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Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.
Proc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54. doi: 10.1073/pnas.0702854104. Epub 2007 May 14.
Proc Natl Acad Sci U S A. 2007.
PMID: 17502596
Free PMC article.
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.
Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M.
Chen Q, et al. Among authors: pooput c.
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9. doi: 10.1073/pnas.0804226105. Epub 2008 Aug 4.
Proc Natl Acad Sci U S A. 2008.
PMID: 18678913
Free PMC article.
Clinical Trial.
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Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines.
Pooput C, Rosemond E, Karpiak J, Deflorian F, Vilar S, Costanzi S, Wess J, Kirk KL.
Pooput C, et al.
Bioorg Med Chem. 2009 Dec 1;17(23):7987-92. doi: 10.1016/j.bmc.2009.10.015. Epub 2009 Oct 13.
Bioorg Med Chem. 2009.
PMID: 19857969
Free PMC article.
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Evidence that histidine protonation of receptor-bound anthrax protective antigen is a trigger for pore formation.
Wimalasena DS, Janowiak BE, Lovell S, Miyagi M, Sun J, Zhou H, Hajduch J, Pooput C, Kirk KL, Battaile KP, Bann JG.
Wimalasena DS, et al. Among authors: pooput c.
Biochemistry. 2010 Aug 24;49(33):6973-83. doi: 10.1021/bi100647z.
Biochemistry. 2010.
PMID: 20672855
Free PMC article.
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Analysis of chloroquine resistance transporter (CRT) isoforms and orthologues in S. cerevisiae yeast.
Baro NK, Pooput C, Roepe PD.
Baro NK, et al. Among authors: pooput c.
Biochemistry. 2011 Aug 9;50(31):6701-10. doi: 10.1021/bi200922g. Epub 2011 Jul 19.
Biochemistry. 2011.
PMID: 21744797
Free PMC article.
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Nucleophilic perfluoroalkylation of aldehydes, ketones, imines, disulfides, and diselenides.
Pooput C, Dolbier WR Jr, Médebielle M.
Pooput C, et al.
J Org Chem. 2006 Apr 28;71(9):3564-8. doi: 10.1021/jo060250j.
J Org Chem. 2006.
PMID: 16626142
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A new and efficient method for the synthesis of trifluoromethylthio- and selenoethers.
Pooput C, Medebielle M, Dolbier WR Jr.
Pooput C, et al.
Org Lett. 2004 Jan 22;6(2):301-3. doi: 10.1021/ol036303q.
Org Lett. 2004.
PMID: 14723553
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