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Year Number of Results
1992 1
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1997 1
1998 2
1999 3
2000 5
2001 3
2002 4
2003 1
2004 5
2005 2
2006 7
2007 9
2008 5
2009 4
2010 7
2011 13
2012 8
2013 8
2014 5
2015 8
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2017 6
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169 results

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Page 1
PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression.
Li Z, Chen C, Yong H, Jiang L, Wang P, Meng S, Chu S, Li Z, Guo Q, Zheng J, Bai J, Li H. Li Z, et al. Cell Death Dis. 2023 May 12;14(5):322. doi: 10.1038/s41419-023-05837-6. Cell Death Dis. 2023. PMID: 37173306 Free PMC article.
Here, we found that PRMT2 was upregulated in primary RCC and RCC cell lines. We demonstrated that PRMT2 overexpression promoted RCC cell proliferation and motility both in vitro and in vivo. ...Our study also suggests that PRMT2 is a novel therapeutic target …
Here, we found that PRMT2 was upregulated in primary RCC and RCC cell lines. We demonstrated that PRMT2 overexpression promote …
Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair.
Liu L, Lin B, Yin S, Ball LE, Delaney JR, Long DT, Gan W. Liu L, et al. Sci Adv. 2022 Dec 9;8(49):eadd8928. doi: 10.1126/sciadv.add8928. Epub 2022 Dec 7. Sci Adv. 2022. PMID: 36475791 Free PMC article.
Specifically, PRMT2/4 interacts with and methylates BRD4 at R179, R181, and R183. ...Therefore, our findings reveal an arginine methylation-dependent regulatory mechanism of BRD4 and highlight targeting PRMT2/4 for better antitumor effect of BET inhibitors and DNA d …
Specifically, PRMT2/4 interacts with and methylates BRD4 at R179, R181, and R183. ...Therefore, our findings reveal an arginine methy …
Structure, Activity and Function of the PRMT2 Protein Arginine Methyltransferase.
Cura V, Cavarelli J. Cura V, et al. Life (Basel). 2021 Nov 19;11(11):1263. doi: 10.3390/life11111263. Life (Basel). 2021. PMID: 34833139 Free PMC article. Review.
PRMT2 contains the canonical PRMT methylation core and a unique Src homology 3 domain. ...Furthermore, PRMT2 is aberrantly expressed in several cancer types, including breast cancer and glioblastoma. ...
PRMT2 contains the canonical PRMT methylation core and a unique Src homology 3 domain. ...Furthermore, PRMT2 is aberrantly exp …
PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex.
Jin J, Bai H, Yan H, Deng T, Li T, Xiao R, Fan L, Bai X, Ning H, Liu Z, Zhang K, Wu X, Liang K, Ma P, Gao X, Hu D. Jin J, et al. Nat Commun. 2023 Nov 10;14(1):7274. doi: 10.1038/s41467-023-43060-1. Nat Commun. 2023. PMID: 37949879 Free PMC article.
Here, through a targeted complementary DNA (cDNA) expression screening, we identify PRMT2 as a key suppressor of Tat activation, thus contributing to proviral latency in multiple cell line latency models and in HIV-1-infected patient CD4(+) T cells. ...Thus, our studies un …
Here, through a targeted complementary DNA (cDNA) expression screening, we identify PRMT2 as a key suppressor of Tat activation, thus …
Hypoxia-inducible PRMT2 addiction in glioblastomas.
Dong F, Sun X, Su J, Li Q, He Y, Li W, Wang B, Wang B, Xu G, Wu X. Dong F, et al. Cell Signal. 2024 May;117:111094. doi: 10.1016/j.cellsig.2024.111094. Epub 2024 Feb 8. Cell Signal. 2024. PMID: 38341123
And we established a connection between PRMT2-mediated histone H3R8 asymmetric methylation (H3R8me2a) and transcription activation. Here we find that PRMT2 is activated by HIF1alpha under hypoxic conditions. And we demonstrate that PRMT2 and its H3R8me2a acti …
And we established a connection between PRMT2-mediated histone H3R8 asymmetric methylation (H3R8me2a) and transcription activation. H …
PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation.
Hu G, Yan C, Xie P, Cao Y, Shao J, Ge J. Hu G, et al. Exp Cell Res. 2020 Sep 15;394(2):112152. doi: 10.1016/j.yexcr.2020.112152. Epub 2020 Jun 21. Exp Cell Res. 2020. PMID: 32574605
However, the expression and role of PRMT2 in hepatocellular carcinoma (HCC) have not been studied. Here, we discovered that PRMT2 expression is elevated in HCC tissues compared to the corresponding non-tumor tissues, and PRMT2 overexpression is an independent …
However, the expression and role of PRMT2 in hepatocellular carcinoma (HCC) have not been studied. Here, we discovered that PRMT2 …
Zebrafish prmt2 Attenuates Antiviral Innate Immunity by Targeting traf6.
Zhu J, Li X, Sun X, Zhou Z, Cai X, Liu X, Wang J, Xiao W. Zhu J, et al. J Immunol. 2021 Nov 15;207(10):2570-2580. doi: 10.4049/jimmunol.2100627. Epub 2021 Oct 15. J Immunol. 2021. PMID: 34654690
In addition, it seems that the N terminus of prmt2 competes with mavs for traf6 binding and prevents the recruitment of tbk1/ikkepsilon to mavs. ...Therefore, we reveal, to our knowledge, a novel function of prmt2 in the negative regulation of antiviral innate immun …
In addition, it seems that the N terminus of prmt2 competes with mavs for traf6 binding and prevents the recruitment of tbk1/ikkepsil …
PRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6.
Liu T, Li Y, Xu M, Huang H, Luo Y. Liu T, et al. BMC Immunol. 2024 Jan 3;25(1):1. doi: 10.1186/s12865-023-00593-w. BMC Immunol. 2024. PMID: 38172698 Free PMC article.
However, the role of PRMT2 in M1/M2 macrophage polarization remains unclear. Our study revealed the effect and mechanism of PRMT2 in macrophage polarization. ...CONCLUSIONS: PRMT2 silencing modulates macrophage polarization by activating STAT1 to promote M1 a …
However, the role of PRMT2 in M1/M2 macrophage polarization remains unclear. Our study revealed the effect and mechanism of PRMT2 …
Loss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic mice.
Vurusaner B, Thevkar-Nages P, Kaur R, Giannarelli C, Garabedian MJ, Fisher EA. Vurusaner B, et al. Sci Rep. 2022 Jul 14;12(1):12031. doi: 10.1038/s41598-022-15349-6. Sci Rep. 2022. PMID: 35835907 Free PMC article.
PRMT2 catalyzes arginine methylation to target proteins to modulate gene expression. Because PRMT2 expression is reduced in cells in hyperglycemia, we wanted to determine whether PRMT2 plays a causal role in the impairment of atherosclerosis regression in dia …
PRMT2 catalyzes arginine methylation to target proteins to modulate gene expression. Because PRMT2 expression is reduced in ce …
PRMT2 inhibits the formation of foam cell induced by ox-LDL in RAW 264.7 macrophage involving ABCA1 mediated cholesterol efflux.
Li YY, Zhou SH, Chen SS, Zhong J, Wen GB. Li YY, et al. Biochem Biophys Res Commun. 2020 Mar 26;524(1):77-82. doi: 10.1016/j.bbrc.2020.01.040. Epub 2020 Jan 21. Biochem Biophys Res Commun. 2020. PMID: 31980179
METHODS: Lentivirus vector of overexpression PRMT2 (LV-PRMT2) was constructed. LV-PRMT2 and lentivirus vector GV492 were transfected into RAW 264.7 macrophages, positive clone cells were screened by treatment with 4.0 mug/mL puromycin for 4 weeks. ...Compared …
METHODS: Lentivirus vector of overexpression PRMT2 (LV-PRMT2) was constructed. LV-PRMT2 and lentivirus vector GV492 wer …
169 results