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Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors.
Zhang H, Zhou S, Plewka J, Wu C, Zhu M, Yu Q, Musielak B, Wang X, Awadasseid A, Magiera-Mularz K, Wu Y, Zhang W. Zhang H, et al. Among authors: plewka j. J Med Chem. 2023 Aug 10;66(15):10579-10603. doi: 10.1021/acs.jmedchem.3c00731. Epub 2023 Jul 26. J Med Chem. 2023. PMID: 37496104
Antibody Binding Heterogeneity of Protein A Resins.
da Silva GFL, Plewka J, Tscheließnig R, Lichtenegger H, Jungbauer A, Dias-Cabral ACM. da Silva GFL, et al. Among authors: plewka j. Biotechnol J. 2019 Aug;14(8):e1800632. doi: 10.1002/biot.201800632. Epub 2019 May 20. Biotechnol J. 2019. PMID: 30945463
A bacteriophage mimic of the bacterial nucleoid-associated protein Fis.
Chakraborti S, Balakrishnan D, Trotter AJ, Gittens WH, Yang AWH, Jolma A, Paterson JR, Świątek S, Plewka J, Curtis FA, Bowers LY, Pålsson LO, Hughes TR, Taube M, Kozak M, Heddle JG, Sharples GJ. Chakraborti S, et al. Among authors: plewka j. Biochem J. 2020 Apr 17;477(7):1345-1362. doi: 10.1042/BCJ20200146. Biochem J. 2020. PMID: 32207815 Free PMC article.
TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition.
Roganowicz MD, Komurlu S, Mukherjee S, Plewka J, Alam SL, Skorupka KA, Wan Y, Dawidowski D, Cafiso DS, Ganser-Pornillos BK, Campbell EM, Pornillos O. Roganowicz MD, et al. Among authors: plewka j. PLoS Pathog. 2017 Oct 17;13(10):e1006686. doi: 10.1371/journal.ppat.1006686. eCollection 2017 Oct. PLoS Pathog. 2017. PMID: 29040325 Free PMC article.
CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?
Musielak B, Kocik J, Skalniak L, Magiera-Mularz K, Sala D, Czub M, Stec M, Siedlar M, Holak TA, Plewka J. Musielak B, et al. Among authors: plewka j. Molecules. 2019 Aug 1;24(15):2804. doi: 10.3390/molecules24152804. Molecules. 2019. PMID: 31374878 Free PMC article.
Di-bromo-Based Small-Molecule Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Konieczny M, Musielak B, Kocik J, Skalniak L, Sala D, Czub M, Magiera-Mularz K, Rodriguez I, Myrcha M, Stec M, Siedlar M, Holak TA, Plewka J. Konieczny M, et al. Among authors: plewka j. J Med Chem. 2020 Oct 8;63(19):11271-11285. doi: 10.1021/acs.jmedchem.0c01260. Epub 2020 Sep 23. J Med Chem. 2020. PMID: 32936638 Free PMC article.
Human and mouse PD-L1: similar molecular structure, but different druggability profiles.
Magiera-Mularz K, Kocik J, Musielak B, Plewka J, Sala D, Machula M, Grudnik P, Hajduk M, Czepiel M, Siedlar M, Holak TA, Skalniak L. Magiera-Mularz K, et al. Among authors: plewka j. iScience. 2020 Dec 24;24(1):101960. doi: 10.1016/j.isci.2020.101960. eCollection 2021 Jan 22. iScience. 2020. PMID: 33437940 Free PMC article.
39 results