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A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin.
Liu W, Zi M, Tsui H, Chowdhury SK, Zeef L, Meng QJ, Travis M, Prehar S, Berry A, Hanley NA, Neyses L, Xiao RP, Oceandy D, Ke Y, Solaro RJ, Cartwright EJ, Lei M, Wang X. Liu W, et al. Among authors: prehar s. Circ Heart Fail. 2013 Jul;6(4):833-44. doi: 10.1161/CIRCHEARTFAILURE.112.000123. Epub 2013 Jun 10. Circ Heart Fail. 2013. PMID: 23753531 Free PMC article.
The cardiovascular phenotype of a mouse model of acromegaly.
Izzard AS, Emerson M, Prehar S, Neyses L, Trainer P, List EO, Kopchick JJ, Heagerty AM. Izzard AS, et al. Among authors: prehar s. Growth Horm IGF Res. 2009 Oct;19(5):413-9. doi: 10.1016/j.ghir.2008.12.006. Epub 2009 Mar 9. Growth Horm IGF Res. 2009. PMID: 19269870
Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium.
Mohamed TM, Oceandy D, Prehar S, Alatwi N, Hegab Z, Baudoin FM, Pickard A, Zaki AO, Nadif R, Cartwright EJ, Neyses L. Mohamed TM, et al. Among authors: prehar s. J Biol Chem. 2009 May 1;284(18):12091-8. doi: 10.1074/jbc.M809112200. Epub 2009 Mar 10. J Biol Chem. 2009. PMID: 19278978 Free PMC article.
Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis.
Zi M, Kimura TE, Liu W, Jin J, Higham J, Kharche S, Hao G, Shi Y, Shen W, Prehar S, Mironov A, Neyses L, Bierhuizen MF, Boyett MR, Zhang H, Lei M, Cartwright EJ, Wang X. Zi M, et al. Among authors: prehar s. J Biol Chem. 2011 May 20;286(20):17821-30. doi: 10.1074/jbc.M111.228791. Epub 2011 Mar 28. J Biol Chem. 2011. PMID: 21454599 Free PMC article. No abstract available.
Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.
Mohamed TMA, Oceandy D, Zi M, Prehar S, Alatwi N, Wang Y, Shaheen MA, Abou-Leisa R, Schelcher C, Hegab Z, Baudoin F, Emerson M, Mamas M, Di Benedetto G, Zaccolo M, Lei M, Cartwright EJ, Neyses L. Mohamed TMA, et al. Among authors: prehar s. J Biol Chem. 2011 Dec 2;286(48):41520-41529. doi: 10.1074/jbc.M111.290411. Epub 2011 Sep 29. J Biol Chem. 2011. PMID: 21965681 Free PMC article.
36 results