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An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.
Glidden MD, Aldabbagh K, Phillips NB, Carr K, Chen YS, Whittaker J, Phillips M, Wickramasinghe NP, Rege N, Swain M, Peng Y, Yang Y, Lawrence MC, Yee VC, Ismail-Beigi F, Weiss MA. Glidden MD, et al. Among authors: phillips nb. J Biol Chem. 2018 Jan 5;293(1):47-68. doi: 10.1074/jbc.M117.808626. Epub 2017 Nov 7. J Biol Chem. 2018. PMID: 29114035 Free PMC article.
Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.
Pandyarajan V, Smith BJ, Phillips NB, Whittaker L, Cox GP, Wickramasinghe N, Menting JG, Wan ZL, Whittaker J, Ismail-Beigi F, Lawrence MC, Weiss MA. Pandyarajan V, et al. Among authors: phillips nb. J Biol Chem. 2014 Dec 12;289(50):34709-27. doi: 10.1074/jbc.M114.608562. Epub 2014 Oct 10. J Biol Chem. 2014. PMID: 25305014 Free PMC article.
The hidden thermodynamics of a zinc finger.
Lachenmann MJ, Ladbury JE, Phillips NB, Narayana N, Qian X, Weiss MA. Lachenmann MJ, et al. Among authors: phillips nb. J Mol Biol. 2002 Mar 1;316(4):969-89. doi: 10.1006/jmbi.2001.5335. J Mol Biol. 2002. PMID: 11884136
45 results