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The central melanocortin system directly controls peripheral lipid metabolism.
Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH. Nogueiras R, et al. J Clin Invest. 2007 Nov;117(11):3475-88. doi: 10.1172/JCI31743. J Clin Invest. 2007. PMID: 17885689 Free PMC article.
Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability.
Nogueiras R, López M, Lage R, Perez-Tilve D, Pfluger P, Mendieta-Zerón H, Sakkou M, Wiedmer P, Benoit SC, Datta R, Dong JZ, Culler M, Sleeman M, Vidal-Puig A, Horvath T, Treier M, Diéguez C, Tschöp MH. Nogueiras R, et al. Endocrinology. 2008 Jun;149(6):3009-15. doi: 10.1210/en.2007-1684. Epub 2008 Feb 28. Endocrinology. 2008. PMID: 18308842 Free PMC article.
Glucagon regulation of energy metabolism.
Heppner KM, Habegger KM, Day J, Pfluger PT, Perez-Tilve D, Ward B, Gelfanov V, Woods SC, DiMarchi R, Tschöp M. Heppner KM, et al. Physiol Behav. 2010 Jul 14;100(5):545-8. doi: 10.1016/j.physbeh.2010.03.019. Epub 2010 Apr 8. Physiol Behav. 2010. PMID: 20381509 Review.
Melanocortin signaling in the CNS directly regulates circulating cholesterol.
Perez-Tilve D, Hofmann SM, Basford J, Nogueiras R, Pfluger PT, Patterson JT, Grant E, Wilson-Perez HE, Granholm NA, Arnold M, Trevaskis JL, Butler AA, Davidson WS, Woods SC, Benoit SC, Sleeman MW, DiMarchi RD, Hui DY, Tschöp MH. Perez-Tilve D, et al. Nat Neurosci. 2010 Jul;13(7):877-82. doi: 10.1038/nn.2569. Epub 2010 Jun 6. Nat Neurosci. 2010. PMID: 20526334 Free PMC article.
114 results