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Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties.
Nowikow C, Fuerst R, Kauderer M, Dank C, Schmid W, Hajduch M, Rehulka J, Gurska S, Mokshyna O, Polishchuk P, Zupkó I, Dzubak P, Rinner U. Nowikow C, et al. Among authors: polishchuk p. Bioorg Med Chem. 2019 Oct 1;27(19):115032. doi: 10.1016/j.bmc.2019.07.048. Epub 2019 Jul 29. Bioorg Med Chem. 2019. PMID: 31401010
Virtual screening, synthesis and biological evaluation of DNA intercalating antiviral agents.
Klimenko K, Lyakhov S, Shibinskaya M, Karpenko A, Marcou G, Horvath D, Zenkova M, Goncharova E, Amirkhanov R, Krysko A, Andronati S, Levandovskiy I, Polishchuk P, Kuz'min V, Varnek A. Klimenko K, et al. Among authors: polishchuk p. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3915-3919. doi: 10.1016/j.bmcl.2017.06.035. Epub 2017 Jun 13. Bioorg Med Chem Lett. 2017. PMID: 28666733 Free article.
Anticancer 5-arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones as tubulin inhibitors.
Rehulka J, Subtelna I, Kryshchyshyn-Dylevych A, Cherniienko A, Ivanova A, Matveieva M, Polishchuk P, Gurska S, Hajduch M, Zagrijtschuk O, Dzubak P, Lesyk R. Rehulka J, et al. Among authors: polishchuk p. Arch Pharm (Weinheim). 2022 Dec;355(12):e2200419. doi: 10.1002/ardp.202200419. Epub 2022 Sep 15. Arch Pharm (Weinheim). 2022. PMID: 36109178
Triazole-based estradiol dimers prepared via CuAAC from 17α-ethinyl estradiol with five-atom linkers causing G2/M arrest and tubulin inhibition.
Jurášek M, Řehulka J, Hrubá L, Ivanová A, Gurská S, Mokshyna O, Trousil P, Huml L, Polishchuk P, Hajdúch M, Drašar PB, Džubák P. Jurášek M, et al. Among authors: polishchuk p. Bioorg Chem. 2023 Feb;131:106334. doi: 10.1016/j.bioorg.2022.106334. Epub 2022 Dec 23. Bioorg Chem. 2023. PMID: 36592487 Free article.
Synthesis, biological evaluation, X-ray molecular structure and molecular docking studies of RGD mimetics containing 6-amino-2,3-dihydroisoindolin-1-one fragment as ligands of integrin αIIbβ₃.
Krysko AA, Samoylenko GV, Polishchuk PG, Fonari MS, Kravtsov VCh, Andronati SA, Kabanova TA, Lipkowski J, Khristova TM, Kuz'min VE, Kabanov VM, Krysko OL, Varnek AA. Krysko AA, et al. Bioorg Med Chem. 2013 Aug 1;21(15):4646-61. doi: 10.1016/j.bmc.2013.05.019. Epub 2013 May 22. Bioorg Med Chem. 2013. PMID: 23757209 Free article.
44 results