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Did you mean picrotoxin (6,288 results)?
Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors.
Wang DS, Buckinx R, Lecorronc H, Mangin JM, Rigo JM, Legendre P. Wang DS, et al. J Biol Chem. 2007 Jun 1;282(22):16016-35. doi: 10.1074/jbc.M701502200. Epub 2007 Apr 3. J Biol Chem. 2007. PMID: 17405877 Free article.
Although both picrotoxinin and picrotin inhibited glycine-evoked outside-out currents, picrotin had a 30 times higher IC50 than picrotoxinin. Picrotin-evoked inhibition displayed voltage dependence, whereas picrotoxinin did not. ...
Although both picrotoxinin and picrotin inhibited glycine-evoked outside-out currents, picrotin had a 30 times higher IC50 tha …
Gating effects on picrotin block of glycine receptors.
Li P, Slaughter MM. Li P, et al. Neuroreport. 2012 Dec 5;23(17):1017-20. doi: 10.1097/WNR.0b013e32835a8629. Neuroreport. 2012. PMID: 23079787
The effect of subunit gating properties on block of the inhibitory glycine receptor (GlyR) was explored using heteromeric alpha subunit expression in voltage-clamped HEK293 cells. The alpha2 GlyR is more sensitive to picrotin block than the alpha1 GlyR, and this difference …
The effect of subunit gating properties on block of the inhibitory glycine receptor (GlyR) was explored using heteromeric alpha subunit expr …
A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore.
Yang Z, Cromer BA, Harvey RJ, Parker MW, Lynch JW. Yang Z, et al. J Neurochem. 2007 Oct;103(2):580-9. doi: 10.1111/j.1471-4159.2007.04850.x. Epub 2007 Aug 20. J Neurochem. 2007. PMID: 17714449 Free article.
Picrotoxin, an antagonist of structurally-rated GABA(A) receptors (GABA(A)Rs) and glycine receptors (GlyRs), is an equimolar mixture of picrotoxinin (PTXININ) and picrotin (PTN). These compounds share a common structure except that PTN contains a slightly larger dimethylme …
Picrotoxin, an antagonist of structurally-rated GABA(A) receptors (GABA(A)Rs) and glycine receptors (GlyRs), is an equimolar mixture of picr …
Two new picrotoxane-type sesquiterpenoid lactones from Dendrobium williamsonii.
Yang M, Chen LJ, Zhang Y, Chen YG. Yang M, et al. J Asian Nat Prod Res. 2019 Feb;21(2):129-133. doi: 10.1080/10286020.2017.1394294. Epub 2017 Oct 25. J Asian Nat Prod Res. 2019. PMID: 29069925
Two new picrotoxane-type sesquiterpenoid lactones, dendrowillins A (1) and B (2), together with five known sesquiterpenoids, (-)-picrotin (3), alpha-dihydropicrotoxinin (4), dendronobilin B (5), amoenin (6), and (-)-10beta,13,14-trihydroxyalloaromadendrane (7), were isolat …
Two new picrotoxane-type sesquiterpenoid lactones, dendrowillins A (1) and B (2), together with five known sesquiterpenoids, (-)-picrotin …
Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region.
Steinbach JH, Bracamontes J, Yu L, Zhang P, Covey DF. Steinbach JH, et al. Mol Pharmacol. 2000 Jul;58(1):11-7. doi: 10.1124/mol.58.1.11. Mol Pharmacol. 2000. PMID: 10860922
Blocking of alpha3 receptors by picrotin is reduced in the presence of alphaEMTBL, indicating that the mechanisms interact at some point, but the mutation alpha3 A254G does not remove block by picrotin. However, mutation of a nearby residue alpha3 T258F does remove …
Blocking of alpha3 receptors by picrotin is reduced in the presence of alphaEMTBL, indicating that the mechanisms interact at some po …
Glycine receptor subunit composition alters the action of GABA antagonists.
Li P, Slaughter M. Li P, et al. Vis Neurosci. 2007 Jul-Aug;24(4):513-21. doi: 10.1017/S0952523807070368. Epub 2007 Jul 23. Vis Neurosci. 2007. PMID: 17659095
Picrotin, which has been reported to be inactive at GABA receptors, blocks glycine currents in retina and in HEK293 cells, suggesting its utility as a selective glycine antagonist. However, picrotin is a more potent inhibitor of GABA than glycine in retinal neurons. …
Picrotin, which has been reported to be inactive at GABA receptors, blocks glycine currents in retina and in HEK293 cells, suggesting …
Picrotoxin as a potent inducer of rat hepatic cytochrome P450, CYP2B1 and CYP2B2.
Yamada H, Fujisaki H, Kaneko H, Ishii Y, Hamaguchi T, Oguri K. Yamada H, et al. Biochem Pharmacol. 1993 May 5;45(9):1783-9. doi: 10.1016/0006-2952(93)90434-x. Biochem Pharmacol. 1993. PMID: 8494537
Supporting these results, immunoblot analysis showed that CYP2B1 and 2B2 proteins in the liver microsomes were increased by picrotoxin Picrotoxinin and picrotin, which are components of the picrotoxin molecule, had the same ability to induce the hepatic activity of benzphe …
Supporting these results, immunoblot analysis showed that CYP2B1 and 2B2 proteins in the liver microsomes were increased by picrotoxin Picro …
Untargeted serum metabolomic profiling for early detection of Schistosoma mekongi infection in mouse model.
Chienwichai P, Nogrado K, Tipthara P, Tarning J, Limpanont Y, Chusongsang P, Chusongsang Y, Tanasarnprasert K, Adisakwattana P, Reamtong O. Chienwichai P, et al. Front Cell Infect Microbiol. 2022 Aug 18;12:910177. doi: 10.3389/fcimb.2022.910177. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36061860 Free PMC article.
Three compounds were identified as potential biomarkers at the early stage of the disease: heptadecanoyl ethanolamide; picrotin; and theophylline. The levels of these three compounds changed significantly during early-stage infection, and therefore these molecules may be p …
Three compounds were identified as potential biomarkers at the early stage of the disease: heptadecanoyl ethanolamide; picrotin; and …
25 results