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1999 1
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Page 1
Primary cilia TRP channel regulates hippocampal excitability.
Vien TN, Ta MC, Kimura LF, Onay T, DeCaen PG. Vien TN, et al. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2219686120. doi: 10.1073/pnas.2219686120. Epub 2023 May 22. Proc Natl Acad Sci U S A. 2023. PMID: 37216541 Free PMC article.
Polycystins (PKD2, PKD2L1, and PKD2L2) are members of the transient receptor potential family, which form ciliary ion channels. ...
Polycystins (PKD2, PKD2L1, and PKD2L2) are members of the transient receptor potential family, which form ciliary ion channels. ...
Expression of Pkd2l2 in testis is implicated in spermatogenesis.
Chen Y, Zhang Z, Lv XY, Wang YD, Hu ZG, Sun H, Tan RZ, Liu YH, Bian GH, Xiao Y, Li QW, Yang QT, Ai JZ, Feng L, Yang Y, Wei YQ, Zhou Q. Chen Y, et al. Biol Pharm Bull. 2008 Aug;31(8):1496-500. doi: 10.1248/bpb.31.1496. Biol Pharm Bull. 2008. PMID: 18670078 Free article.
Pkd2l2 is a novel member of the polycystic kidney disease (PKD) gene family in mammals. ...Overexpression of Pkd2l2 increased the intracellular calcium concentration of MDCK cells, as detected by flow cytometry. ...
Pkd2l2 is a novel member of the polycystic kidney disease (PKD) gene family in mammals. ...Overexpression of Pkd2l2 increased …
Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.
Wu X, Indzhykulian AA, Niksch PD, Webber RM, Garcia-Gonzalez M, Watnick T, Zhou J, Vollrath MA, Corey DP. Wu X, et al. PLoS One. 2016 May 19;11(5):e0155577. doi: 10.1371/journal.pone.0155577. eCollection 2016. PLoS One. 2016. PMID: 27196058 Free PMC article.
We then characterized mice lacking functional Trpm2, Pkd2, Pkd2l1, Pkd2l2 and Pkd1l3, using scanning electron microscopy, auditory brainstem response, permeant dye accumulation, and single-cell electrophysiology. ...
We then characterized mice lacking functional Trpm2, Pkd2, Pkd2l1, Pkd2l2 and Pkd1l3, using scanning electron microscopy, auditory br …
Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization.
Guo L, Schreiber TH, Weremowicz S, Morton CC, Lee C, Zhou J. Guo L, et al. Genomics. 2000 Mar 15;64(3):241-51. doi: 10.1006/geno.2000.6131. Genomics. 2000. PMID: 10756092
In this study, we describe a fifth member of the family, polycystin-L2, encoded by PKD2L2 in human and Pkd2l2 in mouse. Full-length cDNA sequences for both mouse and human polycystin-L2 were obtained from testis cDNA. ...PKD2L2 was mapped to human chromosome …
In this study, we describe a fifth member of the family, polycystin-L2, encoded by PKD2L2 in human and Pkd2l2 in mouse. Full-l …
Molecular evolution of PKD2 gene family in mammals.
Ye C, Sun H, Guo W, Wei Y, Zhou Q. Ye C, et al. Genetica. 2009 Sep;137(1):77-86. doi: 10.1007/s10709-009-9352-4. Epub 2009 Feb 1. Genetica. 2009. PMID: 19184643
However, positive selection imposed on synonymous sites also potentially contributed to this case. For the paralogs, our results implied that PKD2L2 genes evolved under a weaker purifying selection constraint than PKD2 and PKD2L1 genes. Interestingly, some loop regions of …
However, positive selection imposed on synonymous sites also potentially contributed to this case. For the paralogs, our results implied tha …
Calcium signaling in cilia and ciliary-mediated intracellular calcium signaling: are they independent or coordinated molecular events?
Masyuk AI, Gradilone SA, LaRusso NF. Masyuk AI, et al. Hepatology. 2014 Nov;60(5):1783-5. doi: 10.1002/hep.27331. Epub 2014 Oct 2. Hepatology. 2014. PMID: 25066674 Free PMC article.
The polycystin proteins (PC and PKD), identified in linkage studies of polycystic kidney disease, are candidate channels divided into two structural classes 11-transmembrane proteins (PKD1, PKD1L1 and PKD1L2) remarkable for a large extracellular amino terminus of putative cell ad …
The polycystin proteins (PC and PKD), identified in linkage studies of polycystic kidney disease, are candidate channels divided into two st …
Identification and Characterization of Novel Mutations in Chronic Kidney Disease (CKD) and Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Saudi Subjects by Whole-Exome Sequencing.
Alzahrani OR, Alatwi HE, Alharbi AA, Alessa AH, Al-Amer OM, Alanazi AFR, Shams AM, Alomari E, Naser AY, Alzahrani FA, Hosawi S, Alghamdi SM, Abdali WA, Elfaki I, Hawsawi YM. Alzahrani OR, et al. Medicina (Kaunas). 2022 Nov 16;58(11):1657. doi: 10.3390/medicina58111657. Medicina (Kaunas). 2022. PMID: 36422197 Free PMC article.
Three detected variants were novel, identified at PKD1 (c.1758A > C), PKD2L2 (c.1364A > T), and TSC2 (deletion of a'a at the 3'UTR, R1680C) genes. ...We also reported (to our knowledge) for the first time two novel missense variants in PKD1 and PKD2L2 genes an …
Three detected variants were novel, identified at PKD1 (c.1758A > C), PKD2L2 (c.1364A > T), and TSC2 (deletion of a'a at the 3' …
Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2).
Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ. Veldhuisen B, et al. Eur J Hum Genet. 1999 Dec;7(8):860-72. doi: 10.1038/sj.ejhg.5200383. Eur J Hum Genet. 1999. PMID: 10602361
To identify genes that code for related proteins we searched for homologous sequences in several databases and identified one partial cDNA and two genomic sequences with significant homology to both polycystin-1 and - 2. Further analysis revealed one novel gene, PKD2L2, lo …
To identify genes that code for related proteins we searched for homologous sequences in several databases and identified one partial cDNA a …
Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes.
England SJ, Campbell PC, Banerjee S, Swanson AJ, Lewis KE. England SJ, et al. Front Cell Dev Biol. 2017 Feb 21;5:5. doi: 10.3389/fcell.2017.00005. eCollection 2017. Front Cell Dev Biol. 2017. PMID: 28271061 Free PMC article.
However, in contrast to mammals and cartilaginous and holostei fish, teleosts lack pkd2l2, and pkdrej genes, suggesting that these have been lost in the teleost lineage. ...
However, in contrast to mammals and cartilaginous and holostei fish, teleosts lack pkd2l2, and pkdrej genes, suggesting that these ha …
16 results