Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 4
1994 2
1995 2
1996 6
1997 7
1998 11
1999 7
2000 2
2001 7
2002 12
2003 8
2004 11
2005 11
2006 7
2007 4
2008 9
2009 10
2010 7
2011 10
2012 16
2013 8
2014 11
2015 15
2016 11
2017 9
2018 9
2019 10
2020 19
2021 18
2022 9
2023 7
2024 5

Text availability

Article attribute

Article type

Publication date

Search Results

262 results

Results by year

Filters applied: . Clear all
Page 1
Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage-myofibroblast transition.
Tang PM, Zhang YY, Xiao J, Tang PC, Chung JY, Li J, Xue VW, Huang XR, Chong CC, Ng CF, Lee TL, To KF, Nikolic-Paterson DJ, Lan HY. Tang PM, et al. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20741-20752. doi: 10.1073/pnas.1917663117. Epub 2020 Aug 11. Proc Natl Acad Sci U S A. 2020. PMID: 32788346 Free PMC article.
Mechanistically, chromatin immunoprecipitation (ChIP) assay identified that Pou4f1 is a Smad3 target and the key downstream regulator of MMT, while microarray analysis defined a Pou4f1-dependent fibrogenic gene network for promoting TGF-beta1/Smad3-driven MMT in BMD …
Mechanistically, chromatin immunoprecipitation (ChIP) assay identified that Pou4f1 is a Smad3 target and the key downstream regulator …
Pou4f1-Tbr1 transcriptional cascade controls the formation of Jam2-expressing retinal ganglion cells.
Kiyama T, Altay HY, Badea TC, Mao CA. Kiyama T, et al. Front Ophthalmol (Lausanne). 2023;3:1175568. doi: 10.3389/fopht.2023.1175568. Epub 2023 May 18. Front Ophthalmol (Lausanne). 2023. PMID: 38469155 Free PMC article.
We showed that Pou4f1 is required for the expression of Tbr1 and Jam2, indicating Pou4f1 as a direct upstream regulator of Tbr1 and Jam2. ...Together, these data revealed a Pou4f1-Tbr1-Jam2 genetic hierarchy as a critical pathway in the formation of J-RGC sub …
We showed that Pou4f1 is required for the expression of Tbr1 and Jam2, indicating Pou4f1 as a direct upstream regulator of Tbr …
POU4F1 promotes the resistance of melanoma to BRAF inhibitors through MEK/ERK pathway activation and MITF up-regulation.
Liu L, Yue Q, Ma J, Liu Y, Zhao T, Guo W, Zhu G, Guo S, Wang S, Gao T, Li C, Shi Q. Liu L, et al. Cell Death Dis. 2020 Jun 12;11(6):451. doi: 10.1038/s41419-020-2662-2. Cell Death Dis. 2020. PMID: 32532957 Free PMC article.
However, whether POU4F1 contributes to the resistance of melanoma to BRAFi remains poorly understood. ...Our study supports that POU4F1 is a potential combined therapeutic target with BRAFi therapy for melanoma....
However, whether POU4F1 contributes to the resistance of melanoma to BRAFi remains poorly understood. ...Our study supports that P …
POU4F1 confers trastuzumab resistance in HER2-positive breast cancer through regulating ERK1/2 signaling pathway.
Wu D, Jia HY, Wei N, Li SJ. Wu D, et al. Biochem Biophys Res Commun. 2020 Dec 10;533(3):533-539. doi: 10.1016/j.bbrc.2020.09.003. Epub 2020 Sep 26. Biochem Biophys Res Commun. 2020. PMID: 32988584
Higher POU4F1 was also detected in HER2-positive breast cancer cells with TRA resistance than that of the parental ones. Poor prognosis was detected in breast cancer patients with high POU4F1 expression. Under TRA treatment, POU4F1 knockdown significantly red …
Higher POU4F1 was also detected in HER2-positive breast cancer cells with TRA resistance than that of the parental ones. Poor prognos …
Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor.
Webb BD, Evans A, Naidich TP, M Bird L, Parikh S, Fernandez Garcia M, Henderson LB, Millan F, Si Y, Brennand KJ, Hung P, Rucker JC, Wheeler PG, Schadt EE. Webb BD, et al. Hum Mutat. 2021 Jun;42(6):685-693. doi: 10.1002/humu.24201. Epub 2021 Apr 15. Hum Mutat. 2021. PMID: 33783914 Free PMC article.
POU4F1 is expressed in the developing nervous system, and mice homozygous for null alleles of Pou4f1 exhibit uncoordinated movements with newborns being unable to successfully right themselves to feed. ...These findings suggest that heterozygous, loss-of-function va …
POU4F1 is expressed in the developing nervous system, and mice homozygous for null alleles of Pou4f1 exhibit uncoordinated mov …
Pou4f1 Defines a Subgroup of Type I Spiral Ganglion Neurons and Is Necessary for Normal Inner Hair Cell Presynaptic Ca(2+) Signaling.
Sherrill HE, Jean P, Driver EC, Sanders TR, Fitzgerald TS, Moser T, Kelley MW. Sherrill HE, et al. J Neurosci. 2019 Jul 3;39(27):5284-5298. doi: 10.1523/JNEUROSCI.2728-18.2019. Epub 2019 May 13. J Neurosci. 2019. PMID: 31085606 Free PMC article.
Conditional deletion of Pou4f1 in SGNs beginning in mice at embryonic day 13 rescues the early path-finding and apoptotic phenotypes reported for germline deletion of Pou4f1, resulting in a phenotypically normal development of SGN patterning. However, conditional de …
Conditional deletion of Pou4f1 in SGNs beginning in mice at embryonic day 13 rescues the early path-finding and apoptotic phenotypes …
Activation of Bivalent Gene POU4F1 Promotes and Maintains Basal-like Breast Cancer.
Zhang J, Miao N, Lao L, Deng W, Wang J, Zhu X, Huang Y, Lin H, Zeng W, Zhang W, Tan L, Yuan X, Zeng X, Zhu J, Chen X, Song E, Yang L, Nie Y, Huang D. Zhang J, et al. Adv Sci (Weinh). 2024 Mar 16:e2307660. doi: 10.1002/advs.202307660. Online ahead of print. Adv Sci (Weinh). 2024. PMID: 38491910
POU4F1 is necessary for the tumor growth and malignant phenotypes of BLBC through regulating G1/S transition by direct binding at the promoter of CDK2 and CCND1. ...Knocking out POU4F1 in BLBC cells reactivates functional ERalpha expression, rendering BLBC sensitive …
POU4F1 is necessary for the tumor growth and malignant phenotypes of BLBC through regulating G1/S transition by direct binding at the …
Xihuang pill facilitates glioma cell pyroptosis via the POU4F1/STAT3 axis.
Tang N, Zhu Y, Yu J. Tang N, et al. Funct Integr Genomics. 2023 Nov 14;23(4):334. doi: 10.1007/s10142-023-01263-1. Funct Integr Genomics. 2023. PMID: 37962640
Immunofluorescence showed NLRP3 expression in glioma cells and western blotting measured the levels of POU4F1, STAT3, NLRP3, ASC, cleaved caspase-1, and IL-1beta. The binding of POU4F1 to STAT3 was verified. ...However, POU4F1 overexpression or STAT3 silencin …
Immunofluorescence showed NLRP3 expression in glioma cells and western blotting measured the levels of POU4F1, STAT3, NLRP3, ASC, cle …
Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.
Huang L, Hu F, Xie X, Harder J, Fernandes K, Zeng XY, Libby R, Gan L. Huang L, et al. PLoS One. 2014 Apr 15;9(4):e94173. doi: 10.1371/journal.pone.0094173. eCollection 2014. PLoS One. 2014. PMID: 24736625 Free PMC article.
METHODS: Conditional alleles of Pou4f1 and Pou4f2 were generated (Pou4f1loxP and Pou4f2loxP respectively) for the removal of Pou4f1 and Pou4f2 in adult retinas. ...RESULTS: Pou4f1 and Pou4f2 were ablated two weeks after tamoxifen treatment. ...
METHODS: Conditional alleles of Pou4f1 and Pou4f2 were generated (Pou4f1loxP and Pou4f2loxP respectively) for the removal of Pou4f …
Brn3a/Pou4f1 Functions as a Tumor Suppressor by Targeting c-MET/STAT3 Signaling in Thyroid Cancer.
Jung SN, Kang YE, Lee GH, Liu L, Oh C, Jin YL, Lim MA, Lee K, Oh T, Won HR, Chang JW, Koo BS. Jung SN, et al. J Clin Endocrinol Metab. 2020 Sep 1;105(9):dgaa316. doi: 10.1210/clinem/dgaa316. J Clin Endocrinol Metab. 2020. PMID: 32474599
BACKGROUND: Brn3a/Pou4f1 is a class IV POU domain-containing transcription factor and has been found to be expressed in a variety of cancers. ...
BACKGROUND: Brn3a/Pou4f1 is a class IV POU domain-containing transcription factor and has been found to be expressed in a variety of …
262 results