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Predictors of Initial Presentation with Hemorrhage in Patients with Cavernous Malformations.
Flemming KD, Kumar S, Brown RD Jr, Lanzino G. Flemming KD, et al. World Neurosurg. 2020 Jan;133:e767-e773. doi: 10.1016/j.wneu.2019.09.161. Epub 2019 Oct 9. World Neurosurg. 2020. PMID: 31605843
BACKGROUND: Cavernous malformations (CMs) are low-flow vascular malformations of the central nervous system which are incidental or present with hemorrhage, seizures, or focal neurologic deficit (FND). ...Brainstem location correlated with a hig …
BACKGROUND: Cavernous malformations (CMs) are low-flow vascular malformations of the central nervous system which are i …
Hemorrhage from cerebral cavernous malformations: The role of associated developmental venous anomalies.
Chen B, Herten A, Saban D, Rauscher S, Radbruch A, Schmidt B, Zhu Y, Jabbarli R, Wrede KH, Kleinschnitz C, Sure U, Dammann P. Chen B, et al. Neurology. 2020 Jul 7;95(1):e89-e96. doi: 10.1212/WNL.0000000000009730. Epub 2020 Jun 8. Neurology. 2020. PMID: 32513786
OBJECTIVE: To determine the role of associated developmental venous anomalies (DVAs) in intracranial hemorrhage (ICH) caused by cerebral cavernous malformations (CCMs). METHODS: We analyzed patient registry data of 1,219 patients with caverno
OBJECTIVE: To determine the role of associated developmental venous anomalies (DVAs) in intracranial hemorrhage (ICH) caused by cereb …
Cavernous Malformation Hemorrhagic Presentation at Diagnosis Associated with Low 25-Hydroxy-Vitamin D Level.
Flemming KD, Kumar S, Brown RD Jr, Singh RJ, Whitehead K, McCreath L, Lanzino G. Flemming KD, et al. Cerebrovasc Dis. 2020;49(2):216-222. doi: 10.1159/000507789. Epub 2020 Apr 29. Cerebrovasc Dis. 2020. PMID: 32348981 Free article.
After adjusting for age, month of blood draw, and body mass index, 25-hydroxy-vitamin D remained a significant predictor of hemorrhagic presentation. Brainstem location also predicted hemorrhage at presentation. CONCLUSION: Low 25-hydroxy …
After adjusting for age, month of blood draw, and body mass index, 25-hydroxy-vitamin D remained a significant predictor of …
Clinical course of untreated thalamic cavernous malformations: hemorrhage risk and neurological outcomes.
Tian KB, Zheng JJ, Ma JP, Hao SY, Wang L, Zhang LW, Wu Z, Zhang JT, Li D. Tian KB, et al. J Neurosurg. 2017 Sep;127(3):480-491. doi: 10.3171/2016.8.JNS16934. Epub 2016 Nov 11. J Neurosurg. 2017. PMID: 27834594
The overall annual hemorrhage rate (subsequent to the initial presentation) was calculated to be 9.7% based on the occurrence of 42 hemorrhages over 433.1 patient-years. This rate was highest in patients (n = 87) who initially p
The overall annual hemorrhage rate (subsequent to the initial presentation) was calculated to be 9.7% based on the occu …
Hemorrhage risks and functional outcomes of untreated brainstem cavernous malformations.
Li D, Hao SY, Jia GJ, Wu Z, Zhang LW, Zhang JT. Li D, et al. J Neurosurg. 2014 Jul;121(1):32-41. doi: 10.3171/2014.3.JNS132537. Epub 2014 May 2. J Neurosurg. 2014. PMID: 24785325
However, the annual hemorrhage rate was 8.7% in patients initially presenting without hemorrhage (n = 82). ...CONCLUSIONS: Patients' initial presentation predicts their prospective annual hemorrhage rate. ...
However, the annual hemorrhage rate was 8.7% in patients initially presenting without hemorrhage (n = 82) …
Natural course of untreated spinal cord cavernous malformations: a follow-up study within the initial 5 years after diagnosis.
Santos AN, Rauschenbach L, Darkwah Oppong M, Gembruch O, Saban D, Chen B, Herten A, Schmidt B, Li Y, Özkan N, Jabbarli R, Wrede K, Sure U, Dammann P. Santos AN, et al. J Neurosurg Spine. 2021 Dec 17;36(6):1030-1034. doi: 10.3171/2021.9.SPINE211052. Print 2022 Jun 1. J Neurosurg Spine. 2021. PMID: 34920423
The MMcC score significantly deteriorated in 75% of patients after recurrent hemorrhage (p = 0.012). CONCLUSIONS: During untreated 5-year follow-up, a considerably increased risk for hemorrhage or rehemorrhage was found in cavernous malformations
The MMcC score significantly deteriorated in 75% of patients after recurrent hemorrhage (p = 0.012). CONCLUSIONS: During untre …