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Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations.
Nicolaou KC, Wang Y, Lu M, Mandal D, Pattanayak MR, Yu R, Shah AA, Chen JS, Zhang H, Crawford JJ, Pasunoori L, Poudel YB, Chowdari NS, Pan C, Nazeer A, Gangwar S, Vite G, Pitsinos EN. Nicolaou KC, et al. Among authors: pitsinos en. J Am Chem Soc. 2016 Jul 6;138(26):8235-46. doi: 10.1021/jacs.6b04339. Epub 2016 Jun 27. J Am Chem Soc. 2016. PMID: 27266267
Total Synthesis and Full Structural Assignment of Namenamicin.
Nicolaou KC, Li R, Lu Z, Pitsinos EN, Alemany LB. Nicolaou KC, et al. Among authors: pitsinos en. J Am Chem Soc. 2018 Jul 5;140(26):8091-8095. doi: 10.1021/jacs.8b04592. Epub 2018 Jun 22. J Am Chem Soc. 2018. PMID: 29932325
Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents.
Nicolaou KC, Li R, Lu Z, Pitsinos EN, Alemany LB, Aujay M, Lee C, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. Among authors: pitsinos en. J Am Chem Soc. 2018 Sep 26;140(38):12120-12136. doi: 10.1021/jacs.8b06955. Epub 2018 Sep 14. J Am Chem Soc. 2018. PMID: 30216054
DNA Binding and Cleavage Modes of Shishijimicin A.
Zhang H, Li R, Ba S, Lu Z, Pitsinos EN, Li T, Nicolaou KC. Zhang H, et al. Among authors: pitsinos en. J Am Chem Soc. 2019 May 15;141(19):7842-7852. doi: 10.1021/jacs.9b01800. Epub 2019 May 3. J Am Chem Soc. 2019. PMID: 31050893
Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug Conjugates.
Nicolaou KC, Li R, Chen Q, Lu Z, Pitsinos EN, Schammel A, Lin B, Gu C, Sarvaiya H, Tchelepi R, Valdiosera A, Clubb J, Barbour N, Sisodiya V, Sandoval J, Lee C, Aujay M, Gavrilyuk J. Nicolaou KC, et al. Among authors: pitsinos en. J Am Chem Soc. 2020 Jul 22;142(29):12890-12899. doi: 10.1021/jacs.0c06554. Epub 2020 Jul 14. J Am Chem Soc. 2020. PMID: 32662641
Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect.
Nicolaou KC, Rigol S, Pitsinos EN, Das D, Lu Y, Rout S, Schammel AW, Holte D, Lin B, Gu C, Sarvaiya H, Trinidad J, Barbour N, Valdiosera AM, Sandoval J, Lee C, Aujay M, Fernando H, Dhar A, Karsunky H, Taylor N, Pysz M, Gavrilyuk J. Nicolaou KC, et al. Among authors: pitsinos en. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2107042118. doi: 10.1073/pnas.2107042118. Proc Natl Acad Sci U S A. 2021. PMID: 34155147 Free PMC article.
27 results