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PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome.
Mu L, Ye Z, Hu J, Zhang Y, Chen K, Sun H, Li R, Mao W, Long X, Zhang C, Lai Y, Liu J, Zhao Y, Qiao J. Mu L, et al. EBioMedicine. 2023 Mar;89:104492. doi: 10.1016/j.ebiom.2023.104492. Epub 2023 Feb 28. EBioMedicine. 2023. PMID: 36863088 Free PMC article.
The function of the gene coding the protein phosphatase Mg(2+)/Mn(2+)-dependent 1K (PPM1K) was further explored by using Ppm1k-deficient mouse model and PPM1K down-regulated human ovarian granulosa cells. ...INTERPRETATION: Ppm1k deficiency-impaired BC …
The function of the gene coding the protein phosphatase Mg(2+)/Mn(2+)-dependent 1K (PPM1K) was further explored by using Ppm1k …
PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons.
Li T, Zhao L, Li Y, Dang M, Lu J, Lu Z, Huang Q, Yang Y, Feng Y, Wang X, Jian Y, Wang H, Guo Y, Zhang L, Jiang Y, Fan S, Wu S, Fan H, Kuang F, Zhang G. Li T, et al. Cell Death Dis. 2023 Sep 26;14(9):634. doi: 10.1038/s41419-023-06135-x. Cell Death Dis. 2023. PMID: 37752100 Free PMC article.
Here, we aim to investigate the mechanism of protein phosphatase Mg(2+)/Mn(2+) dependent 1 K (PPM1K) mediates metabolic disorder of branched-chain amino acids (BCAA) by promoting fatty acid oxidation led to ferroptosis after cerebral I/R injury. ...Additionally, the level …
Here, we aim to investigate the mechanism of protein phosphatase Mg(2+)/Mn(2+) dependent 1 K (PPM1K) mediates metabolic disorder of b …
The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.
White PJ, McGarrah RW, Grimsrud PA, Tso SC, Yang WH, Haldeman JM, Grenier-Larouche T, An J, Lapworth AL, Astapova I, Hannou SA, George T, Arlotto M, Olson LB, Lai M, Zhang GF, Ilkayeva O, Herman MA, Wynn RM, Chuang DT, Newgard CB. White PJ, et al. Cell Metab. 2018 Jun 5;27(6):1281-1293.e7. doi: 10.1016/j.cmet.2018.04.015. Epub 2018 May 17. Cell Metab. 2018. PMID: 29779826 Free PMC article.
These studies identify BDK and PPM1K as a ChREBP-regulated node that integrates BCAA and lipid metabolism. Moreover, manipulation of the BDK:PPM1K ratio relieves key metabolic disease phenotypes in a genetic model of severe obesity....
These studies identify BDK and PPM1K as a ChREBP-regulated node that integrates BCAA and lipid metabolism. Moreover, manipulation of …
PPM1K defects cause mild maple syrup urine disease: The second case in the literature.
Ozcelik F, Arslan S, Ozguc Caliskan B, Kardas F, Ozkul Y, Dundar M. Ozcelik F, et al. Am J Med Genet A. 2023 May;191(5):1360-1365. doi: 10.1002/ajmg.a.63129. Epub 2023 Jan 27. Am J Med Genet A. 2023. PMID: 36706222
Biallelic pathogenic variants in BCKDHA, BCKDHB, or DBT are characteristic of MSUD. In addition, a patient with a PPM1K defect was previously reported. PPM1K dephosphorylates and activates the enzyme complex. We report a patient with MSUD with mild findings and elev …
Biallelic pathogenic variants in BCKDHA, BCKDHB, or DBT are characteristic of MSUD. In addition, a patient with a PPM1K defect was pr …
Branched-chain amino acids in metabolic signalling and insulin resistance.
Lynch CJ, Adams SH. Lynch CJ, et al. Nat Rev Endocrinol. 2014 Dec;10(12):723-36. doi: 10.1038/nrendo.2014.171. Epub 2014 Oct 7. Nat Rev Endocrinol. 2014. PMID: 25287287 Free PMC article. Review.
Research on the role of individual and model-dependent differences in BCAA metabolism is needed, as several genes (BCKDHA, PPM1K, IVD and KLF15) have been designated as candidate genes for obesity and/or T2DM in humans, and distinct phenotypes of tissue-specific branched c …
Research on the role of individual and model-dependent differences in BCAA metabolism is needed, as several genes (BCKDHA, PPM1K, IVD …
Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease.
Hu W, Liu Z, Yu W, Wen S, Wang X, Qi X, Hao H, Lu Y, Li J, Li S, Zhou H. Hu W, et al. Ann Med. 2021 Dec;53(1):1316-1326. doi: 10.1080/07853890.2021.1965204. Ann Med. 2021. PMID: 34382495 Free PMC article.
OBJECTIVE: This study aimed to investigate the effects of PPM1K rs1440581 and rs7678928 single nucleotide polymorphisms (SNPs) on the serum branched-chain amino acids (BCAAs) levels and cardiovascular disease (CVD) risk. ...TRIAL REGISTRATION: Diabetes Prevention Programme …
OBJECTIVE: This study aimed to investigate the effects of PPM1K rs1440581 and rs7678928 single nucleotide polymorphisms (SNPs) on the …
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors.
Kamada R, Kudoh F, Ito S, Tani I, Janairo JIB, Omichinski JG, Sakaguchi K. Kamada R, et al. Pharmacol Ther. 2020 Nov;215:107622. doi: 10.1016/j.pharmthera.2020.107622. Epub 2020 Jul 7. Pharmacol Ther. 2020. PMID: 32650009 Review.
In mammals, there are 20 isoforms of PPM phosphatases: PPM1A, PPM1B, PPM1D, PPM1E, PPM1F, PPM1G, PPM1H, PPM1J, PPM1K, PPM1L, PPM1M, PPM1N, ILKAP, PDP1, PDP2, PHLPP1, PHLPP2, PP2D1, PPTC7, and TAB1, whereas there are only 8 in yeast. Phylogenetic analysis of the DNA sequenc …
In mammals, there are 20 isoforms of PPM phosphatases: PPM1A, PPM1B, PPM1D, PPM1E, PPM1F, PPM1G, PPM1H, PPM1J, PPM1K, PPM1L, PPM1M, P …
PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.
Liu X, Zhang F, Zhang Y, Li X, Chen C, Zhou M, Yu Z, Liu Y, Zhao Y, Hao X, Tang Y, Zhu L, Liu L, Xie L, Gu H, Shao H, Xia F, Yin C, Tao M, Xie J, Zhang CC, Yang Y, Sun H, Chen GQ, Zheng J. Liu X, et al. Cell Rep. 2018 May 1;23(5):1461-1475. doi: 10.1016/j.celrep.2018.03.140. Cell Rep. 2018. PMID: 29719258 Free article.
PPM1K deficiency led to a notable decrease in MEIS1/p21 signaling to reduce the glycolysis and quiescence of HSCs, followed by a severe impairment in repopulation activities. Moreover, the deletion of Ppm1k dramatically extended survival in a murine leukemia model. …
PPM1K deficiency led to a notable decrease in MEIS1/p21 signaling to reduce the glycolysis and quiescence of HSCs, followed by a seve …
Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.
White PJ, McGarrah RW, Herman MA, Bain JR, Shah SH, Newgard CB. White PJ, et al. Mol Metab. 2021 Oct;52:101261. doi: 10.1016/j.molmet.2021.101261. Epub 2021 May 24. Mol Metab. 2021. PMID: 34044180 Free PMC article. Review.
Feeding of rats with diets enriched in sucrose or fructose result in the induction of the ChREBP transcription factor in the liver to increase expression of the BCKDH kinase (BDK) and suppress the expression of its phosphatase (PPM1K) resulting in the inactivation of BCKDH …
Feeding of rats with diets enriched in sucrose or fructose result in the induction of the ChREBP transcription factor in the liver to increa …
Crystal structure and catalytic activity of the PPM1K N94K mutant.
Dolatabad MR, Guo LL, Xiao P, Zhu Z, He QT, Yang DX, Qu CX, Guo SC, Fu XL, Li RR, Ge L, Hu KJ, Liu HD, Shen YM, Yu X, Sun JP, Zhang PJ. Dolatabad MR, et al. J Neurochem. 2019 Feb;148(4):550-560. doi: 10.1111/jnc.14631. Epub 2019 Jan 3. J Neurochem. 2019. PMID: 30451284 Free article.
PPM1K N94K is an identified missense mutant produced by one of the SNPs in the human PPM1K coding sequence. ...Specifically, three Mg(2+) were located in the active site of the PPM1K N94K instead of two Mg(2+) in the PPM1K wild type. Therefore, our res …
PPM1K N94K is an identified missense mutant produced by one of the SNPs in the human PPM1K coding sequence. ...Specifically, t …
54 results