Reprogramming barriers in bovine cells nuclear transfer revealed by single-cell RNA-seq analysis.
Zhao L, Long C, Zhao G, Su J, Ren J, Sun W, Wang Z, Zhang J, Liu M, Hao C, Li H, Cao G, Bao S, Zuo Y, Li X.
Zhao L, et al.
J Cell Mol Med. 2022 Sep;26(18):4792-4804. doi: 10.1111/jcmm.17505. Epub 2022 Aug 15.
J Cell Mol Med. 2022.
PMID: 35971640
Free PMC article.
Particularly, SCNT 8-cell stage embryos showed failures in some gene activation, including ZSCAN4, and defects in protein association networks which cored as POLR2K, GRO1, and ANKRD1. Some important signalling pathways also showed incomplete activation at SCNT zygote to mo …
Particularly, SCNT 8-cell stage embryos showed failures in some gene activation, including ZSCAN4, and defects in protein association networ …