Pongratz H - Search Results

1

Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors.

Sellmer A, Stangl H, Beyer M, Grünstein E, Leonhardt M, Pongratz H, Eichhorn E, Elz S, Striegl B, Jenei-Lanzl Z, Dove S, Straub RH, Krämer OH, Mahboobi S. Sellmer A, et al. Among authors: pongratz h. J Med Chem. 2018 Apr 26;61(8):3454-3477. doi: 10.1021/acs.jmedchem.7b01593. Epub 2018 Apr 6. J Med Chem. 2018. PMID: 29589441

2

Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents.

Mahboobi S, Pongratz H, Hufsky H, Hockemeyer J, Frieser M, Lyssenko A, Paper DH, Bürgermeister J, Böhmer FD, Fiebig HH, Burger AM, Baasner S, Beckers T. Mahboobi S, et al. Among authors: pongratz h. J Med Chem. 2001 Dec 20;44(26):4535-53. doi: 10.1021/jm010940+. J Med Chem. 2001. PMID: 11741473

3

Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.

Mahboobi S, Teller S, Pongratz H, Hufsky H, Sellmer A, Botzki A, Uecker A, Beckers T, Baasner S, Schächtele C, Uberall F, Kassack MU, Dove S, Böhmer FD. Mahboobi S, et al. Among authors: pongratz h. J Med Chem. 2002 Feb 28;45(5):1002-18. doi: 10.1021/jm010988n. J Med Chem. 2002. PMID: 11855980

4

2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors.

Beckers T, Reissmann T, Schmidt M, Burger AM, Fiebig HH, Vanhoefer U, Pongratz H, Hufsky H, Hockemeyer J, Frieser M, Mahboobi S. Beckers T, et al. Among authors: pongratz h. Cancer Res. 2002 Jun 1;62(11):3113-9. Cancer Res. 2002. PMID: 12036922

5

Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.

Mahboobi S, Uecker A, Sellmer A, Cénac C, Höcher H, Pongratz H, Eichhorn E, Hufsky H, Trümpler A, Sicker M, Heidel F, Fischer T, Stocking C, Elz S, Böhmer FD, Dove S. Mahboobi S, et al. Among authors: pongratz h. J Med Chem. 2006 Jun 1;49(11):3101-15. doi: 10.1021/jm058033i. J Med Chem. 2006. PMID: 16722630

6

2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.

Mahboobi S, Sellmer A, Höcher H, Garhammer C, Pongratz H, Maier T, Ciossek T, Beckers T. Mahboobi S, et al. Among authors: pongratz h. J Med Chem. 2007 Sep 6;50(18):4405-18. doi: 10.1021/jm0703136. Epub 2007 Aug 11. J Med Chem. 2007. PMID: 17691763

7

Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.

Mahboobi S, Dove S, Sellmer A, Winkler M, Eichhorn E, Pongratz H, Ciossek T, Baer T, Maier T, Beckers T. Mahboobi S, et al. Among authors: pongratz h. J Med Chem. 2009 Apr 23;52(8):2265-79. doi: 10.1021/jm800988r. J Med Chem. 2009. PMID: 19301902

8

Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.

Mahboobi S, Sellmer A, Winkler M, Eichhorn E, Pongratz H, Ciossek T, Baer T, Maier T, Beckers T. Mahboobi S, et al. Among authors: pongratz h. J Med Chem. 2010 Dec 23;53(24):8546-55. doi: 10.1021/jm100665z. Epub 2010 Nov 16. J Med Chem. 2010. PMID: 21080629

9

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.

Beckers T, Sellmer A, Eichhorn E, Pongratz H, Schächtele C, Totzke F, Kelter G, Krumbach R, Fiebig HH, Böhmer FD, Mahboobi S. Beckers T, et al. Among authors: pongratz h. Bioorg Med Chem. 2012 Jan 1;20(1):125-36. doi: 10.1016/j.bmc.2011.11.023. Epub 2011 Nov 20. Bioorg Med Chem. 2012. PMID: 22169601

10

A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.

Sellmer A, Pilsl B, Beyer M, Pongratz H, Wirth L, Elz S, Dove S, Henninger SJ, Spiekermann K, Polzer H, Klaeger S, Kuster B, Böhmer FD, Fiebig HH, Krämer OH, Mahboobi S. Sellmer A, et al. Among authors: pongratz h. Eur J Med Chem. 2020 May 1;193:112232. doi: 10.1016/j.ejmech.2020.112232. Epub 2020 Mar 13. Eur J Med Chem. 2020. PMID: 32199135

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