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GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
Sherpa D, Chrustowicz J, Qiao S, Langlois CR, Hehl LA, Gottemukkala KV, Hansen FM, Karayel O, von Gronau S, Prabu JR, Mann M, Alpi AF, Schulman BA. Sherpa D, et al. Among authors: prabu jr. Mol Cell. 2021 Jun 3;81(11):2445-2459.e13. doi: 10.1016/j.molcel.2021.03.025. Epub 2021 Apr 26. Mol Cell. 2021. PMID: 33905682 Free PMC article.
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BA. Watson ER, et al. Among authors: prabu jr. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17280-17289. doi: 10.1073/pnas.1902889116. Epub 2019 Jul 26. Proc Natl Acad Sci U S A. 2019. PMID: 31350353 Free PMC article.
Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly.
Qiao S, Langlois CR, Chrustowicz J, Sherpa D, Karayel O, Hansen FM, Beier V, von Gronau S, Bollschweiler D, Schäfer T, Alpi AF, Mann M, Prabu JR, Schulman BA. Qiao S, et al. Among authors: prabu jr. Mol Cell. 2020 Jan 2;77(1):150-163.e9. doi: 10.1016/j.molcel.2019.10.009. Epub 2019 Nov 7. Mol Cell. 2020. PMID: 31708416 Free article.
Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klügel M, Scott DC, Ovaa H, Kleiger G, Schulman BA. Horn-Ghetko D, et al. Among authors: prabu jr. Nature. 2021 Feb;590(7847):671-676. doi: 10.1038/s41586-021-03197-9. Epub 2021 Feb 3. Nature. 2021. PMID: 33536622 Free PMC article.
Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases.
Chrustowicz J, Sherpa D, Teyra J, Loke MS, Popowicz GM, Basquin J, Sattler M, Prabu JR, Sidhu SS, Schulman BA. Chrustowicz J, et al. Among authors: prabu jr. J Mol Biol. 2022 Jan 30;434(2):167347. doi: 10.1016/j.jmb.2021.167347. Epub 2021 Nov 9. J Mol Biol. 2022. PMID: 34767800 Free article.
APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain.
Ferguson CJ, Urso O, Bodrug T, Gassaway BM, Watson ER, Prabu JR, Lara-Gonzalez P, Martinez-Chacin RC, Wu DY, Brigatti KW, Puffenberger EG, Taylor CM, Haas-Givler B, Jinks RN, Strauss KA, Desai A, Gabel HW, Gygi SP, Schulman BA, Brown NG, Bonni A. Ferguson CJ, et al. Among authors: prabu jr. Mol Cell. 2022 Jan 6;82(1):90-105.e13. doi: 10.1016/j.molcel.2021.11.031. Epub 2021 Dec 22. Mol Cell. 2022. PMID: 34942119 Free PMC article.
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.
Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Pérez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA. Hehl LA, et al. Among authors: prabu jr. Nat Chem Biol. 2024 Feb;20(2):190-200. doi: 10.1038/s41589-023-01414-2. Epub 2023 Aug 24. Nat Chem Biol. 2024. PMID: 37620400 Free PMC article.
26 results