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Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation.
Hou Y, Zhang F, Lan J, Sun F, Li J, Li M, Song K, Wu X. Hou Y, et al. Drug Deliv. 2019 Dec;26(1):158-167. doi: 10.1080/10717544.2019.1568624. Drug Deliv. 2019. PMID: 30822157 Free PMC article.
The aim was to develop a nanocarrier based on polyoxyl 15 hydroxystearate (Kolliphor HS15, HS15) micelles for the solubility, stability, and ocular delivery of myricetin (Myr). ...
The aim was to develop a nanocarrier based on polyoxyl 15 hydroxystearate (Kolliphor HS15, HS15) micelles for the solub …
Safety of Polysorbate 80 in the Oncology Setting.
Schwartzberg LS, Navari RM. Schwartzberg LS, et al. Adv Ther. 2018 Jun;35(6):754-767. doi: 10.1007/s12325-018-0707-z. Epub 2018 May 23. Adv Ther. 2018. PMID: 29796927 Free PMC article. Review.
Recently, two polysorbate 80-free agents have been approved: intravenous rolapitant, which is a neurokinin 1 (NK-1) receptor antagonist formulated with the synthetic surfactant polyoxyl 15 hydroxystearate, and intravenous HTX-019, which is a novel NK-1 recept …
Recently, two polysorbate 80-free agents have been approved: intravenous rolapitant, which is a neurokinin 1 (NK-1) receptor antagonist form …
In-silico approach as a tool for selection of excipients for safer amphotericin B nanoformulations.
Todke PA, Devarajan PV. Todke PA, et al. J Control Release. 2022 Sep;349:756-764. doi: 10.1016/j.jconrel.2022.07.030. Epub 2022 Aug 1. J Control Release. 2022. PMID: 35905782
Excipients selected for the study included linear fatty acids from caprylic (C(8)) to stearic(C(18)) and the stearate based amphiphilic surfactants polyoxyl-15-hydroxystearate (PS15) and polyoxyl-40-stearate (PS40). ...
Excipients selected for the study included linear fatty acids from caprylic (C(8)) to stearic(C(18)) and the stearate based amphiphilic surf …
Febuxostat solubilization and stabilization approach using solid dispersion method: Synergistic effect of dicalcium phosphate dehydrate and chitosan.
Sohn JS, Choi JS. Sohn JS, et al. Int J Biol Macromol. 2023 Dec 31;253(Pt 5):127266. doi: 10.1016/j.ijbiomac.2023.127266. Epub 2023 Oct 5. Int J Biol Macromol. 2023. PMID: 37802445
The solubilization strategy of FBX is to develope an optimal FBX-SD formulation by selecting a solubilizer and carrier through the screening method. The final selected solubilizer, macrogol 15 hydroxystearate and polyoxyl 15 hydroxystearate (Kol …
The solubilization strategy of FBX is to develope an optimal FBX-SD formulation by selecting a solubilizer and carrier through the screening …
Case studies with new excipients: development, implementation and regulatory approval.
Koo OM, Varia SA. Koo OM, et al. Ther Deliv. 2011 Jul;2(7):949-56. doi: 10.4155/tde.11.62. Ther Deliv. 2011. PMID: 22833905 Review.
Therefore, the focus of this article will be on the FDA review process. Three case studies, polyoxyl 15 hydroxystearate, sulfobutyl ether cyclodextrin and silicified microcrystalline cellulose, are used to illustrate how new excipients are accepted and implem …
Therefore, the focus of this article will be on the FDA review process. Three case studies, polyoxyl 15 hydroxystearate …
Surfactant dependent toxicity of lipid nanocapsules in HaCaT cells.
Maupas C, Moulari B, Béduneau A, Lamprecht A, Pellequer Y. Maupas C, et al. Int J Pharm. 2011 Jun 15;411(1-2):136-41. doi: 10.1016/j.ijpharm.2011.03.056. Epub 2011 Apr 2. Int J Pharm. 2011. PMID: 21463666
LNC have been prepared using different non-ionic surfactants (Solutol() HS15: Polyoxyl 15 Hydroxystearate; Cremophor() EL: Polyoxyl 35 Castor Oil; Simulsol() 4000: Polyoxyl 40 Hydrogenated Castor Oil; Vitamin E TPGS(): alpha-tocopheryl poly(ethy …
LNC have been prepared using different non-ionic surfactants (Solutol() HS15: Polyoxyl 15 Hydroxystearate; Cremophor() …
Poly(lactic-co-glycolic) Acid/Solutol HS15-Based Nanoparticles for Docetaxel Delivery.
Cho HJ, Park JH, Kim DD, Yoon IS. Cho HJ, et al. J Nanosci Nanotechnol. 2016 Feb;16(2):1433-6. doi: 10.1166/jnn.2016.11918. J Nanosci Nanotechnol. 2016. PMID: 27433600
Poly(lactic- co-glycolic) acid (PLGA) is one of representative biocompatible and biodegradable polymers, and polyoxyl 15 hydroxystearate (Solutol HS15) is a nonionic solubilizer and emulsifying agent. ...
Poly(lactic- co-glycolic) acid (PLGA) is one of representative biocompatible and biodegradable polymers, and polyoxyl 15 hy …
Nasal delivery of an immunotherapeutic vaccine in thermosensitive hydrogel against allergic asthma.
Zhong Y, Su C, Wu S, Miao C, Wang B. Zhong Y, et al. Int Immunopharmacol. 2023 Mar;116:109718. doi: 10.1016/j.intimp.2023.109718. Epub 2023 Feb 2. Int Immunopharmacol. 2023. PMID: 36738673 Free article.
The hydrogel delivery system was formulated based on Poloxamer 407 (P407), Carbopol 974P NF, and Polyoxyl 15 hydroxystearate (Kolliphor HS15, HS15). It flowed freely at room temperature and rapidly formed a hydrogel in the nasal cavity once the temperature ro …
The hydrogel delivery system was formulated based on Poloxamer 407 (P407), Carbopol 974P NF, and Polyoxyl 15 hydroxystearat …
Simultaneous determination of kolliphor HS15 and miglyol 812 in microemulsion formulation by ultra-high performance liquid chromatography coupled with nano quantity analyte detector.
Zhang H, Wang Z, Liu O. Zhang H, et al. J Pharm Anal. 2016 Feb;6(1):11-17. doi: 10.1016/j.jpha.2015.11.004. Epub 2015 Nov 19. J Pharm Anal. 2016. PMID: 29403957 Free PMC article.
Good linearity (r>0.95) was obtained in the range of 27.6-1381.1 mug/mL for polyoxyl 15 hydroxystearate in kolliphor HS15, 0.8-202.0 mug/mL for caprylic acid triglyceride and 2.7-221.9 mug/mL for capric acid triglyceride in miglyol 812. ...Quantification l …
Good linearity (r>0.95) was obtained in the range of 27.6-1381.1 mug/mL for polyoxyl 15 hydroxystearate in kolliphor …
Solutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein.
Ding P, Chen Y, Cao G, Shen H, Ju J, Li W. Ding P, et al. Drug Des Devel Ther. 2019 Jun 7;13:1947-1956. doi: 10.2147/DDDT.S201453. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31239645 Free PMC article.
Purpose: We aimed to prepare two oral drug delivery systems consisting of polyoxyl 15 hydroxystearate (HS15) with pluronicF127 (F127) and HS15 with pluronicL61 (L61) to overcome the challenges of genistein's poor oral bioavailability. ...
Purpose: We aimed to prepare two oral drug delivery systems consisting of polyoxyl 15 hydroxystearate (HS15) with pluro …
21 results