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Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis.
Pencreach E, Guérin E, Nicolet C, Lelong-Rebel I, Voegeli AC, Oudet P, Larsen AK, Gaub MP, Guenot D. Pencreach E, et al. Clin Cancer Res. 2009 Feb 15;15(4):1297-307. doi: 10.1158/1078-0432.CCR-08-0889. Epub 2009 Feb 3. Clin Cancer Res. 2009. PMID: 19190131
In vivo topoisomerase I inhibition attenuates the expression of hypoxia-inducible factor 1α target genes and decreases tumor angiogenesis.
Guérin E, Raffelsberger W, Pencreach E, Maier A, Neuville A, Schneider A, Bachellier P, Rohr S, Petitprez A, Poch O, Moras D, Oudet P, Larsen AK, Gaub MP, Guenot D. Guérin E, et al. Among authors: pencreach e. Mol Med. 2012 Feb 10;18(1):83-94. doi: 10.2119/molmed.2011.00120. Mol Med. 2012. PMID: 22033674 Free PMC article.
Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value.
Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, Kirzin S, Chazal M, Fléjou JF, Benchimol D, Berger A, Lagarde A, Pencreach E, Piard F, Elias D, Parc Y, Olschwang S, Milano G, Laurent-Puig P, Boige V. Marisa L, et al. Among authors: pencreach e. PLoS Med. 2013;10(5):e1001453. doi: 10.1371/journal.pmed.1001453. Epub 2013 May 21. PLoS Med. 2013. PMID: 23700391 Free PMC article.
36 results