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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1971 1
1972 1
1974 1
1975 1
1978 2
1980 1
1981 1
1982 2
1983 1
1985 1
1986 1
1988 2
1989 2
1991 1
1992 1
1993 1
1994 1
1997 2
1999 2
2000 1
2001 1
2002 3
2003 3
2004 5
2005 4
2006 4
2007 9
2008 11
2009 6
2010 8
2011 15
2012 16
2013 21
2014 17
2015 23
2016 23
2017 30
2018 22
2019 33
2020 28
2021 32
2022 26
2023 25
2024 11

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363 results

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Page 1
4-[4-(3-Methoxy-benzamido)phen-oxy]-N-methyl-picolinamide.
Meng NN, Huang TT, Li DK, Zhang WX, Yu LT. Meng NN, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 Jan 30;66(Pt 2):o476. doi: 10.1107/S1600536809055688. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21579885 Free PMC article.
Novel picolinamide-based cystic fibrosis transmembrane regulator modulators: evaluation of WO2013038373, WO2013038376, WO2013038381, WO2013038386 and WO2013038390.
Norman P. Norman P. Expert Opin Ther Pat. 2014 Jul;24(7):829-37. doi: 10.1517/13543776.2014.876412. Epub 2014 Jan 7. Expert Opin Ther Pat. 2014. PMID: 24392786 Review.
Vertex has led the way in developing N-aryl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarboxamide derivatives such as lumacaftor and VX-661, which correct trafficking of delta508CFTR and partially restore chloride channel activity. Novartis had identified similar activity …
Vertex has led the way in developing N-aryl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarboxamide derivatives such as lumacaftor and …
Unconventional Antibacterials and Adjuvants.
Chang M, Mahasenan KV, Hermoso JA, Mobashery S. Chang M, et al. Acc Chem Res. 2021 Feb 16;54(4):917-929. doi: 10.1021/acs.accounts.0c00776. Epub 2021 Jan 29. Acc Chem Res. 2021. PMID: 33512995 Free PMC article.
Attempts at inhibition of the regulatory phosphorylation events identified three classes of antibacterial adjuvants and one class of antibacterials, the picolinamides. The chemical structures for these hits went through diversification by synthesis of hundreds of analogs. …
Attempts at inhibition of the regulatory phosphorylation events identified three classes of antibacterial adjuvants and one class of antibac …
γ-Selective C(sp3)-H amination via controlled migratory hydroamination.
Lee C, Seo H, Jeon J, Hong S. Lee C, et al. Nat Commun. 2021 Sep 27;12(1):5657. doi: 10.1038/s41467-021-25696-z. Nat Commun. 2021. PMID: 34580295 Free PMC article.
A range of amines can be installed at the gamma-C(sp(3))-H bond of unactivated alkenes with varying alkyl chain lengths, enabling late-stage access to value-added gamma-aminated products. Moreover, by employing picolinamide-coupled alkene substrates, this approach is furth …
A range of amines can be installed at the gamma-C(sp(3))-H bond of unactivated alkenes with varying alkyl chain lengths, enabling late-stage …
cis-Bis(azido-κN)bis-(pyridine-2-carbox-amide-κN,O)nickel(II).
Daković M, Popović Z. Daković M, et al. Acta Crystallogr Sect E Struct Rep Online. 2008 Jan 9;64(Pt 2):m311-2. doi: 10.1107/S1600536808000299. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21201283 Free PMC article.
The title compound, [Ni(N(3))(2)(C(6)H(6)N(2)O)(2)], was obtained as the first crystalline product from the reaction of Ni(NO(3))(2).6H(2)O, picolinamide and NaN(3) in aqueous media. After a few days in the mother liquor, crystals of the cis isomer transformed into the tra …
The title compound, [Ni(N(3))(2)(C(6)H(6)N(2)O)(2)], was obtained as the first crystalline product from the reaction of Ni(NO(3))(2).6H(2)O, …
Pd-Catalyzed Picolinamide-Directed Late-Stage Chalcogenation of Tryptophan-Containing Peptides.
Bag R, Sharma NK. Bag R, et al. J Org Chem. 2023 Nov 17;88(22):15666-15686. doi: 10.1021/acs.joc.3c01657. Epub 2023 Oct 26. J Org Chem. 2023. PMID: 37883335
It comprises broad substrate scope, functional group diversity, late-stage modification of drug molecules, and various valuable synthetic transformations, including room temperature easy removal of the picolinamide auxiliary, which could be applicable to tune the structure …
It comprises broad substrate scope, functional group diversity, late-stage modification of drug molecules, and various valuable synthetic tr …
New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties.
Stankiewicz A, Kaczorowska K, Bugno R, Kozioł A, Paluchowska MH, Burnat G, Chruścicka B, Chorobik P, Brański P, Wierońska JM, Duszyńska B, Pilc A, Bojarski AJ. Stankiewicz A, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):211-225. doi: 10.1080/14756366.2021.1998022. J Enzyme Inhib Med Chem. 2022. PMID: 34894953 Free PMC article.
The most potent in vitro mGlu(4) PAM derivative 52 (N-(3-chloro-4-(5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl)phenyl)picolinamide) was readily absorbed after i.p. administration (male Albino Swiss mice) and reached a maximum brain concentration of 949.76 ng/mL. ...Promising d …
The most potent in vitro mGlu(4) PAM derivative 52 (N-(3-chloro-4-(5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl)phenyl)picolinamide) was r …
3,6-Dichloro-N-(4-fluoro-phen-yl)picolinamide.
Tan Z, Bing Y, Fang S, Kai Z, Yan Y. Tan Z, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Jul 4;65(Pt 8):o1758. doi: 10.1107/S1600536809024799. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21583468 Free PMC article.
363 results