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Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Sveidahl Johansen O, Ma T, Hansen JB, Markussen LK, Schreiber R, Reverte-Salisa L, Dong H, Christensen DP, Sun W, Gnad T, Karavaeva I, Nielsen TS, Kooijman S, Cero C, Dmytriyeva O, Shen Y, Razzoli M, O'Brien SL, Kuipers EN, Nielsen CH, Orchard W, Willemsen N, Jespersen NZ, Lundh M, Sustarsic EG, Hallgren CM, Frost M, McGonigle S, Isidor MS, Broholm C, Pedersen O, Hansen JB, Grarup N, Hansen T, Kjær A, Granneman JG, Babu MM, Calebiro D, Nielsen S, Rydén M, Soccio R, Rensen PCN, Treebak JT, Schwartz TW, Emanuelli B, Bartolomucci A, Pfeifer A, Zechner R, Scheele C, Mandrup S, Gerhart-Hines Z. Sveidahl Johansen O, et al. Among authors: pfeifer a. Cell. 2021 Jun 24;184(13):3502-3518.e33. doi: 10.1016/j.cell.2021.04.037. Epub 2021 May 27. Cell. 2021. PMID: 34048700 Free PMC article.
Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors.
Gnad T, Scheibler S, von Kügelgen I, Scheele C, Kilić A, Glöde A, Hoffmann LS, Reverte-Salisa L, Horn P, Mutlu S, El-Tayeb A, Kranz M, Deuther-Conrad W, Brust P, Lidell ME, Betz MJ, Enerbäck S, Schrader J, Yegutkin GG, Müller CE, Pfeifer A. Gnad T, et al. Among authors: pfeifer a. Nature. 2014 Dec 18;516(7531):395-9. doi: 10.1038/nature13816. Epub 2014 Oct 15. Nature. 2014. PMID: 25317558
The Gq signalling pathway inhibits brown and beige adipose tissue.
Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A. Klepac K, et al. Among authors: pfeifer a. Nat Commun. 2016 Mar 9;7:10895. doi: 10.1038/ncomms10895. Nat Commun. 2016. PMID: 26955961 Free PMC article.
Role of cAMP and cGMP Signaling in Brown Fat.
Reverte-Salisa L, Sanyal A, Pfeifer A. Reverte-Salisa L, et al. Among authors: pfeifer a. Handb Exp Pharmacol. 2019;251:161-182. doi: 10.1007/164_2018_117. Handb Exp Pharmacol. 2019. PMID: 29633180
Cannabinoid Type 1 Receptors Are Upregulated During Acute Activation of Brown Adipose Tissue.
Lahesmaa M, Eriksson O, Gnad T, Oikonen V, Bucci M, Hirvonen J, Koskensalo K, Teuho J, Niemi T, Taittonen M, Lahdenpohja S, U Din M, Haaparanta-Solin M, Pfeifer A, Virtanen KA, Nuutila P. Lahesmaa M, et al. Among authors: pfeifer a. Diabetes. 2018 Jul;67(7):1226-1236. doi: 10.2337/db17-1366. Epub 2018 Apr 12. Diabetes. 2018. PMID: 29650773 Free article. Clinical Trial.
A2A R-induced transcriptional deregulation in astrocytes: An in vitro study.
Paiva I, Carvalho K, Santos P, Cellai L, Pavlou MAS, Jain G, Gnad T, Pfeifer A, Vieau D, Fischer A, Buée L, Outeiro TF, Blum D. Paiva I, et al. Among authors: pfeifer a. Glia. 2019 Dec;67(12):2329-2342. doi: 10.1002/glia.23688. Epub 2019 Jul 22. Glia. 2019. PMID: 31328322
Lack of Gαi2 proteins in adipocytes attenuates diet-induced obesity.
Leiss V, Schönsiegel A, Gnad T, Kerner J, Kaur J, Sartorius T, Machann J, Schick F, Birnbaumer L, Häring HU, Pfeifer A, Nürnberg B. Leiss V, et al. Among authors: pfeifer a. Mol Metab. 2020 Oct;40:101029. doi: 10.1016/j.molmet.2020.101029. Epub 2020 May 30. Mol Metab. 2020. PMID: 32480042 Free PMC article.
425 results