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1864 1
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1962 1
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1968 1
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2002 1
2004 1
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Biologically active components of Physostigma venenosum.
Zhao B, Moochhala SM, Tham SY. Zhao B, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 5;812(1-2):183-92. doi: 10.1016/j.jchromb.2004.08.031. J Chromatogr B Analyt Technol Biomed Life Sci. 2004. PMID: 15556497 Review.
Physostigmine is a major alkaloid found in the seeds of the fabaceous plant Physostigma venenosum. It is a powerful and reversible acetylcholine esterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmissio …
Physostigmine is a major alkaloid found in the seeds of the fabaceous plant Physostigma venenosum. It is a powerful and revers …
The Calabar Bean: Physostigma Venenosum.
[No authors listed] [No authors listed] Chic Med J. 1864 Oct;21(10):463-466. Chic Med J. 1864. PMID: 37411960 Free PMC article. No abstract available.
Ethnobotanical treatment strategies against Alzheimer's disease.
Howes MJ, Houghton PJ. Howes MJ, et al. Curr Alzheimer Res. 2012 Jan;9(1):67-85. doi: 10.2174/156720512799015046. Curr Alzheimer Res. 2012. PMID: 22329652 Review.
Plants have been a valuable source of drugs, and phytochemicals have also provided templates to develop synthetic drugs (e.g. rivastigmine, based on the chemical structure of physostigmine from Physostigma venenosum). Although drug development from botanical origin …
Plants have been a valuable source of drugs, and phytochemicals have also provided templates to develop synthetic drugs (e.g. rivastigmine, …
Nature as a source of drugs for ophthalmology.
Pinheiro GKLO, Araújo Filho I, Araújo Neto I, Rêgo ACM, Azevedo EP, Pinheiro FI, Lima Filho AAS. Pinheiro GKLO, et al. Arq Bras Oftalmol. 2018 Sep-Oct;81(5):443-454. doi: 10.5935/0004-2749.20180086. Arq Bras Oftalmol. 2018. PMID: 30208150 Free article. Review.
The search for a drug that effectively lowers intraocular pressure and controls the progression of glaucoma has led to the development of various ocular hypotensive agents, such as physostigmine from the Physostigma venenosum plant. The anesthetic properties of coca …
The search for a drug that effectively lowers intraocular pressure and controls the progression of glaucoma has led to the development of va …
What kind of poison was used in "The Name of the Rose"?
Konopka T. Konopka T. Arch Med Sadowej Kryminol. 2020;70(4):191-201. doi: 10.5114/amsik.2020.104944. Arch Med Sadowej Kryminol. 2020. PMID: 34431644 Free article. Review. English.
Morphine found in opium poppy (Papaver somniferum) and colchicine contained in autumn crocus (Colchicum autumnale) produce lethal effects at similar doses. So do more exotic plants such as Calabar bean (Physostigma venenosum) which contains physostygmine. Two other …
Morphine found in opium poppy (Papaver somniferum) and colchicine contained in autumn crocus (Colchicum autumnale) produce lethal effects at …
The role of phytochemicals in the treatment and prevention of dementia.
Howes MJ, Perry E. Howes MJ, et al. Drugs Aging. 2011 Jun 1;28(6):439-68. doi: 10.2165/11591310-000000000-00000. Drugs Aging. 2011. PMID: 21639405 Review.
Those phytochemicals discussed include the alkaloid physostigmine, a ChEI from the calabar bean (Physostigma venenosum), which has been used as a template for the development of synthetic derivatives that inhibit acetylcholinesterase, including the drug rivastigmine …
Those phytochemicals discussed include the alkaloid physostigmine, a ChEI from the calabar bean (Physostigma venenosum), which …
Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis.
Yan LH, Li X, Wang BG. Yan LH, et al. Nat Prod Rep. 2023 Dec 13;40(12):1874-1900. doi: 10.1039/d3np00023k. Nat Prod Rep. 2023. PMID: 37642299 Review.
Since the discovery of geneserine, the first 1,2-oxazine-containing natural product (1,2-oxazine NP) being isolated from Calabar bean (Physostigma venenosum) in 1925, a total of 76 naturally occurring 1,2-oxazine NPs have been isolated and identified from various so …
Since the discovery of geneserine, the first 1,2-oxazine-containing natural product (1,2-oxazine NP) being isolated from Calabar bean (Ph …
22 results