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Reprogramming barriers in bovine cells nuclear transfer revealed by single-cell RNA-seq analysis.
Zhao L, Long C, Zhao G, Su J, Ren J, Sun W, Wang Z, Zhang J, Liu M, Hao C, Li H, Cao G, Bao S, Zuo Y, Li X. Zhao L, et al. J Cell Mol Med. 2022 Sep;26(18):4792-4804. doi: 10.1111/jcmm.17505. Epub 2022 Aug 15. J Cell Mol Med. 2022. PMID: 35971640 Free PMC article.
Particularly, SCNT 8-cell stage embryos showed failures in some gene activation, including ZSCAN4, and defects in protein association networks which cored as POLR2K, GRO1, and ANKRD1. Some important signalling pathways also showed incomplete activation at SCNT zygote to mo …
Particularly, SCNT 8-cell stage embryos showed failures in some gene activation, including ZSCAN4, and defects in protein association networ …
Identification of key gene modules and hub genes of human mantle cell lymphoma by coexpression network analysis.
Guo D, Wang H, Sun L, Liu S, Du S, Qiao W, Wang W, Hou G, Zhang K, Li C, Teng Q. Guo D, et al. PeerJ. 2020 Mar 20;8:e8843. doi: 10.7717/peerj.8843. eCollection 2020. PeerJ. 2020. PMID: 32219041 Free PMC article.
The hub genes in the top weighted network were regarded as real hub genes (IL2RB, CD3D, RPL26L1, POLR2K, KIF11, CDC20, CCNB1, CCNA2, PUF60, SNRNP70, AKT1 and PRPF40A). ...
The hub genes in the top weighted network were regarded as real hub genes (IL2RB, CD3D, RPL26L1, POLR2K, KIF11, CDC20, CCNB1, CCNA2, …
An integrated co-expression network analysis reveals novel genetic biomarkers for immune cell infiltration in chronic kidney disease.
Xia J, Hou Y, Cai A, Xu Y, Yang W, Huang M, Mou S. Xia J, et al. Front Immunol. 2023 Feb 17;14:1129524. doi: 10.3389/fimmu.2023.1129524. eCollection 2023. Front Immunol. 2023. PMID: 36875100 Free PMC article.
RESULTS: In total, eight genes (CDCP1, CORO1C, DACH1, GSTA4, MAFB, TCF21, TGFBR3, and TGIF1) in kidney tissue and six genes (DDX17, KLF11, MAN1C1, POLR2K, ST14, and TRIM66) in PBMC were screened from co-expression network. ...
RESULTS: In total, eight genes (CDCP1, CORO1C, DACH1, GSTA4, MAFB, TCF21, TGFBR3, and TGIF1) in kidney tissue and six genes (DDX17, KLF11, M …
Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms: A bioinformatics study.
Zhang WJ, Yue KL, Wang JZ, Zhang Y. Zhang WJ, et al. World J Gastrointest Oncol. 2023 Dec 15;15(12):2150-2168. doi: 10.4251/wjgo.v15.i12.2150. World J Gastrointest Oncol. 2023. PMID: 38173437 Free PMC article.
In CRC, there were 1694 HSF4 methylation-related genes; 1468 of which displayed positive and 226 negative associations, and they were involved in regulating phenotypes such as immune, inflammatory, and metabolic reprogramming. EGFR, RELA, STAT3, FCGR3A, POLR2K, and AXIN1 a …
In CRC, there were 1694 HSF4 methylation-related genes; 1468 of which displayed positive and 226 negative associations, and they were involv …
An in-depth map of polyadenylation sites in cancer.
Lin Y, Li Z, Ozsolak F, Kim SW, Arango-Argoty G, Liu TT, Tenenbaum SA, Bailey T, Monaghan AP, Milos PM, John B. Lin Y, et al. Nucleic Acids Res. 2012 Sep 1;40(17):8460-71. doi: 10.1093/nar/gks637. Epub 2012 Jun 29. Nucleic Acids Res. 2012. PMID: 22753024 Free PMC article.
Candidate targets of alternative polyadenylation-mediated upregulation of short isoforms include POLR2K, and signaling cascades of cell-cell and cell-extracellular matrix contact, particularly involving regulators of Rho GTPases. ...
Candidate targets of alternative polyadenylation-mediated upregulation of short isoforms include POLR2K, and signaling cascades of ce …
Identification of miRNA biomarkers of pneumonia using RNA-sequencing and bioinformatics analysis.
Huang S, Feng C, Zhai YZ, Zhou X, Li B, Wang LL, Chen W, Lv FQ, Li TS. Huang S, et al. Exp Ther Med. 2017 Apr;13(4):1235-1244. doi: 10.3892/etm.2017.4151. Epub 2017 Feb 21. Exp Ther Med. 2017. PMID: 28413462 Free PMC article.
KALRN, Ras homolog family member A (RHOA), beta-catenin (CTNNB1), RNA polymerase II subunit K (POLR2K) and amyloid precursor protein (APP) were determined to encode crucial proteins in the PPI network constructed. KALRN was predicted to be a target of hsa-mir-200b, while R …
KALRN, Ras homolog family member A (RHOA), beta-catenin (CTNNB1), RNA polymerase II subunit K (POLR2K) and amyloid precursor protein …
Identification of key pathways, genes and immune cell infiltration in hypoxia of high-altitude acclimatization via meta-analysis and integrated bioinformatics analysis.
Li Q, Xu Z, Fang F, Shen Y, Lei H, Shen X. Li Q, et al. Front Genet. 2023 Mar 24;14:1055372. doi: 10.3389/fgene.2023.1055372. eCollection 2023. Front Genet. 2023. PMID: 37035734 Free PMC article.
DEGs were mostly enriched in biological processes and pathways associated with hypoxia acclimatization at high altitudes, according to both GO and KEGG enrichment analyses. ERH, VBP1, BINP3L, TOMM5, PSMA4, and POLR2K were identified by taking intersections of the DEGs betw …
DEGs were mostly enriched in biological processes and pathways associated with hypoxia acclimatization at high altitudes, according to both …
Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals.
Pang C, Sheng YC, Jiang P, Wei H, Ji LL. Pang C, et al. J Zhejiang Univ Sci B. 2015 Jul;16(7):602-10. doi: 10.1631/jzus.B1400346. J Zhejiang Univ Sci B. 2015. PMID: 26160718 Free PMC article.
Further, CGA increased the AP-induced decreased mRNA expression of peroxiredoxin (Prx) 1, 2, 3, 5, 6, epoxide hydrolase (Ephx) 2, and polymerase (RNA) II (DNA directed) polypeptide K (Polr2k), and nuclear factor erythroid-2-related factor 2 (Nrf2). In summary, CGA ameliora …
Further, CGA increased the AP-induced decreased mRNA expression of peroxiredoxin (Prx) 1, 2, 3, 5, 6, epoxide hydrolase (Ephx) 2, and polyme …
Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors.
Heidenblad M, Lindgren D, Jonson T, Liedberg F, Veerla S, Chebil G, Gudjonsson S, Borg A, Månsson W, Höglund M. Heidenblad M, et al. BMC Med Genomics. 2008 Jan 31;1:3. doi: 10.1186/1755-8794-1-3. BMC Med Genomics. 2008. PMID: 18237450 Free PMC article.
Amplification of the 8q22 segment was primarily associated with YWHAZ (14-3-3-zeta) and POLR2K over expression. The possible importance of the YWHA genes in the development of urothelial carcinomas was supported by another recurrent amplicon paralogous to 8q22, in 2p25, wh …
Amplification of the 8q22 segment was primarily associated with YWHAZ (14-3-3-zeta) and POLR2K over expression. The possible importan …
Pan-cancer integrated bioinformatic analysis of RNA polymerase subunits reveal RNA Pol I member CD3EAP regulates cell growth by modulating autophagy.
Bhandari N, Acharya D, Chatterjee A, Mandve L, Kumar P, Pratap S, Malakar P, Shukla SK. Bhandari N, et al. Cell Cycle. 2023 Sep;22(18):1986-2002. doi: 10.1080/15384101.2023.2265676. Epub 2023 Nov 23. Cell Cycle. 2023. PMID: 37795959
We discovered nine mutant RNAPS with a mutation frequency of more than 1% in at least one tumor type. POLR2K and POLR2H were found to be amplified and overexpressed, whereas POLR3D was deleted and downregulated. ...
We discovered nine mutant RNAPS with a mutation frequency of more than 1% in at least one tumor type. POLR2K and POLR2H were found to …
17 results