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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1905 1
1910 1
1915 1
1924 1
1935 1
1943 1
1944 1
1945 5
1946 13
1947 16
1948 12
1949 12
1950 20
1951 18
1952 21
1953 19
1954 24
1955 26
1956 15
1957 15
1958 18
1959 10
1960 15
1961 15
1962 44
1963 86
1964 120
1965 101
1966 125
1967 145
1968 152
1969 143
1970 163
1971 179
1972 195
1973 197
1974 215
1975 179
1976 193
1977 193
1978 165
1979 174
1980 162
1981 158
1982 186
1983 167
1984 145
1985 176
1986 186
1987 167
1988 192
1989 185
1990 185
1991 198
1992 154
1993 157
1994 129
1995 125
1996 96
1997 123
1998 111
1999 95
2000 105
2001 78
2002 73
2003 69
2004 66
2005 73
2006 74
2007 80
2008 68
2009 55
2010 62
2011 69
2012 70
2013 71
2014 44
2015 49
2016 41
2017 41
2018 46
2019 42
2020 36
2021 45
2022 28
2023 36
2024 9

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7,419 results

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Page 1
Treatment of Anticholinergic Delirium with Oral Rivastigmine: A Case Report.
Karousatos C, Murphy L. Karousatos C, et al. J Emerg Med. 2024 Mar 16:S0736-4679(24)00084-2. doi: 10.1016/j.jemermed.2024.03.017. Online ahead of print. J Emerg Med. 2024. PMID: 38658202
BACKGROUND: Anticholinergic toxicity is commonly encountered in the emergency department. However, the availability of physostigmine, a central acetylcholinesterase inhibitor used to reverse anticholinergic delirium, has been significantly limited due to national drug shor …
BACKGROUND: Anticholinergic toxicity is commonly encountered in the emergency department. However, the availability of physostigmine, …
Anticholinergic Toxidrome due to Thorn Apple Seed Ingestion in an Elderly Couple.
van Gastel P, Dijkstra JN, Jacob MA, Schouten JA, Kok B. van Gastel P, et al. Eur J Case Rep Intern Med. 2024 Mar 28;11(4):004381. doi: 10.12890/2024_004381. eCollection 2024. Eur J Case Rep Intern Med. 2024. PMID: 38584905 Free PMC article.
CONCLUSION: Anticholinergic syndrome consists of a combination of central and peripheral anticholinergic symptoms. Physostigmine given intravenously resulted in rapid reversal of symptoms. ...LEARNING POINTS: The clinical presentation of an anticholinergic toxidrome includ …
CONCLUSION: Anticholinergic syndrome consists of a combination of central and peripheral anticholinergic symptoms. Physostigmine give …
Rivastigmine for the management of anticholinergic delirium.
Chiew AL, Holford AG, Chan BSH, Isoardi KZ. Chiew AL, et al. Clin Toxicol (Phila). 2024 Feb;62(2):82-87. doi: 10.1080/15563650.2024.2319854. Epub 2024 Mar 11. Clin Toxicol (Phila). 2024. PMID: 38465631
The spectrum of anticholinergic delirium ranges from mild agitation to severe behavioural disturbance. Physostigmine is an effective treatment for anticholinergic delirium, but its availability is limited. ...One patient with a history of epilepsy had a seizure, 1.5 hours …
The spectrum of anticholinergic delirium ranges from mild agitation to severe behavioural disturbance. Physostigmine is an effective …
Improved seizure liability detection by combining rat hippocampal brain slice electrophysiology with in vivo behavior observation following intracerebroventricular drug administration.
Tsubouchi T, Ikeda K, Sasaki Y, Watanabe H, Chihara K, Miyawaki I. Tsubouchi T, et al. J Pharmacol Toxicol Methods. 2024 Mar-Apr;126:107496. doi: 10.1016/j.vascn.2024.107496. Epub 2024 Mar 2. J Pharmacol Toxicol Methods. 2024. PMID: 38432527
A comparative study of seizure liability among carbapenem antibiotics revealed that tienam > carbenin > omegacin and finibax. Despite leading to a strong decrease in PS area, physostigmine, cisplatin, and paroxetine still produced MPSs. Therefore, the increase in PS …
A comparative study of seizure liability among carbapenem antibiotics revealed that tienam > carbenin > omegacin and finibax. Despite …
Safety of Physostigmine for Pediatric Antimuscarinic Poisoning.
Huber S, Avera R, Penfound S, Overberg A, Nañagas K. Huber S, et al. J Med Toxicol. 2024 Jan 24. doi: 10.1007/s13181-024-00988-0. Online ahead of print. J Med Toxicol. 2024. PMID: 38265619
Cases were stratified into groups by therapy received: benzodiazepines alone, benzodiazepines and physostigmine, physostigmine alone, or no physostigmine or benzodiazepines. ...There was no increase in serious outcomes among patients receiving only physost …
Cases were stratified into groups by therapy received: benzodiazepines alone, benzodiazepines and physostigmine, physostigmine …
Role of hippocampal and prefrontal cortical cholinergic transmission in combination therapy valproate and cannabidiol in memory consolidation in rats: involvement of CREB- BDNF signaling pathways.
Fatahi N, Jafari-Sabet M, Vahabzadeh G, Komaki A. Fatahi N, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan 8. doi: 10.1007/s00210-023-02941-4. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38189934
METHODS: One-trial, step-through inhibitory test was used to evaluate memory consolidation in rats. The intra-CA1 injection of physostigmine and atropine was performed to assess the role of cholinergic transmission in this co-administration. ...RESULTS: Post-training intra …
METHODS: One-trial, step-through inhibitory test was used to evaluate memory consolidation in rats. The intra-CA1 injection of physostigm …
Deliberate Self-Poisoning with Plants in Southeastern France, a Poison Center 20-Year Report.
Torrents R, Reynoard J, Glaizal M, Schmitt C, Fabeck KV, Boulamery A, de Haro L, Simon N. Torrents R, et al. Toxins (Basel). 2023 Nov 24;15(12):671. doi: 10.3390/toxins15120671. Toxins (Basel). 2023. PMID: 38133175 Free PMC article. Review.
Through the 262 plants poisonings, 19 patients among the 186 Nerium oleander poisonings received Digifab as an antidote and 1 patient received physostigmine among the 11 Datura poisonings. Only four deaths were reported for this review, each involving Nerium oleander. ...
Through the 262 plants poisonings, 19 patients among the 186 Nerium oleander poisonings received Digifab as an antidote and 1 patient receiv …
Ophthalmic Atropine: A Typical Anticholinergic Toxidrome From an Atypical Old Culprit.
Raschka M, Khant M. Raschka M, et al. J Pediatr Pharmacol Ther. 2023;28(6):565-567. doi: 10.5863/1551-6776-28.6.565. Epub 2023 Oct 28. J Pediatr Pharmacol Ther. 2023. PMID: 38130339 Free PMC article.
Upon identifying that the patient was being treated with atropine ophthalmic drops prior to hospital arrival, a dose of intravenous physostigmine was administered, resulting in complete reversal of all toxidrome symptoms....
Upon identifying that the patient was being treated with atropine ophthalmic drops prior to hospital arrival, a dose of intravenous physo …
[Eserine, in Crooked House and Curtain].
Takao M. Takao M. Brain Nerve. 2023 Dec;75(12):1343-1346. doi: 10.11477/mf.1416202536. Brain Nerve. 2023. PMID: 38097226 Japanese.
Eserine, well-known as physostigmine, is classified as an alkaloid. It is a cholinesterase inhibitor and appears in Agatha Christie's novel entitled, Crooked House and Curtain: Poirot's Last Case. ...
Eserine, well-known as physostigmine, is classified as an alkaloid. It is a cholinesterase inhibitor and appears in Agatha Christie's …
Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus.
Klinger K, Del Ángel M, Çalışkan G, Stork O. Klinger K, et al. Front Aging Neurosci. 2023 Nov 9;15:1283581. doi: 10.3389/fnagi.2023.1283581. eCollection 2023. Front Aging Neurosci. 2023. PMID: 38020778 Free PMC article.
This change in aged males is accompanied by a deficit in theta burst-induced long-term potentiation (LTP) in the medial perforant path-to-dorsal DG (MPP-DG) synapse, which can be rescued by enhancing cholinergic activation with the acetylcholine esterase blocker, physostigmine …
This change in aged males is accompanied by a deficit in theta burst-induced long-term potentiation (LTP) in the medial perforant path-to-do …
7,419 results