Poruchynsky M - Search Results

1

Mesothelin-targeted immunotoxin RG7787 has synergistic anti-tumor activity when combined with taxanes.

Kolyvas E, Rudloff M, Poruchynsky M, Landsman R, Hollevoet K, Venzon D, Alewine C. Kolyvas E, et al. Among authors: poruchynsky m. Oncotarget. 2017 Feb 7;8(6):9189-9199. doi: 10.18632/oncotarget.13984. Oncotarget. 2017. PMID: 27999204 Free PMC article.

2

Combinations of paclitaxel and vinblastine and their effects on tubulin polymerization and cellular cytotoxicity: characterization of a synergistic schedule.

Giannakakou P, Villalba L, Li H, Poruchynsky M, Fojo T. Giannakakou P, et al. Among authors: poruchynsky m. Int J Cancer. 1998 Jan 5;75(1):57-63. doi: 10.1002/(sici)1097-0215(19980105)75:1<57::aid-ijc10>3.0.co;2-a. Int J Cancer. 1998. PMID: 9426691 Free article.

3

Evidence for microtubule target engagement in tumors of patients receiving ixabepilone.

Zhuang SH, Hung YE, Hung L, Robey RW, Sackett DL, Linehan WM, Bates SE, Fojo T, Poruchynsky MS. Zhuang SH, et al. Among authors: poruchynsky ms. Clin Cancer Res. 2007 Dec 15;13(24):7480-6. doi: 10.1158/1078-0432.CCR-06-2883. Clin Cancer Res. 2007. PMID: 18094432 Clinical Trial.

4

Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: a possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition.

Poruchynsky MS, Sackett DL, Robey RW, Ward Y, Annunziata C, Fojo T. Poruchynsky MS, et al. Cell Cycle. 2008 Apr 1;7(7):940-9. doi: 10.4161/cc.7.7.5625. Epub 2008 Jan 17. Cell Cycle. 2008. PMID: 18414063 Free PMC article.

5

A phase II clinical trial of ixabepilone (Ixempra; BMS-247550; NSC 710428), an epothilone B analog, in patients with metastatic renal cell carcinoma.

Huang H, Menefee M, Edgerly M, Zhuang S, Kotz H, Poruchynsky M, Huff LM, Bates S, Fojo T. Huang H, et al. Among authors: poruchynsky m. Clin Cancer Res. 2010 Mar 1;16(5):1634-41. doi: 10.1158/1078-0432.CCR-09-0379. Epub 2010 Feb 23. Clin Cancer Res. 2010. PMID: 20179242 Free PMC article. Clinical Trial.

6

Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer.

Low JA, Wedam SB, Lee JJ, Berman AW, Brufsky A, Yang SX, Poruchynsky MS, Steinberg SM, Mannan N, Fojo T, Swain SM. Low JA, et al. Among authors: poruchynsky ms. J Clin Oncol. 2005 Apr 20;23(12):2726-34. doi: 10.1200/JCO.2005.10.024. J Clin Oncol. 2005. PMID: 15837987 Clinical Trial.

7

Bcl-xL is phosphorylated in malignant cells following microtubule disruption.

Poruchynsky MS, Wang EE, Rudin CM, Blagosklonny MV, Fojo T. Poruchynsky MS, et al. Cancer Res. 1998 Aug 1;58(15):3331-8. Cancer Res. 1998. PMID: 9699663

8

Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism.

Poruchynsky MS, Giannakakou P, Ward Y, Bulinski JC, Telford WG, Robey RW, Fojo T. Poruchynsky MS, et al. Biochem Pharmacol. 2001 Dec 1;62(11):1469-80. doi: 10.1016/s0006-2952(01)00804-8. Biochem Pharmacol. 2001. PMID: 11728383

9

Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma.

Burotto M, Edgerly M, Poruchynsky M, Velarde M, Wilkerson J, Kotz H, Bates S, Balasubramaniam S, Fojo T. Burotto M, et al. Among authors: poruchynsky m. Oncologist. 2015 Jul;20(7):725-6. doi: 10.1634/theoncologist.2015-0104. Epub 2015 Jun 3. Oncologist. 2015. PMID: 26040622 Free PMC article. Clinical Trial.

10

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins.

Poruchynsky MS, Komlodi-Pasztor E, Trostel S, Wilkerson J, Regairaz M, Pommier Y, Zhang X, Kumar Maity T, Robey R, Burotto M, Sackett D, Guha U, Fojo AT. Poruchynsky MS, et al. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1571-6. doi: 10.1073/pnas.1416418112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605897 Free PMC article.

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