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1979 1
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2002 3
2003 9
2004 6
2005 3
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2007 3
2008 5
2009 2
2010 5
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454 results

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Page 1
A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.
Kodama M, Oshikawa K, Shimizu H, Yoshioka S, Takahashi M, Izumi Y, Bamba T, Tateishi C, Tomonaga T, Matsumoto M, Nakayama KI. Kodama M, et al. Nat Commun. 2020 Mar 17;11(1):1320. doi: 10.1038/s41467-020-15136-9. Nat Commun. 2020. PMID: 32184390 Free PMC article.
The fate of glutamine nitrogen is shifted from the anaplerotic pathway into the TCA cycle to nucleotide biosynthesis, with this shift being controlled by glutaminase (GLS1) and phosphoribosyl pyrophosphate amidotransferase (PPAT). Interventions to reduce the PPAT/GL …
The fate of glutamine nitrogen is shifted from the anaplerotic pathway into the TCA cycle to nucleotide biosynthesis, with this shift being …
SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT.
Huo FC, Xie M, Zhu ZM, Zheng JN, Pei DS. Huo FC, et al. Genomics. 2022 Jul;114(4):110424. doi: 10.1016/j.ygeno.2022.110424. Epub 2022 Jul 5. Genomics. 2022. PMID: 35798250 Free article.
SHMT2-catalyzed serine/glycine conversion regulated PPAT expression in an m6A-IGF2BP2-dependent manner. SHMT2 promoted RCC cell proliferation by upregulating PPAT expression. CONCLUSIONS: SHMT2 promotes RCC tumorigenesis by increasing PPAT expression. Thus, S …
SHMT2-catalyzed serine/glycine conversion regulated PPAT expression in an m6A-IGF2BP2-dependent manner. SHMT2 promoted RCC cell proli …
Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine.
Passos GR, de Oliveira MG, Ghezzi AC, Mello GC, Levi D'Ancona CA, Teixeira SA, Muscará MN, Grespan Bottoli CB, Vilela de Melo L, de Oliveira E, Antunes E, Mónica FZ. Passos GR, et al. Front Pharmacol. 2023 Jul 10;14:1145860. doi: 10.3389/fphar.2023.1145860. eCollection 2023. Front Pharmacol. 2023. PMID: 37492091 Free PMC article.
Background: The prostate gland is surrounded by periprostatic adipose tissue (PPAT) that can release mediators that interfere in prostate function. ...A trend toward an increase in the levels of NOX was observed after 60 min. PPAT supernatant from obese mice signifi …
Background: The prostate gland is surrounded by periprostatic adipose tissue (PPAT) that can release mediators that interfere in pros …
Frameshift mutations of OGDH, PPAT and PCCA genes in gastric and colorectal cancers.
Jo YS, Oh HR, Kim MS, Yoo NJ, Lee SH. Jo YS, et al. Neoplasma. 2016;63(5):681-6. doi: 10.4149/neo_2016_504. Neoplasma. 2016. PMID: 27468871
The aim of this study was to identify whether somatic mutations in OGDH, PPAT and PCCA genes known to be involved in amino acid or nucleotide metabolism are mutated in gastric cancer (GC) and colorectal cancer (CRC). By public database search, we identified that OGDH, P …
The aim of this study was to identify whether somatic mutations in OGDH, PPAT and PCCA genes known to be involved in amino acid or nu …
In Silico Structure Modeling and Molecular Docking Analysis of Phosphoribosyl Pyrophosphate Amidotransferase (PPAT) with Antifolate Inhibitors.
Bibi N, Parveen Z, Nawaz MS, Kamal MA. Bibi N, et al. Curr Cancer Drug Targets. 2019;19(5):408-416. doi: 10.2174/1568009619666181127115015. Curr Cancer Drug Targets. 2019. PMID: 30479216
Hence PPAT, the key regulatory spot in De novo purine nucleotide biosynthesis, is an attractive and credible drug target for leukemia and other cancer therapeutics. OBJECTIVE: In the present study, detailed computational analysis has been performed for PPAT protein, …
Hence PPAT, the key regulatory spot in De novo purine nucleotide biosynthesis, is an attractive and credible drug target for leukemia …
Periprostatic Adipose Tissue Microenvironment: Metabolic and Hormonal Pathways During Prostate Cancer Progression.
Sacca PA, Calvo JC. Sacca PA, et al. Front Endocrinol (Lausanne). 2022 Apr 13;13:863027. doi: 10.3389/fendo.2022.863027. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35498409 Free PMC article. Review.
The PPAT secretome of patients with PCa-T3 stage (PPAT-T3) has a metabolic profile enriched in several pathways related to energy production, indicating a greater energy requirement by the tumor, when compared to that of patients in the PCa-T2 stage (PPAT-T2) …
The PPAT secretome of patients with PCa-T3 stage (PPAT-T3) has a metabolic profile enriched in several pathways related to ene …
Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J. de Jonge BL, et al. Antimicrob Agents Chemother. 2013 Dec;57(12):6005-15. doi: 10.1128/AAC.01661-13. Epub 2013 Sep 16. Antimicrob Agents Chemother. 2013. PMID: 24041904 Free PMC article.
Inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. ...Mode-of-action studies, using generation of resistant mutants with targeted sequencing as well as constructs that overex …
Inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca c …
The lipidomic profile of the tumoral periprostatic adipose tissue reveals alterations in tumor cell's metabolic crosstalk.
Altuna-Coy A, Ruiz-Plazas X, Sánchez-Martin S, Ascaso-Til H, Prados-Saavedra M, Alves-Santiago M, Bernal-Escoté X, Segarra-Tomás J, R Chacón M. Altuna-Coy A, et al. BMC Med. 2022 Aug 18;20(1):255. doi: 10.1186/s12916-022-02457-3. BMC Med. 2022. PMID: 35978404 Free PMC article.
BACKGROUND: Periprostatic adipose tissue (PPAT) plays a role in prostate cancer (PCa) progression. PPAT lipidomic composition study may allow us to understand the tumor metabolic microenvironment and provide new stratification factors. ...Metabolic crosstalk between …
BACKGROUND: Periprostatic adipose tissue (PPAT) plays a role in prostate cancer (PCa) progression. PPAT lipidomic composition …
The Role of Purine Metabolism-Related Genes PPAT and IMPDH1 in the Carcinogenesis of Intrahepatic Cholangiocarcinoma Based on Metabonomic and Bioinformatic Analyses.
Liu CJ, Ma ZZ, Gong WZ, Mao XH, Wen HQ, Wang XH. Liu CJ, et al. J Oncol. 2023 Jan 20;2023:5141836. doi: 10.1155/2023/5141836. eCollection 2023. J Oncol. 2023. PMID: 36711025 Free PMC article.
TCGA database samples were collected, and the correlation between purine metabolism-related genes and ICC clinical features was analyzed using R language to obtain the differential genes including PPAT, PFAS, ATIC, and IMPDH2. High PPAT expression was associated wit …
TCGA database samples were collected, and the correlation between purine metabolism-related genes and ICC clinical features was analyzed usi …
454 results