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Year Number of Results
1992 1
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1997 1
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1999 5
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2001 4
2002 11
2003 11
2004 11
2005 31
2006 23
2007 17
2008 25
2009 24
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2012 36
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607 results

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Page 1
Perilipin-2 limits remyelination by preventing lipid droplet degradation.
Loix M, Wouters E, Vanherle S, Dehairs J, McManaman JL, Kemps H, Swinnen JV, Haidar M, Bogie JFJ, Hendriks JJA. Loix M, et al. Cell Mol Life Sci. 2022 Sep 13;79(10):515. doi: 10.1007/s00018-022-04547-0. Cell Mol Life Sci. 2022. PMID: 36100764
To date, however, the mechanisms underlying LD biogenesis and breakdown in lipid-engorged phagocytes in the CNS, as well as their impact on foamy phagocyte biology and lesion progression, remain poorly understood. Here, we provide evidence that LD-associated protein perilipin …
To date, however, the mechanisms underlying LD biogenesis and breakdown in lipid-engorged phagocytes in the CNS, as well as their impact on …
Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.
Roberts MA, Deol KK, Mathiowetz AJ, Lange M, Leto DE, Stevenson J, Hashemi SH, Morgens DW, Easter E, Heydari K, Nalls MA, Bassik MC, Kampmann M, Kopito RR, Faghri F, Olzmann JA. Roberts MA, et al. Dev Cell. 2023 Sep 25;58(18):1782-1800.e10. doi: 10.1016/j.devcel.2023.07.001. Epub 2023 Jul 25. Dev Cell. 2023. PMID: 37494933 Free article.
Despite the key roles of perilipin-2 (PLIN2) in governing lipid droplet (LD) metabolism, the mechanisms that regulate PLIN2 levels remain incompletely understood. Here, we leverage a set of genome-edited human PLIN2 reporter cell lines in a series of C …
Despite the key roles of perilipin-2 (PLIN2) in governing lipid droplet (LD) metabolism, the mechanisms that regulate PLIN2 …
Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation.
Wu Y, Chen K, Li L, Hao Z, Wang T, Liu Y, Xing G, Liu Z, Li H, Yuan H, Lu J, Zhang C, Zhang J, Zhao D, Wang J, Nie J, Ye D, Pan G, Chan WY, Liu X. Wu Y, et al. Cell Death Differ. 2022 Nov;29(11):2316-2331. doi: 10.1038/s41418-022-01018-8. Epub 2022 May 25. Cell Death Differ. 2022. PMID: 35614132 Free PMC article.
Upon exit from pluripotency, lipid droplet (LD)-associated protein Plin2 is recognized by Hsc70 and degraded via chaperone-mediated autophagy to facilitate LD mobilization. Enhancing lipid hydrolysis by Plin2 knockout promotes pluripotency exit, which is recovered b …
Upon exit from pluripotency, lipid droplet (LD)-associated protein Plin2 is recognized by Hsc70 and degraded via chaperone-mediated a …
The constitutive lipid droplet protein PLIN2 regulates autophagy in liver.
Tsai TH, Chen E, Li L, Saha P, Lee HJ, Huang LS, Shelness GS, Chan L, Chang BH. Tsai TH, et al. Autophagy. 2017 Jul 3;13(7):1130-1144. doi: 10.1080/15548627.2017.1319544. Epub 2017 May 26. Autophagy. 2017. PMID: 28548876 Free PMC article.
Lipid droplets are home to the lipid droplet proteins, the most abundant of which are the perilipins (PLINs), encoded by 5 different genes, Plin1 to Plin5. Of the corresponding gene products, PLIN2 is the only constitutive and ubiquitously expressed lipid droplet pr …
Lipid droplets are home to the lipid droplet proteins, the most abundant of which are the perilipins (PLINs), encoded by 5 different …
AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA.
Kaushik S, Cuervo AM. Kaushik S, et al. Autophagy. 2016;12(2):432-8. doi: 10.1080/15548627.2015.1124226. Autophagy. 2016. PMID: 26902588 Free PMC article.
PLIN2 phosphorylation was observed upon induction of lipolysis, but the phosphorylating kinase and the relation of this phosphorylation with CMA of PLIN2 remained unknown. Here, we report that phosphorylation of PLIN2 is dependent on AMPK and occurs after the …
PLIN2 phosphorylation was observed upon induction of lipolysis, but the phosphorylating kinase and the relation of this phosphorylati …
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis.
Kaushik S, Cuervo AM. Kaushik S, et al. Nat Cell Biol. 2015 Jun;17(6):759-70. doi: 10.1038/ncb3166. Epub 2015 May 11. Nat Cell Biol. 2015. PMID: 25961502 Free PMC article.
A potent physiological activator of CMA is nutrient deprivation, a condition in which intracellular triglyceride stores or lipid droplets (LDs) also undergo hydrolysis (lipolysis) to generate free fatty acids for energetic purposes. Here we report that the LD-associated proteins …
A potent physiological activator of CMA is nutrient deprivation, a condition in which intracellular triglyceride stores or lipid droplets (L …
Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice.
Doncheva AI, Li Y, Khanal P, Hjorth M, Kolset SO, Norheim FA, Kimmel AR, Dalen KT. Doncheva AI, et al. J Lipid Res. 2023 Dec;64(12):100461. doi: 10.1016/j.jlr.2023.100461. Epub 2023 Oct 14. J Lipid Res. 2023. PMID: 37844775 Free PMC article.
Perilipin 2 (Plin2) binds to the surface of hepatic lipid droplets (LDs) with expression levels that correlate with triacylglyceride (TAG) content. We investigated if Plin2 is important for hepatic LD storage in fasted or high-fat diet-induced obese Plin2 …
Perilipin 2 (Plin2) binds to the surface of hepatic lipid droplets (LDs) with expression levels that correlate with triacylgly …
PLIN2 promotes HCC cells proliferation by inhibiting the degradation of HIF1alpha.
Liu W, Liu X, Liu Y, Ling T, Chen D, Otkur W, Zhao H, Ma M, Ma K, Dong B, Yang Z, Piao HL, Liang R, Dong C. Liu W, et al. Exp Cell Res. 2022 Sep 1;418(1):113244. doi: 10.1016/j.yexcr.2022.113244. Epub 2022 Jun 10. Exp Cell Res. 2022. PMID: 35697078
Here, we revealed that PLIN2 was frequently upregulated in HCC cells and tissues, and increased PLIN2 expression was associated with poor prognosis outcomes in HCC. In HCC cells, overexpressing PLIN2 promoted cell proliferation, PLIN2-deficiency inhibi …
Here, we revealed that PLIN2 was frequently upregulated in HCC cells and tissues, and increased PLIN2 expression was associate …
Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective.
Conte M, Franceschi C, Sandri M, Salvioli S. Conte M, et al. Trends Endocrinol Metab. 2016 Dec;27(12):893-903. doi: 10.1016/j.tem.2016.09.001. Epub 2016 Sep 19. Trends Endocrinol Metab. 2016. PMID: 27659144 Review.
Perilipin 2 (Plin2), a protein associated with the metabolism of intracellular lipid droplets (LDs), has long been considered only for its role in lipid storage. ...We propose that inhibition of Plin2 might be a strategy to counteract several metabolic and ag …
Perilipin 2 (Plin2), a protein associated with the metabolism of intracellular lipid droplets (LDs), has long been considered …
Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages.
Son SH, Goo YH, Chang BH, Paul A. Son SH, et al. PLoS One. 2012;7(3):e33063. doi: 10.1371/journal.pone.0033063. Epub 2012 Mar 12. PLoS One. 2012. PMID: 22427949 Free PMC article.
Like in other cell types, PLIN2 deficiency impairs LD buildup in BMM. However, while most stress parameters were elevated in macrophages under ACAT inhibition and 7-KC loading, PLIN2 inactivation was well tolerated. The data support the safety of targeting PLIN2 …
Like in other cell types, PLIN2 deficiency impairs LD buildup in BMM. However, while most stress parameters were elevated in macropha …
607 results