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Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.
Wan ZK, Chenail E, Li HQ, Ipek M, Xiang J, Suri V, Hahm S, Bard J, Svenson K, Xu X, Tian X, Wang M, Li X, Johnson CE, Qadri A, Panza D, Perreault M, Mansour TS, Tobin JF, Saiah E. Wan ZK, et al. Among authors: perreault m. ACS Med Chem Lett. 2012 Nov 23;4(1):118-23. doi: 10.1021/ml300352x. eCollection 2013 Jan 10. ACS Med Chem Lett. 2012. PMID: 24900572 Free PMC article.
Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases.
Cao J, Zhou Y, Peng H, Huang X, Stahler S, Suri V, Qadri A, Gareski T, Jones J, Hahm S, Perreault M, McKew J, Shi M, Xu X, Tobin JF, Gimeno RE. Cao J, et al. Among authors: perreault m. J Biol Chem. 2011 Dec 2;286(48):41838-41851. doi: 10.1074/jbc.M111.245456. Epub 2011 Oct 11. J Biol Chem. 2011. PMID: 21990351 Free PMC article.
Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity.
Cao J, Perez S, Goodwin B, Lin Q, Peng H, Qadri A, Zhou Y, Clark RW, Perreault M, Tobin JF, Gimeno RE. Cao J, et al. Among authors: perreault m. Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1176-87. doi: 10.1152/ajpendo.00666.2013. Epub 2014 Apr 8. Am J Physiol Endocrinol Metab. 2014. PMID: 24714397 Free article.
Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent.
Artis DR, Lin JJ, Zhang C, Wang W, Mehra U, Perreault M, Erbe D, Krupka HI, England BP, Arnold J, Plotnikov AN, Marimuthu A, Nguyen H, Will S, Signaevsky M, Kral J, Cantwell J, Settachatgull C, Yan DS, Fong D, Oh A, Shi S, Womack P, Powell B, Habets G, West BL, Zhang KY, Milburn MV, Vlasuk GP, Hirth KP, Nolop K, Bollag G, Ibrahim PN, Tobin JF. Artis DR, et al. Among authors: perreault m. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):262-7. doi: 10.1073/pnas.0811325106. Epub 2008 Dec 30. Proc Natl Acad Sci U S A. 2009. PMID: 19116277 Free PMC article.
359 results