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Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4.
Okunade GW, Miller ML, Pyne GJ, Sutliff RL, O'Connor KT, Neumann JC, Andringa A, Miller DA, Prasad V, Doetschman T, Paul RJ, Shull GE. Okunade GW, et al. Among authors: prasad v. J Biol Chem. 2004 Aug 6;279(32):33742-50. doi: 10.1074/jbc.M404628200. Epub 2004 Jun 3. J Biol Chem. 2004. PMID: 15178683 Free article.
Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric.
Gawenis LR, Ledoussal C, Judd LM, Prasad V, Alper SL, Stuart-Tilley A, Woo AL, Grisham C, Sanford LP, Doetschman T, Miller ML, Shull GE. Gawenis LR, et al. Among authors: prasad v. J Biol Chem. 2004 Jul 16;279(29):30531-9. doi: 10.1074/jbc.M403779200. Epub 2004 Apr 30. J Biol Chem. 2004. PMID: 15123620 Free article.
Phenotypes of SERCA and PMCA knockout mice.
Prasad V, Okunade GW, Miller ML, Shull GE. Prasad V, et al. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1192-203. doi: 10.1016/j.bbrc.2004.07.156. Biochem Biophys Res Commun. 2004. PMID: 15336967 Review.
Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes.
Okunade GW, Miller ML, Azhar M, Andringa A, Sanford LP, Doetschman T, Prasad V, Shull GE. Okunade GW, et al. Among authors: prasad v. J Biol Chem. 2007 Sep 7;282(36):26517-27. doi: 10.1074/jbc.M703029200. Epub 2007 Jun 27. J Biol Chem. 2007. PMID: 17597066 Free article.
1,930 results