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PMPCB Silencing Sensitizes HCC Tumor Cells to Sorafenib Therapy.
Zheng JF, He S, Zeng Z, Gu X, Cai L, Qi G. Zheng JF, et al. Mol Ther. 2019 Oct 2;27(10):1784-1795. doi: 10.1016/j.ymthe.2019.06.014. Epub 2019 Jul 5. Mol Ther. 2019. PMID: 31337603 Free PMC article.
Here, we investigated the contributory role of the beta subunit of PMPC (PMPCB) in sorafenib resistance. Silencing PMPCB increased HCC tumor cell susceptibility to sorafenib therapy, decreased liver tumor burden, and improved survival of tumor-bearing mice receiving …
Here, we investigated the contributory role of the beta subunit of PMPC (PMPCB) in sorafenib resistance. Silencing PMPCB incre …
Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM(+) Hepatocellular Carcinoma.
Takai A, Dang H, Oishi N, Khatib S, Martin SP, Dominguez DA, Luo J, Bagni R, Wu X, Powell K, Ye QH, Jia HL, Qin LX, Chen J, Mitchell GA, Luo X, Thorgeirsson SS, Wang XW. Takai A, et al. Cancer Res. 2019 May 1;79(9):2379-2391. doi: 10.1158/0008-5472.CAN-18-3015. Epub 2019 Mar 12. Cancer Res. 2019. PMID: 30862714 Free PMC article.
PMPCB blockage suppressed EpCAM expression and Wnt/beta-catenin signaling via mitochondria-related reactive oxygen species production and FOXO activities, resulting in apoptosis and tumor suppression. These results indicate that a synthetic lethality screen is a viable str …
PMPCB blockage suppressed EpCAM expression and Wnt/beta-catenin signaling via mitochondria-related reactive oxygen species production …
Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood.
Vögtle FN, Brändl B, Larson A, Pendziwiat M, Friederich MW, White SM, Basinger A, Kücükköse C, Muhle H, Jähn JA, Keminer O, Helbig KL, Delto CF, Myketin L, Mossmann D, Burger N, Miyake N, Burnett A, van Baalen A, Lovell MA, Matsumoto N, Walsh M, Yu HC, Shinde DN, Stephani U, Van Hove JLK, Müller FJ, Helbig I. Vögtle FN, et al. Am J Hum Genet. 2018 Apr 5;102(4):557-573. doi: 10.1016/j.ajhg.2018.02.014. Epub 2018 Mar 22. Am J Hum Genet. 2018. PMID: 29576218 Free PMC article.
PMPCB encodes the catalytic subunit of the essential mitochondrial processing protease (MPP), which is required for maturation of the majority of mitochondrial precursor proteins. Mitochondria isolated from two fibroblast cell lines and induced pluripotent stem cells deriv …
PMPCB encodes the catalytic subunit of the essential mitochondrial processing protease (MPP), which is required for maturation of the …
Leigh syndrome with developmental regression and ataxia due to a novel splicing variant in the PMPCB gene.
Matthews E, Whittle EF, Khan F, McEntagart M, Carroll CJ. Matthews E, et al. J Hum Genet. 2024 Jun;69(6):283-285. doi: 10.1038/s10038-024-01226-9. Epub 2024 Feb 19. J Hum Genet. 2024. PMID: 38374165
Only five children with pathogenic PMPCB gene variants have been described and all carried missense variants. ...Three of the five died in childhood and none was older than age six when described. We report the first splice site variant in the PMPCB gene in a 39-yea …
Only five children with pathogenic PMPCB gene variants have been described and all carried missense variants. ...Three of the five di …
DIA mass spectrometry characterizes urinary proteomics in neonatal and adult donkeys.
Yu F, Chen Y, Liu B, Wang T, Ding Z, Yi Z, Zhu Y, Li J. Yu F, et al. Sci Rep. 2022 Dec 30;12(1):22590. doi: 10.1038/s41598-022-27245-0. Sci Rep. 2022. PMID: 36585464 Free PMC article.

Total 2179 urinary proteins were identified, and 411 proteins were differentially expressed (P < 0.05) between the two groups. 104 proteins were exclusively expressed in group N including alpha fetoprotein (AFP), peptidase-mitochondrial processing data unit (PMPCB), and

…

Total 2179 urinary proteins were identified, and 411 proteins were differentially expressed (P < 0.05) between the two groups. 104 protei

…
Acute lymphoblastic leukemia-derived dendritic cells express tumor associated antigens: PNPT1, PMPCB, RHAMM, BSG and ERCC1.
Luczynski W, Kowalczuk O, Stasiak-Barmuta A, Ilendo E, Krawczuk-Rybak M, Chyczewski L. Luczynski W, et al. Neoplasma. 2009;56(5):428-34. doi: 10.4149/neo_2009_05_428. Neoplasma. 2009. PMID: 19580345
The results of the study showed maintained expression and even up-regulation of some (PNPT1, PMPCB, HMMR/RHAMM, BSG and ERCC1) tumor associated antigens in CD40-activated leukemic cells. ...
The results of the study showed maintained expression and even up-regulation of some (PNPT1, PMPCB, HMMR/RHAMM, BSG and ERCC1) tumor …
Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA.
Key J, Torres-Odio S, Bach NC, Gispert S, Koepf G, Reichlmeir M, West AP, Prokisch H, Freisinger P, Newman WG, Shalev S, Sieber SA, Wittig I, Auburger G. Key J, et al. Cells. 2021 Nov 29;10(12):3354. doi: 10.3390/cells10123354. Cells. 2021. PMID: 34943861 Free PMC article.
Consistent accumulations in murine and human fibroblasts also affected multimerizing factors not known as ClpX interactors, namely, OAT, ASS1, ACADVL, STOM, PRDX3, PC, MUT, ALDH2, PMPCB, UQCRC2, and ACADSB, but the impact on downstream metabolites was marginal. ...
Consistent accumulations in murine and human fibroblasts also affected multimerizing factors not known as ClpX interactors, namely, OAT, ASS …
Integration of multi-omics technologies for molecular diagnosis in ataxia patients.
Audet S, Triassi V, Gelinas M, Legault-Cadieux N, Ferraro V, Duquette A, Tetreault M. Audet S, et al. Front Genet. 2024 Jan 4;14:1304711. doi: 10.3389/fgene.2023.1304711. eCollection 2023. Front Genet. 2024. PMID: 38239855 Free PMC article.
Results: Whole genome sequencing uncovered pathogenic variants in four genes (SPG7, ATXN2, ELOVL4, PMPCB). A missense and a nonsense variant, both previously reported as likely pathogenic, configured in trans in individual #1 (SPG7: c.2228T>C/p.I743T, c.1861C>T/p.Q62 …
Results: Whole genome sequencing uncovered pathogenic variants in four genes (SPG7, ATXN2, ELOVL4, PMPCB). A missense and a nonsense …
Novel IBA57 mutations in two chinese patients and literature review of multiple mitochondrial dysfunction syndrome.
Zhan F, Liu X, Ni R, Liu T, Cao Y, Wu J, Tian W, Luan X, Cao L. Zhan F, et al. Metab Brain Dis. 2022 Feb;37(2):311-317. doi: 10.1007/s11011-021-00856-8. Epub 2021 Oct 28. Metab Brain Dis. 2022. PMID: 34709542 Review.
So far, six types of MMDS have been identified based on different genotypes, which are caused by mutations in NFU1, BOLA3, IBA57, ISCA2, ISCA1 and PMPCB, respectively. IBA57 encodes a protein involved in the mitochondrial Fe/S cluster assembly process, which plays a vital …
So far, six types of MMDS have been identified based on different genotypes, which are caused by mutations in NFU1, BOLA3, IBA57, ISCA2, ISC …
Identification of 7 mitochondria-related genes as diagnostic biomarkers of MDD and their correlation with immune infiltration: New insights from bioinformatics analysis.
Liu X, Wu Y, Li M. Liu X, et al. J Affect Disord. 2024 Mar 15;349:86-100. doi: 10.1016/j.jad.2024.01.011. Epub 2024 Jan 8. J Affect Disord. 2024. PMID: 38199392
Finally, the variations in immune cell infiltration between different clusters, and the correlation between characteristic DeMRGs and immune cell infiltration were analyzed. RESULTS: Seven characteristic genes, including PMPCB, MRPS28, LYRM2, MGST1, COX20, PTPMT1, and STX1 …
Finally, the variations in immune cell infiltration between different clusters, and the correlation between characteristic DeMRGs and immune …
20 results