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Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop.
Giannelli V, Fontana MR, Giuliani MM, Guangcai D, Rappuoli R, Pizza M. Giannelli V, et al. Among authors: pizza m. Infect Immun. 1997 Jan;65(1):331-4. doi: 10.1128/iai.65.1.331-334.1997. Infect Immun. 1997. PMID: 8975934 Free PMC article.
To generate nontoxic derivatives of Escherichia coli heat-labile enterotoxin (LT), site-directed mutagenesis has been used to change either the amino acid residues located in the catalytic site (M. Pizza, M. Domenighini, W. Hol, V. Giannelli, M. R. Fon …
To generate nontoxic derivatives of Escherichia coli heat-labile enterotoxin (LT), site-directed mutagenesis has been used to change either …
Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant.
Marchetti M, Rossi M, Giannelli V, Giuliani MM, Pizza M, Censini S, Covacci A, Massari P, Pagliaccia C, Manetti R, Telford JL, Douce G, Dougan G, Rappuoli R, Ghiara P. Marchetti M, et al. Among authors: pizza m. Vaccine. 1998 Jan;16(1):33-7. doi: 10.1016/s0264-410x(97)00153-9. Vaccine. 1998. PMID: 9607006
Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing.
Pizza M, Scarlato V, Masignani V, Giuliani MM, Aricò B, Comanducci M, Jennings GT, Baldi L, Bartolini E, Capecchi B, Galeotti CL, Luzzi E, Manetti R, Marchetti E, Mora M, Nuti S, Ratti G, Santini L, Savino S, Scarselli M, Storni E, Zuo P, Broeker M, Hundt E, Knapp B, Blair E, Mason T, Tettelin H, Hood DW, Jeffries AC, Saunders NJ, Granoff DM, Venter JC, Moxon ER, Grandi G, Rappuoli R. Pizza M, et al. Science. 2000 Mar 10;287(5459):1816-20. doi: 10.1126/science.287.5459.1816. Science. 2000. PMID: 10710308
LTK63 and LTR72, two mucosal adjuvants ready for clinical trials.
Pizza M, Giuliani MM, Fontana MR, Douce G, Dougan G, Rappuoli R. Pizza M, et al. Int J Med Microbiol. 2000 Oct;290(4-5):455-61. doi: 10.1016/S1438-4221(00)80064-8. Int J Med Microbiol. 2000. PMID: 11111926 Review. No abstract available.
277 results