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Page 1
PRDM10 RCC: A Birt-Hogg-Dube-like Syndrome Associated With Lipoma and Highly Penetrant, Aggressive Renal Tumors Morphologically Resembling Type 2 Papillary Renal Cell Carcinoma.
Schmidt LS, Vocke CD, Ricketts CJ, Blake Z, Choo KK, Nielsen D, Gautam R, Crooks DR, Reynolds KL, Krolus JL, Bashyal M, Karim B, Cowen EW, Malayeri AA, Merino MJ, Srinivasan R, Ball MW, Zbar B, Marston Linehan W. Schmidt LS, et al. Urology. 2023 Sep;179:58-70. doi: 10.1016/j.urology.2023.04.035. Epub 2023 Jun 16. Urology. 2023. PMID: 37331486 Free article.
PRDM10 loss of heterozygosity was identified in kidney tumors. PRDM10 was predicted to abrogate expression of FLCN, a transcriptional target of PRDM10, which was confirmed by tumor expression of GPNMB, a TFE3/TFEB target and downstream biomarker of FLCN loss. …
PRDM10 loss of heterozygosity was identified in kidney tumors. PRDM10 was predicted to abrogate expression of FLCN, a transcri …
PRDM10 directs FLCN expression in a novel disorder overlapping with Birt-Hogg-Dube syndrome and familial lipomatosis.
van de Beek I, Glykofridis IE, Oosterwijk JC, van den Akker PC, Diercks GFH, Bolling MC, Waisfisz Q, Mensenkamp AR, Balk JA, Zwart R, Postma AV, Meijers-Heijboer HEJ, van Moorselaar RJA, Wolthuis RMF, Houweling AC. van de Beek I, et al. Hum Mol Genet. 2023 Mar 20;32(7):1223-1235. doi: 10.1093/hmg/ddac288. Hum Mol Genet. 2023. PMID: 36440963 Free PMC article.
By whole exome sequencing we identified a heterozygous missense variant (p.(Cys677Tyr)) in a zinc-finger encoding domain of the PRDM10 gene which co-segregated with the phenotype in the family. ...Overexpressing inducible PRDM10Cys677Tyr in renal epithelial cells altered t …
By whole exome sequencing we identified a heterozygous missense variant (p.(Cys677Tyr)) in a zinc-finger encoding domain of the PRDM10 …
PRDM10-rearranged Soft Tissue Tumor: A Clinicopathologic Study of 9 Cases.
Puls F, Pillay N, Fagman H, Palin-Masreliez A, Amary F, Hansson M, Kindblom LG, McCulloch TA, Meligonis G, Muc R, Rissler P, Sumathi VP, Tirabosco R, Hofvander J, Magnusson L, Nilsson J, Flanagan AM, Mertens F. Puls F, et al. Am J Surg Pathol. 2019 Apr;43(4):504-513. doi: 10.1097/PAS.0000000000001207. Am J Surg Pathol. 2019. PMID: 30570551
Gene fusion transcripts containing PRDM10 were recently identified in low-grade undifferentiated pleomorphic sarcomas (UPS). ...Immunohistochemically, all were CD34 and showed nuclear positivity for PRDM10; focal positivity for cytokeratins was seen in 5/6 cases. …
Gene fusion transcripts containing PRDM10 were recently identified in low-grade undifferentiated pleomorphic sarcomas (UPS). ...Immun …
Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a distinct gene expression profile.
Hofvander J, Puls F, Pillay N, Steele CD, Flanagan AM, Magnusson L, Nilsson J, Mertens F. Hofvander J, et al. J Pathol. 2019 Dec;249(4):425-434. doi: 10.1002/path.5326. Epub 2019 Aug 27. J Pathol. 2019. PMID: 31313299
Undifferentiated pleomorphic sarcoma (UPS) is a highly aggressive soft tissue tumor. A subset of UPS is characterized by a CITED2-PRDM10 or a MED12-PRDM10 gene fusion. Preliminary data suggest that these so-called PRDM10-rearranged tumors (PRT) are clinically …
Undifferentiated pleomorphic sarcoma (UPS) is a highly aggressive soft tissue tumor. A subset of UPS is characterized by a CITED2-PRDM10 …
Autophagy-related LncRNA PRDM10-DT responds to UVB radiation in keratinocytes.
Li L, Hongying C, Heng G. Li L, et al. Biochem Biophys Res Commun. 2023 Oct 15;677:105-112. doi: 10.1016/j.bbrc.2023.08.013. Epub 2023 Aug 7. Biochem Biophys Res Commun. 2023. PMID: 37566921
The expression levels of 80 selected autophagy-related genes and related lncRNAs were confirmed by quantitative real-time polymerase chain reaction (qRT-PCR). The lncRNA PRDM10-DT was proposed to regulate IRGM based on the ceRNA and coexpression pattern and was demonstrate …
The expression levels of 80 selected autophagy-related genes and related lncRNAs were confirmed by quantitative real-time polymerase chain r …
Recurrent PRDM10 Fusions in Superficial CD34-Positive Fibroblastic Tumors : A Clinicopathologic and Molecular Study of 10 Additional Cases of an Emerging Novel Entity.
Zhao M, Yin X, He H, Fan Y, Ru G, Meng X. Zhao M, et al. Am J Clin Pathol. 2023 Apr 4;159(4):367-378. doi: 10.1093/ajcp/aqac171. Am J Clin Pathol. 2023. PMID: 36812381
All tumors expressed CD34, and 4 demonstrated focal cytokeratin immunoexpression. In 7 of 9 (77.8%) cases analyzed, FISH identified PRDM10 rearrangement. Targeted NGS revealed a MED12::PRDM10 fusion in 4 of 7 cases tested. Follow-up showed no recurrence or metastasi …
All tumors expressed CD34, and 4 demonstrated focal cytokeratin immunoexpression. In 7 of 9 (77.8%) cases analyzed, FISH identified PRDM1 …
Recurrent PRDM10 gene fusions in undifferentiated pleomorphic sarcoma.
Hofvander J, Tayebwa J, Nilsson J, Magnusson L, Brosjö O, Larsson O, Vult von Steyern F, Mandahl N, Fletcher CD, Mertens F. Hofvander J, et al. Clin Cancer Res. 2015 Feb 15;21(4):864-9. doi: 10.1158/1078-0432.CCR-14-2399. Epub 2014 Dec 16. Clin Cancer Res. 2015. PMID: 25516889
Further screening of 82 soft tissue sarcomas for rearrangements of the PRDM10 locus revealed one more UPS with a MED12/PRDM10 fusion. None of these genes has been implicated in neoplasia-associated gene fusions before. ...Thus, PRDM10 fusion-positive sarcomas …
Further screening of 82 soft tissue sarcomas for rearrangements of the PRDM10 locus revealed one more UPS with a MED12/PRDM10 …
Global translation during early development depends on the essential transcription factor PRDM10.
Han BY, Seah MKY, Brooks IR, Quek DHP, Huxley DR, Foo CS, Lee LT, Wollmann H, Guo H, Messerschmidt DM, Guccione E. Han BY, et al. Nat Commun. 2020 Jul 17;11(1):3603. doi: 10.1038/s41467-020-17304-3. Nat Commun. 2020. PMID: 32681107 Free PMC article.
Here, we report an essential requirement for PRDM10 in pre-implantation embryos and embryonic stem cells (mESCs), where loss of PRDM10 results in severe cell growth inhibition. Detailed genomic and biochemical analyses reveal that PRDM10 functions as a sequen …
Here, we report an essential requirement for PRDM10 in pre-implantation embryos and embryonic stem cells (mESCs), where loss of PR …
Investigation of PRDM10 and PRDM13 Expression in Developing Mouse Embryos by an Optimized PACT-Based Embryo Clearing Method.
Woo J, Jin BH, Lee M, Lee EY, Moon HS, Park JY, Cho YE. Woo J, et al. Int J Mol Sci. 2021 Mar 12;22(6):2892. doi: 10.3390/ijms22062892. Int J Mol Sci. 2021. PMID: 33809237 Free PMC article.
We demonstrate proof-of-concept by investigating the expression of two relatively understudied PR domain (PRDM) proteins, PRDM10 and PRDM13, in intact cleared mouse embryos at various stages of development. We observed strong PRDM10 and PRDM13 expression in the deve …
We demonstrate proof-of-concept by investigating the expression of two relatively understudied PR domain (PRDM) proteins, PRDM10 and …
Overlapping morphological, immunohistochemical and genetic features of superficial CD34-positive fibroblastic tumor and PRDM10-rearranged soft tissue tumor.
Puls F, Carter JM, Pillay N, McCulloch TA, Sumathi VP, Rissler P, Fagman H, Hansson M, Amary F, Tirabosco R, Magnusson L, Nilsson J, Flanagan AM, Folpe AL, Mertens F. Puls F, et al. Mod Pathol. 2022 Jun;35(6):767-776. doi: 10.1038/s41379-021-00991-8. Epub 2021 Dec 30. Mod Pathol. 2022. PMID: 34969957 Free article.
The pathogenesis of this tumor remains incompletely understood, but it has been suggested that SCD34FT overlaps with tumors showing fusions involving the PRDM10 gene. Previous analyses of PRDM10-rearranged tumors have demonstrated that they have a distinct gene expr …
The pathogenesis of this tumor remains incompletely understood, but it has been suggested that SCD34FT overlaps with tumors showing fusions …
50 results