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Year Number of Results
2013 3
2014 2
2015 3
2016 2
2017 2
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2019 1
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Loss of PRDM11 promotes MYC-driven lymphomagenesis.
Fog CK, Asmar F, Côme C, Jensen KT, Johansen JV, Kheir TB, Jacobsen L, Friis C, Louw A, Rosgaard L, Øbro NF, Marquart HV, Anthonsen K, Braat AK, van Lohuizen M, Ralfkiaer E, Grønbæk K, Lund AH. Fog CK, et al. Blood. 2015 Feb 19;125(8):1272-81. doi: 10.1182/blood-2014-03-560805. Epub 2014 Dec 12. Blood. 2015. PMID: 25499759 Free article.
Here we demonstrate oncogenic collaboration between depletion of the previously uncharacterized PR-domain family member Prdm11 and overexpression of MYC. Overexpression of PRDM11 inhibits proliferation and induces apoptosis. Prdm11 knockout mice are viable, a …
Here we demonstrate oncogenic collaboration between depletion of the previously uncharacterized PR-domain family member Prdm11 and ov …
PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells.
Thoren LA, Fog CK, Jensen KT, Buza-Vidas N, Côme C, Lund AH, Porse BT. Thoren LA, et al. Stem Cell Res. 2013 Nov;11(3):1129-36. doi: 10.1016/j.scr.2013.07.009. Epub 2013 Aug 9. Stem Cell Res. 2013. PMID: 23978475 Free article.
Therefore, we undertook experiments to test if PRDM11 regulates HSC self-renewal, maintenance and function by investigating the Prdm11(-/-) mice. Our data shows that phenotypic HSPCs are intact in bone marrow (BM) of one-year-old Prdm11(-/-) mice. In addition …
Therefore, we undertook experiments to test if PRDM11 regulates HSC self-renewal, maintenance and function by investigating the Pr
MicroRNA-2400 promotes bovine preadipocyte proliferation.
Wei Y, Cui YF, Tong HL, Zhang WW, Yan YQ. Wei Y, et al. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1054-9. doi: 10.1016/j.bbrc.2016.08.038. Epub 2016 Aug 8. Biochem Biophys Res Commun. 2016. PMID: 27514450
Furthermore, luciferase reporter assays showed that miR-2400 bound directly to the 3'untranslated regions (3'UTRs) of PRDM11 mRNA. These data suggested that miR-2400 could promote preadipocyte proliferation by targeting PRDM11....
Furthermore, luciferase reporter assays showed that miR-2400 bound directly to the 3'untranslated regions (3'UTRs) of PRDM11 mRNA. Th …
Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines.
Horsch M, Aguilar-Pimentel JA, Bönisch C, Côme C, Kolster-Fog C, Jensen KT, Lund AH, Lee I, Grossman LI, Sinkler C, Hüttemann M, Bohn E, Fuchs H, Ollert M, Gailus-Durner V, de Angelis MH, Beckers J. Horsch M, et al. PLoS One. 2015 Aug 11;10(8):e0134503. doi: 10.1371/journal.pone.0134503. eCollection 2015. PLoS One. 2015. PMID: 26263558 Free PMC article.
Evolution of Prdm Genes in Animals: Insights from Comparative Genomics.
Vervoort M, Meulemeester D, Béhague J, Kerner P. Vervoort M, et al. Mol Biol Evol. 2016 Mar;33(3):679-96. doi: 10.1093/molbev/msv260. Epub 2015 Nov 11. Mol Biol Evol. 2016. PMID: 26560352 Free PMC article.
Three additional subfamilies were acquired during early vertebrate evolution (Prdm5, Prdm11, and Prdm17). Several gene duplication and gene loss events were identified and mapped onto the metazoan phylogenetic tree. ...
Three additional subfamilies were acquired during early vertebrate evolution (Prdm5, Prdm11, and Prdm17). Several gene duplication an …
Chromatin Regulator-Related Gene Signature for Predicting Prognosis and Immunotherapy Efficacy in Breast Cancer.
Feng D, Li W, Wu W, Kahlert UD, Gao P, Hu G, Huang X, Shi W, Li H. Feng D, et al. J Oncol. 2023 Jan 30;2023:2736932. doi: 10.1155/2023/2736932. eCollection 2023. J Oncol. 2023. PMID: 36755810 Free PMC article.
RESULTS: We identified 98 CR-related DEGs in breast tissues and constructed a novel 6 CR-related gene signature (ARID5A, ASCL1, IKZF3, KDM4B, PRDM11, and TFF1) to predict the outcome of BC patients. The prognostic value of this CR-related gene signature was validated with …
RESULTS: We identified 98 CR-related DEGs in breast tissues and constructed a novel 6 CR-related gene signature (ARID5A, ASCL1, IKZF3, KDM4B …
Artificial-Intelligence-Assisted Discovery of Genetic Factors for Precision Medicine of Antiplatelet Therapy in Diabetic Peripheral Artery Disease.
Yeh CH, Chou YJ, Tsai TH, Hsu PW, Li CH, Chan YH, Tsai SF, Ng SC, Chou KM, Lin YC, Juan YH, Fu TC, Lai CC, Sytwu HK, Tsai TF. Yeh CH, et al. Biomedicines. 2022 Jan 6;10(1):116. doi: 10.3390/biomedicines10010116. Biomedicines. 2022. PMID: 35052795 Free PMC article.
Secondly, AI-assisted genome-wide association study of a single-nucleotide polymorphism (SNP) database identified a SNP signature composed of 20 SNPs, which are mapped into 9 protein-coding genes (SLC37A2, IQSEC1, WASHC3, PSD3, BTBD7, GLIS3, PRDM11, LRBA1, and CNR1). Final …
Secondly, AI-assisted genome-wide association study of a single-nucleotide polymorphism (SNP) database identified a SNP signature composed o …
Associated regions for multiple birth in Brown Swiss and Original Braunvieh cattle on chromosomes 15 and 11.
Widmer S, Seefried FR, von Rohr P, Häfliger IM, Spengeler M, Drögemüller C. Widmer S, et al. Anim Genet. 2022 Oct;53(5):557-569. doi: 10.1111/age.13229. Epub 2022 Jun 24. Anim Genet. 2022. PMID: 35748198 Free PMC article.
A presumably regulatory variant in the non-coding 5' region of the ID2 gene was strongly associated with the haplotype for Original Braunvieh. In Brown Swiss, an intron variant in PRDM11, one 3' UTR variant in SYT13 and three intergenic variants 5' upstream of SYT13 were i …
A presumably regulatory variant in the non-coding 5' region of the ID2 gene was strongly associated with the haplotype for Original Braunvie …
Identification of potential cancer-related pseudogenes in lung adenocarcinoma based on ceRNA hypothesis.
Wei Y, Chang Z, Wu C, Zhu Y, Li K, Xu Y. Wei Y, et al. Oncotarget. 2017 Aug 4;8(35):59036-59047. doi: 10.18632/oncotarget.19933. eCollection 2017 Aug 29. Oncotarget. 2017. PMID: 28938616 Free PMC article.
We further revealed that the 3 ceRNA triples (miR-21-5p-NKAPP1-PRDM11, miR-29c-3p-MSTO2P-EZH2 and miR-29c-3p-RPLP0P2-EZH2), whose high risk groups were associated with the poor prognosis of LUAD, may be considered as potential prognostic signatures. ...
We further revealed that the 3 ceRNA triples (miR-21-5p-NKAPP1-PRDM11, miR-29c-3p-MSTO2P-EZH2 and miR-29c-3p-RPLP0P2-EZH2), whose hig …
Genome-wide association analysis identifies six new loci associated with forced vital capacity.
Loth DW, Soler Artigas M, Gharib SA, Wain LV, Franceschini N, Koch B, Pottinger TD, Smith AV, Duan Q, Oldmeadow C, Lee MK, Strachan DP, James AL, Huffman JE, Vitart V, Ramasamy A, Wareham NJ, Kaprio J, Wang XQ, Trochet H, Kähönen M, Flexeder C, Albrecht E, Lopez LM, de Jong K, Thyagarajan B, Alves AC, Enroth S, Omenaas E, Joshi PK, Fall T, Viñuela A, Launer LJ, Loehr LR, Fornage M, Li G, Wilk JB, Tang W, Manichaikul A, Lahousse L, Harris TB, North KE, Rudnicka AR, Hui J, Gu X, Lumley T, Wright AF, Hastie ND, Campbell S, Kumar R, Pin I, Scott RA, Pietiläinen KH, Surakka I, Liu Y, Holliday EG, Schulz H, Heinrich J, Davies G, Vonk JM, Wojczynski M, Pouta A, Johansson A, Wild SH, Ingelsson E, Rivadeneira F, Völzke H, Hysi PG, Eiriksdottir G, Morrison AC, Rotter JI, Gao W, Postma DS, White WB, Rich SS, Hofman A, Aspelund T, Couper D, Smith LJ, Psaty BM, Lohman K, Burchard EG, Uitterlinden AG, Garcia M, Joubert BR, McArdle WL, Musk AB, Hansel N, Heckbert SR, Zgaga L, van Meurs JB, Navarro P, Rudan I, Oh YM, Redline S, Jarvis DL, Zhao JH, Rantanen T, O'Connor GT, Ripatti S, Scott RJ, Karrasch S, Grallert H, Gaddis NC, Starr JM, Wijmenga C, Minster RL, Lederer DJ, Pekkanen J, Gyllensten U… See abstract for full author list ➔ Loth DW, et al. Nat Genet. 2014 Jul;46(7):669-77. doi: 10.1038/ng.3011. Epub 2014 Jun 15. Nat Genet. 2014. PMID: 24929828 Free PMC article.
We found six new regions associated at genome-wide significance (P < 5 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. ...

We found six new regions associated at genome-wide significance (P < 5 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PR

14 results