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Aggretin, a heterodimeric C-type lectin from Calloselasma rhodostoma (Malayan pit viper), stimulates platelets by binding to α2β1 integrin and glycoprotein Ib, activating Syk and phospholipase Cγ 2, but does not involve the glycoprotein VI/Fc receptor γ chain collagen receptor.
Navdaev A, Clemetson JM, Polgar J, Kehrel BE, Glauner M, Magnenat E, Wells TN, Clemetson KJ. Navdaev A, et al. Among authors: polgar j. J Biol Chem. 2001 Jun 15;276(24):20882-9. doi: 10.1074/jbc.M101585200. Epub 2001 Apr 3. J Biol Chem. 2001. PMID: 11287424 Free article.
Asp-49 is not an absolute prerequisite for the enzymic activity of low-M(r) phospholipases A2: purification, characterization and computer modelling of an enzymically active Ser-49 phospholipase A2, ecarpholin S, from the venom of Echis carinatus sochureki (saw-scaled viper).
Polgár J, Magnenat EM, Peitsch MC, Wells TN, Clemetson KJ. Polgár J, et al. Biochem J. 1996 Nov 1;319 ( Pt 3)(Pt 3):961-8. doi: 10.1042/bj3190961. Biochem J. 1996. PMID: 8921006 Free PMC article.
96 results