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Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.
de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van Nieuwkoop S, Bestebroer TM, van den Hoogen BG, Neyts J, Snijder EJ. de Wilde AH, et al. Among authors: posthuma cc. Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84. doi: 10.1128/AAC.03011-14. Epub 2014 May 19. Antimicrob Agents Chemother. 2014. PMID: 24841269 Free PMC article.
MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment.
de Wilde AH, Raj VS, Oudshoorn D, Bestebroer TM, van Nieuwkoop S, Limpens RWAL, Posthuma CC, van der Meer Y, Bárcena M, Haagmans BL, Snijder EJ, van den Hoogen BG. de Wilde AH, et al. Among authors: posthuma cc. J Gen Virol. 2013 Aug;94(Pt 8):1749-1760. doi: 10.1099/vir.0.052910-0. Epub 2013 Apr 25. J Gen Virol. 2013. PMID: 23620378 Free PMC article.
Cyclophilins and cyclophilin inhibitors in nidovirus replication.
de Wilde AH, Pham U, Posthuma CC, Snijder EJ. de Wilde AH, et al. Among authors: posthuma cc. Virology. 2018 Sep;522:46-55. doi: 10.1016/j.virol.2018.06.011. Epub 2018 Jul 12. Virology. 2018. PMID: 30014857 Free PMC article. Review.
33 results