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Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells.
Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, Barragan-Bradford D, Higuera A, Pinilla-Vera M, Short SA, Arciniegas-Rubio A, Tamura T, Leaf DE, Baron RM, Shay T, Brenner MB. Kim EY, et al. J Clin Invest. 2020 Jun 1;130(6):3238-3252. doi: 10.1172/JCI128075. J Clin Invest. 2020. PMID: 32154791 Free PMC article.
Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19.
Reyes M, Filbin MR, Bhattacharyya RP, Sonny A, Mehta A, Billman K, Kays KR, Pinilla-Vera M, Benson ME, Cosimi LA, Hung DT, Levy BD, Villani AC, Sade-Feldman M, Baron RM, Goldberg MB, Blainey PC, Hacohen N. Reyes M, et al. bioRxiv [Preprint]. 2020 Sep 2:2020.09.02.280180. doi: 10.1101/2020.09.02.280180. bioRxiv. 2020. PMID: 32908980 Free PMC article. Updated. Preprint.
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.
Reyes M, Filbin MR, Bhattacharyya RP, Sonny A, Mehta A, Billman K, Kays KR, Pinilla-Vera M, Benson ME, Cosimi LA, Hung DT, Levy BD, Villani AC, Sade-Feldman M, Baron RM, Goldberg MB, Blainey PC, Hacohen N. Reyes M, et al. Sci Transl Med. 2021 Jun 16;13(598):eabe9599. doi: 10.1126/scitranslmed.abe9599. Epub 2021 Jun 8. Sci Transl Med. 2021. PMID: 34103408 Free PMC article.
Empirical Assessment of U.S. Coronavirus Disease 2019 Crisis Standards of Care Guidelines.
Bharadwaj M, Jezmir JL, Kishore SP, Winkler M, Diephus B, Haider H, Crowley CP, Pinilla-Vera M, Varon J, Baron RM, Feldman WB, Kim EY. Bharadwaj M, et al. Among authors: pinilla vera m. Crit Care Explor. 2021 Jul 15;3(7):e0496. doi: 10.1097/CCE.0000000000000496. eCollection 2021 Jul. Crit Care Explor. 2021. PMID: 34286282 Free PMC article.
A targetable 'rogue' neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS.
Herrera VLM, Walkey AJ, Nguyen MQ, Gromisch CM, Mosaddhegi JZ, Gromisch MS, Jundi B, Lukassen S, Carstensen S, Denis R, Belkina AC, Baron RM, Pinilla-Vera M, Mueller M, Kimberly WT, Goldstein JN, Lehmann I, Shih AR, Eils R, Levy BD, Ruiz-Opazo N. Herrera VLM, et al. Among authors: pinilla vera m. Sci Rep. 2022 Apr 4;12(1):5583. doi: 10.1038/s41598-022-09343-1. Sci Rep. 2022. PMID: 35379853 Free PMC article.
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