Pearl LH, Caldecott KW. Grundy GJ, et al. Among authors: pearl lh. Nat Commun. 2016 Apr 11;7:11242. doi: 10.1038/ncomms11242. Nat Commun. 2016. PMID: 27063109 Free PMC article.

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