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Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions.
Curtis DJ, Sood A, Phillips TJ, Leinster VH, Nishiguchi A, Coyle C, Lacharme-Lora L, Beaumont O, Kemp H, Goodall R, Cornes L, Giugliano M, Barone RA, Matsusaki M, Akashi M, Tanaka HY, Kano M, McGarvey J, Halemani ND, Simon K, Keehan R, Ind W, Masters T, Grant S, Athwal S, Collett G, Tannetta D, Sargent IL, Scull-Brown E, Liu X, Aquilina K, Cohen N, Lane JD, Thoresen M, Hanley J, Randall A, Case CP. Curtis DJ, et al. Among authors: phillips tj. Exp Neurol. 2014 Nov;261:386-95. doi: 10.1016/j.expneurol.2014.05.003. Epub 2014 May 10. Exp Neurol. 2014. PMID: 24818543
Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.
Phillips TJ, Scott H, Menassa DA, Bignell AL, Sood A, Morton JS, Akagi T, Azuma K, Rogers MF, Gilmore CE, Inman GJ, Grant S, Chung Y, Aljunaidy MM, Cooke CL, Steinkraus BR, Pocklington A, Logan A, Collett GP, Kemp H, Holmans PA, Murphy MP, Fulga TA, Coney AM, Akashi M, Davidge ST, Case CP. Phillips TJ, et al. Sci Rep. 2017 Aug 22;7(1):9079. doi: 10.1038/s41598-017-06300-1. Sci Rep. 2017. PMID: 28831049 Free PMC article.
Placenta-targeted treatment with nMitoQ prevents an endothelin receptor-A pathway cardiac phenotype observed in adult male offspring exposed to hypoxia in utero.
Hula N, Kirschenman R, Quon A, Spaans F, Phillips TJ, Case CP, Cooke CM, Davidge ST. Hula N, et al. Among authors: phillips tj. Am J Physiol Heart Circ Physiol. 2023 Jul 1;325(1):H136-H141. doi: 10.1152/ajpheart.00238.2023. Epub 2023 May 26. Am J Physiol Heart Circ Physiol. 2023. PMID: 37235521
725 results