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1998 1
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2012 6
2013 3
2014 1
2015 5
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2017 5
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Page 1
Genome-wide association study identifies a new susceptibility locus in PLA2G4C for Multiple System Atrophy.
Nakahara Y, Mitsui J, Date H, Porto KJ, Hayashi Y, Yamashita A, Kusakabe Y, Matsukawa T, Ishiura H, Yasuda T, Iwata A, Goto J, Ichikawa Y, Momose Y, Takahashi Y, Toda T, Ohta R, Yoshimura J, Morishita S, Gustavsson EK, Christy D, Maczis M, Farrer MJ, Kim HJ, Park SS, Jeon B, Zhang J, Gu W, Scholz SW, Singleton AB, Houlden H, Yabe I, Sasaki H, Matsushima M, Takashima H, Kikuchi A, Aoki M, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Ito M, Sobue G, Ishikawa K, Mizusawa H, Kanai K, Kuwabara S, Arai K, Koyano S, Kuroiwa Y, Hasegawa K, Yuasa T, Yasui K, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Kusunoki S, Osaki Y, Horiuchi M, Yamamoto K, Shimada M, Miyagawa T, Kawai Y, Nishida N, Tokunaga K, Dürr A, Brice A, Filla A, Klockgether T, Wüllner U, Tanner CM, Kukull WA, Lee VM, Masliah E, Low PA, Sandroni P, Ozelius L, Foroud T, Tsuji S. Nakahara Y, et al. medRxiv [Preprint]. 2023 May 2:2023.05.02.23289328. doi: 10.1101/2023.05.02.23289328. medRxiv. 2023. PMID: 37425910 Free PMC article. Preprint.
Odds ratio=1.14; 95% CI 1.02 to 1.28) despite allele frequencies being quite different between these populations. rs2303744 leads to an amino acid substitution in PLA2G4C that encodes the cPLA2gamma lysophospholipase/transacylase. ...
Odds ratio=1.14; 95% CI 1.02 to 1.28) despite allele frequencies being quite different between these populations. rs2303744 leads to an amin …
Augmented Pla2g4c/Ptgs2/Hpgds axis in bronchial smooth muscle tissues of experimental asthma.
Chiba Y, Suto W, Sakai H. Chiba Y, et al. PLoS One. 2018 Aug 30;13(8):e0202623. doi: 10.1371/journal.pone.0202623. eCollection 2018. PLoS One. 2018. PMID: 30161143 Free PMC article.
Validation of DEGs by quantitative RT-PCR showed a significant increase in PLA2 group 4c (Pla2g4c)/COX-2 (Ptgs2)/PGD2 synthase 2 (Hpgds) axis. PGD2 level in bronchoalveolar fluids of the OA-challenged mice was significantly increased. ...
Validation of DEGs by quantitative RT-PCR showed a significant increase in PLA2 group 4c (Pla2g4c)/COX-2 (Ptgs2)/PGD2 synthase 2 (Hpg …
Prognostic significance of PLA2G4C gene polymorphism in patients with stage II colorectal cancer.
Olsen RS, Andersson RE, Zar N, Löfgren S, Wågsäter D, Matussek A, Dimberg J. Olsen RS, et al. Acta Oncol. 2016;55(4):474-9. doi: 10.3109/0284186X.2015.1073350. Epub 2015 Sep 12. Acta Oncol. 2016. PMID: 26364726
BACKGROUND: Phospholipase A2 Group IV C (PLA2G4C) catalyzes the release of certain fatty acids from phospholipids and plays a role in a range of physiological functions, such as remodeling of cell membranes and the production of prostaglandins. Furthermore, it has been pro …
BACKGROUND: Phospholipase A2 Group IV C (PLA2G4C) catalyzes the release of certain fatty acids from phospholipids and plays a role in …
Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas.
Hartmann C, Johnk L, Sasaki H, Jenkins RB, Louis DN. Hartmann C, et al. Brain Pathol. 2002 Apr;12(2):178-82. doi: 10.1111/j.1750-3639.2002.tb00432.x. Brain Pathol. 2002. PMID: 11958371 Free PMC article.
PLA2G4C, encoding cytosolic phospholipase A2-gamma (cPLA2-gamma), is a 17-exon gene located on chromosome 19q13.3 within the putative glioma tumor suppressor gene region. ...These characteristics suggest that the PLA2G4C polymorphism will be a convenient and practic …
PLA2G4C, encoding cytosolic phospholipase A2-gamma (cPLA2-gamma), is a 17-exon gene located on chromosome 19q13.3 within the putative …
Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation.
Su X, Liu S, Zhang X, Lam SM, Hu X, Zhou Y, Chen J, Wang Y, Wu C, Shui G, Lu M, Pei R, Chen X. Su X, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jul;1862(7):692-705. doi: 10.1016/j.bbalip.2017.03.007. Epub 2017 Mar 21. Biochim Biophys Acta Mol Cell Biol Lipids. 2017. PMID: 28336330
Here we further revealed that PLA2G4C plays an important role in LD biogenesis and refined the functional analysis of PLA2G4C in LD biogenesis and HCV assembly. ...Mutant PLA2G4C without enzymatic activity was not able to restore LD formation in PLA2G4C …
Here we further revealed that PLA2G4C plays an important role in LD biogenesis and refined the functional analysis of PLA2G4C …
Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients.
Nadalin S, Radović I, Buretić-Tomljanović A. Nadalin S, et al. Prostaglandins Leukot Essent Fatty Acids. 2015 Sep;100:29-32. doi: 10.1016/j.plefa.2015.06.004. Epub 2015 Jun 26. Prostaglandins Leukot Essent Fatty Acids. 2015. PMID: 26160611
We hypothesized that attenuated niacin skin flushing in schizophrenia patients might be associated with polymorphic variants in PLA2G6 and PLA2G4C genes (rs4375 and rs1549637 variations) which encode calcium-independent phospholipase A2 beta (iPLA2beta) and cytosolic phosp …
We hypothesized that attenuated niacin skin flushing in schizophrenia patients might be associated with polymorphic variants in PLA2G6 and …
The rs251684 Variant of PLA2G4C Is Associated with Autism Spectrum Disorder in the Northeast Han Chinese Population.
Liu S, Qiu S, Lu Y, Kanu JS, Li R, Bai Y, Zhu X, Lei J, Xu N, Yu Y, Liu Y, Jiang H. Liu S, et al. Genet Test Mol Biomarkers. 2016 Dec;20(12):747-752. doi: 10.1089/gtmb.2016.0195. Epub 2016 Sep 9. Genet Test Mol Biomarkers. 2016. PMID: 27611910
AIM: To investigate the association between autism spectrum disorder (ASD) and the phospholipase A2 group IVC (PLA2G4C) and phospholipase A2 group XIIA (PLA2G12A) polymorphisms in the Northeast Han Chinese population. ...Moreover, we found no preference in the transmission …
AIM: To investigate the association between autism spectrum disorder (ASD) and the phospholipase A2 group IVC (PLA2G4C) and phospholi …
Molecular-genetic pathways of hepatitis C virus regulation of the expression of cellular factors PREB and PLA2G4C, which play an important role in virus replication.
Mishchenko EL, Makarova AA, Antropova EA, Venzel AS, Ivanisenko TV, Demenkov PS, Ivanisenko VA. Mishchenko EL, et al. Vavilovskii Zhurnal Genet Selektsii. 2023 Dec;27(7):776-783. doi: 10.18699/VJGB-23-90. Vavilovskii Zhurnal Genet Selektsii. 2023. PMID: 38213698 Free PMC article.
The expression of PREB and PLA2G4C was significantly elevated in the presence of the HCV genome. ...We assumed that NS3 could inhibit the function of host transcription factor (TF) NOTCH1 by protein-protein interaction, leading to upregulation of PREB and PLA2G4C. A …
The expression of PREB and PLA2G4C was significantly elevated in the presence of the HCV genome. ...We assumed that NS3 could inhibit …
An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population.
Nadalin S, Buretić-Tomljanović A. Nadalin S, et al. Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:57-59. doi: 10.1016/j.plefa.2017.06.003. Epub 2017 Jun 14. Prostaglandins Leukot Essent Fatty Acids. 2017. PMID: 28651698
The combined PLA2G6/PLA2G4C heterozygosity was associated with about a two-fold higher schizophrenia risk. ...The PLA2G4C polymorphism accounted for approximately 12% of negative symptom severity; whereas, the PLA2G6/PLA2G4C interaction contributed to a simil …
The combined PLA2G6/PLA2G4C heterozygosity was associated with about a two-fold higher schizophrenia risk. ...The PLA2G4C poly …
Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth.
Plunkett J, Doniger S, Morgan T, Haataja R, Hallman M, Puttonen H, Menon R, Kuczynski E, Norwitz E, Snegovskikh V, Palotie A, Peltonen L, Fellman V, DeFranco EA, Chaudhari BP, Oates J, Boutaud O, McGregor TL, McElroy JJ, Teramo K, Borecki I, Fay JC, Muglia LJ. Plunkett J, et al. BMC Med Genomics. 2010 Dec 24;3:62. doi: 10.1186/1755-8794-3-62. BMC Med Genomics. 2010. PMID: 21184677 Free PMC article.
METHODS: We performed a comparative genomics screen of highly conserved noncoding elements and identified PLA2G4C, a phospholipase A isoform involved in prostaglandin biosynthesis as human accelerated. ...Additionally, rs11564620 (Thr360Pro) was associated with increased m …
METHODS: We performed a comparative genomics screen of highly conserved noncoding elements and identified PLA2G4C, a phospholipase A …
58 results