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320 results

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Page 1
Personalized medicine: motivation, challenges, and progress.
Goetz LH, Schork NJ. Goetz LH, et al. Fertil Steril. 2018 Jun;109(6):952-963. doi: 10.1016/j.fertnstert.2018.05.006. Fertil Steril. 2018. PMID: 29935653 Free PMC article. Review.
In this review, we consider the motivation for personalized medicine, its historical precedents, the emerging technologies that are enabling it, some recent experiences including successes and setbacks, ways of vetting and deploying personalized medicines, an …
In this review, we consider the motivation for personalized medicine, its historical precedents, the emerging technologies tha …
Pharmacogenomics: Driving Personalized Medicine.
Sadee W, Wang D, Hartmann K, Toland AE. Sadee W, et al. Pharmacol Rev. 2023 Jul;75(4):789-814. doi: 10.1124/pharmrev.122.000810. Epub 2023 Mar 16. Pharmacol Rev. 2023. PMID: 36927888 Free PMC article. Review.
Personalized medicine tailors therapies, disease prevention, and health maintenance to the individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent adverse effects. ...This review address the underlying science and technologies germane …
Personalized medicine tailors therapies, disease prevention, and health maintenance to the individual, with pharmacogenomics s …
Clinical application of advanced multi-omics tumor profiling: Shaping precision oncology of the future.
Akhoundova D, Rubin MA. Akhoundova D, et al. Cancer Cell. 2022 Sep 12;40(9):920-938. doi: 10.1016/j.ccell.2022.08.011. Epub 2022 Sep 1. Cancer Cell. 2022. PMID: 36055231 Free article. Review.
Clinical translation of high-resolution tumor profiling and integration of multi-omics data into precision treatment, however, pose significant challenges at the level of prospective validation and clinical implementation. In this review, we summarize the latest advances i …
Clinical translation of high-resolution tumor profiling and integration of multi-omics data into precision treatment, however, pose s …
Precision Medicine in Depression: The Role of Proteomics and Metabolomics in Personalized Treatment Approaches.
Jaber M, Kahwaji H, Nasr S, Baz R, Kim YK, Fakhoury M. Jaber M, et al. Adv Exp Med Biol. 2024;1456:359-378. doi: 10.1007/978-981-97-4402-2_18. Adv Exp Med Biol. 2024. PMID: 39261438 Review.
In particular, precision medicine has offered novel viewpoints on depression through two specific domains: proteomics and metabolomics. ...However, despite significant progress in these techniques, further efforts are required for advancing precision …
In particular, precision medicine has offered novel viewpoints on depression through two specific domains: proteomics a …
Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments.
Lone SN, Nisar S, Masoodi T, Singh M, Rizwan A, Hashem S, El-Rifai W, Bedognetti D, Batra SK, Haris M, Bhat AA, Macha MA. Lone SN, et al. Mol Cancer. 2022 Mar 18;21(1):79. doi: 10.1186/s12943-022-01543-7. Mol Cancer. 2022. PMID: 35303879 Free PMC article. Review.
Liquid biopsies have drastically revolutionized the field of clinical oncology, offering ease in tumor sampling, continuous monitoring by repeated sampling, devising personalized therapeutic regimens, and screening for therapeutic resistance. Liquid biopsies consist of iso …
Liquid biopsies have drastically revolutionized the field of clinical oncology, offering ease in tumor sampling, continuous monitoring by re …
Unveiling the future of metabolic medicine: omics technologies driving personalized solutions for precision treatment of metabolic disorders.
Singh S, Sarma DK, Verma V, Nagpal R, Kumar M. Singh S, et al. Biochem Biophys Res Commun. 2023 Nov 19;682:1-20. doi: 10.1016/j.bbrc.2023.09.064. Epub 2023 Sep 29. Biochem Biophys Res Commun. 2023. PMID: 37788525 Review.
The variety of metabolic illnesses can be addressed through personalized medicine. The goal of personalized medicine is to give doctors the ability to anticipate the best course of treatment for patients with metabolic problems. ...It focuses on the re …
The variety of metabolic illnesses can be addressed through personalized medicine. The goal of personalized medicine …
Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities.
Jiang YZ, Ma D, Jin X, Xiao Y, Yu Y, Shi J, Zhou YF, Fu T, Lin CJ, Dai LJ, Liu CL, Zhao S, Su GH, Hou W, Liu Y, Chen Q, Yang J, Zhang N, Zhang WJ, Liu W, Ge W, Yang WT, You C, Gu Y, Kaklamani V, Bertucci F, Verschraegen C, Daemen A, Shah NM, Wang T, Guo T, Shi L, Perou CM, Zheng Y, Huang W, Shao ZM. Jiang YZ, et al. Nat Cancer. 2024 Apr;5(4):673-690. doi: 10.1038/s43018-024-00725-0. Epub 2024 Feb 12. Nat Cancer. 2024. PMID: 38347143
Molecular profiling guides precision treatment of breast cancer; however, Asian patients are underrepresented in publicly available large-scale studies. ...Furthermore, comprehensive metabolomic and proteomic analyses revealed ferroptosis as a potential therapeutic …
Molecular profiling guides precision treatment of breast cancer; however, Asian patients are underrepresented in publicly available l …
Present and future directions in diabetic kidney disease.
Limonte CP, Kretzler M, Pennathur S, Pop-Busui R, de Boer IH. Limonte CP, et al. J Diabetes Complications. 2022 Dec;36(12):108357. doi: 10.1016/j.jdiacomp.2022.108357. Epub 2022 Nov 14. J Diabetes Complications. 2022. PMID: 36403478 Free PMC article. Review.
Novel applications of transcriptomic, proteomic, and metabolomic/lipidomic technologies, as well as use of artificial intelligence and reinforced learning methods through consortia such as the Kidney Precision Medicine Project and focused studies in establish …
Novel applications of transcriptomic, proteomic, and metabolomic/lipidomic technologies, as well as use of artificial intelligence an …
An atlas of genetic scores to predict multi-omic traits.
Xu Y, Ritchie SC, Liang Y, Timmers PRHJ, Pietzner M, Lannelongue L, Lambert SA, Tahir UA, May-Wilson S, Foguet C, Johansson Å, Surendran P, Nath AP, Persyn E, Peters JE, Oliver-Williams C, Deng S, Prins B, Luan J, Bomba L, Soranzo N, Di Angelantonio E, Pirastu N, Tai ES, van Dam RM, Parkinson H, Davenport EE, Paul DS, Yau C, Gerszten RE, Mälarstig A, Danesh J, Sim X, Langenberg C, Wilson JF, Butterworth AS, Inouye M. Xu Y, et al. Nature. 2023 Apr;616(7955):123-131. doi: 10.1038/s41586-023-05844-9. Epub 2023 Mar 29. Nature. 2023. PMID: 36991119 Free PMC article.
Here we examine a large cohort (the INTERVAL study(2); n = 50,000 participants) with extensive multi-omic data for plasma proteomics (SomaScan, n = 3,175; Olink, n = 4,822), plasma metabolomics (Metabolon HD4, n = 8,153), serum metabolomics (Nightingale, n = 37,359) and wh …
Here we examine a large cohort (the INTERVAL study(2); n = 50,000 participants) with extensive multi-omic data for plasma proteomics …
Noninvasive Prenatal Testing Using Circulating DNA and RNA: Advances, Challenges, and Possibilities.
Moufarrej MN, Bianchi DW, Shaw GM, Stevenson DK, Quake SR. Moufarrej MN, et al. Annu Rev Biomed Data Sci. 2023 Aug 10;6:397-418. doi: 10.1146/annurev-biodatasci-020722-094144. Epub 2023 May 17. Annu Rev Biomed Data Sci. 2023. PMID: 37196360 Free PMC article. Review.
Advances in noninvasive prenatal testing expand the scope of precision medicine in obstetric care. In this review, we discuss advances, challenges, and possibilities toward the goal of providing proactive, personalized prenatal care. ...Finally, we look to …
Advances in noninvasive prenatal testing expand the scope of precision medicine in obstetric care. In this review, we discuss …
320 results