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SINEUP non-coding RNA activity depends on specific N6-methyladenosine nucleotides.
Pierattini B, D'Agostino S, Bon C, Peruzzo O, Alendar A, Codino A, Ros G, Persichetti F, Sanges R, Carninci P, Santoro C, Espinoza S, Valentini P, Pandolfini L, Gustincich S. Pierattini B, et al. Mol Ther Nucleic Acids. 2023 Apr 7;32:402-414. doi: 10.1016/j.omtn.2023.04.002. eCollection 2023 Jun 13. Mol Ther Nucleic Acids. 2023. PMID: 37187707 Free PMC article.
SINEUP non-coding RNAs rescue defective frataxin expression and activity in a cellular model of Friedreich's Ataxia.
Bon C, Luffarelli R, Russo R, Fortuni S, Pierattini B, Santulli C, Fimiani C, Persichetti F, Cotella D, Mallamaci A, Santoro C, Carninci P, Espinoza S, Testi R, Zucchelli S, Condò I, Gustincich S. Bon C, et al. Among authors: pierattini b. Nucleic Acids Res. 2019 Nov 18;47(20):10728-10743. doi: 10.1093/nar/gkz798. Nucleic Acids Res. 2019. PMID: 31584077 Free PMC article.
Towards SINEUP-based therapeutics: Design of an in vitro synthesized SINEUP RNA.
Valentini P, Pierattini B, Zacco E, Mangoni D, Espinoza S, Webster NA, Andrews B, Carninci P, Tartaglia GG, Pandolfini L, Gustincich S. Valentini P, et al. Among authors: pierattini b. Mol Ther Nucleic Acids. 2022 Feb 2;27:1092-1102. doi: 10.1016/j.omtn.2022.01.021. eCollection 2022 Mar 8. Mol Ther Nucleic Acids. 2022. PMID: 35228902 Free PMC article.
SINEUPs: a novel toolbox for RNA therapeutics.
Espinoza S, Bon C, Valentini P, Pierattini B, Matey AT, Damiani D, Pulcrano S, Sanges R, Persichetti F, Takahashi H, Carninci P, Santoro C, Cotella D, Gustincich S. Espinoza S, et al. Among authors: pierattini b. Essays Biochem. 2021 Oct 27;65(4):775-789. doi: 10.1042/EBC20200114. Essays Biochem. 2021. PMID: 34623427 Free PMC article. Review.