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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1981 2
1982 1
1984 8
1985 6
1986 8
1987 8
1988 6
1989 11
1990 7
1991 8
1992 6
1993 4
1994 16
1995 8
1996 11
1997 14
1998 17
1999 17
2000 9
2001 5
2002 13
2003 12
2004 7
2005 6
2006 15
2007 14
2008 6
2009 6
2010 9
2011 7
2012 6
2013 6
2014 4
2015 2
2016 1
2017 2
2018 2
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2020 3
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2022 3
2023 1
2024 2

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293 results

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Page 1
L-2-oxothiazolidine-4-carboxylic acid (procysteine) inhibits expression of the human immunodeficiency virus and expression of the interleukin-2 receptor alpha chain.
Lederman MM, Georges D, Dando S, Schmelzer R, Averill L, Goldberg D. Lederman MM, et al. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):107-15. J Acquir Immune Defic Syndr Hum Retrovirol. 1995. PMID: 7834394
These studies were undertaken to examine the in vitro effects of the cysteine pro-drug L-2-oxothiazolidine-4-carboxylic acid (Procysteine) on human immunodeficiency virus expression. ...Gel-shift assays showed that Procysteine inhi …
These studies were undertaken to examine the in vitro effects of the cysteine pro-drug L-2-oxothiazolidine-4-carboxy …
L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium.
Promsote W, Veeranan-Karmegam R, Ananth S, Shen D, Chan CC, Lambert NA, Ganapathy V, Martin PM. Promsote W, et al. Mol Vis. 2014 Jan 7;20:73-88. eCollection 2014. Mol Vis. 2014. PMID: 24426777 Free PMC article.
We reported previously on the robust antioxidant and therefore cell-protective effects of the cysteine pro-drug L-2-oxothiazolidine-4-carboxylic acid (OTC) in cultured human RPE cells. ...
We reported previously on the robust antioxidant and therefore cell-protective effects of the cysteine pro-drug L-2-oxothiazolidin …
Determination of L-2-oxothiazolidine-4-carboxylic acid (Procysteine) in human plasma by high-performance liquid chromatography.
Webb LE, Gechman M, Story K. Webb LE, et al. J Chromatogr B Biomed Appl. 1994 Apr 1;654(2):257-62. doi: 10.1016/0378-4347(94)00021-2. J Chromatogr B Biomed Appl. 1994. PMID: 8044286
A new high-performance liquid chromatographic (HPLC) method has been developed for the determination of the cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid (Procysteine), in human plasma. ...Procysteine was detected spectro …
A new high-performance liquid chromatographic (HPLC) method has been developed for the determination of the cysteine prodrug, L-2- …
Elevation of whole-blood glutathione in peritoneal dialysis patients by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug (Procysteine).
Moberly JB, Logan J, Borum PR, Story KO, Webb LE, Jassal SV, Mupas L, Rodela H, Alghamdi GA, Moran JE, Wolfson M, Martis L, Oreopoulos DG. Moberly JB, et al. J Am Soc Nephrol. 1998 Jun;9(6):1093-9. doi: 10.1681/ASN.V961093. J Am Soc Nephrol. 1998. PMID: 9621294 Clinical Trial.
It has been reported previously that patients undergoing dialysis have low levels of blood glutathione, which may lead to increased susceptibility to oxidant stress. L-2-oxothiazolidine-4-carboxylic acid (OTZ) is a cysteine prodrug that raises c …
It has been reported previously that patients undergoing dialysis have low levels of blood glutathione, which may lead to increased suscepti …
L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease.
Vita JA, Frei B, Holbrook M, Gokce N, Leaf C, Keaney JF Jr. Vita JA, et al. J Clin Invest. 1998 Mar 15;101(6):1408-14. doi: 10.1172/JCI1155. J Clin Invest. 1998. PMID: 9502783 Free PMC article. Clinical Trial.
This impairment has been attributed in part to increased vascular oxidative stress. EDNO action is improved by administration of ascorbic acid, a water-soluble antioxidant. Ascorbic acid is a potent free-radical scavenger in plasma, and also regulates intracellular …
This impairment has been attributed in part to increased vascular oxidative stress. EDNO action is improved by administration of ascorbic …
Synthesis of L-2-oxothiazolidine-4-carboxylic acid.
Boettcher B, Meister A. Boettcher B, et al. Anal Biochem. 1984 May 1;138(2):449-50. doi: 10.1016/0003-2697(84)90837-6. Anal Biochem. 1984. PMID: 6742422
An improved synthesis of L-2- oxothiazolidine -4-carboxylic acid is described. The new procedure, which leads to excellent yields of product, does not require the use of phosgene. ...
An improved synthesis of L-2- oxothiazolidine -4-carboxylic acid is described. The new procedure, which l …
Supplementation with L-2-oxothiazolidine-4-carboxylic acid, a cysteine precursor, does not protect against lipid peroxidation in puromycin aminonucleoside-induced nephropathy.
Fawcett JP, Schiller B, Jiang R, Moran J, Walker RJ. Fawcett JP, et al. Exp Nephrol. 1996 Jul-Aug;4(4):248-52. Exp Nephrol. 1996. PMID: 8864728
Lipid peroxidation in the kidney has been shown to precede proteinuria in puromycin aminonucleoside (PAN)-induced nephropathy. The aim of this study was to determine if L-2-oxothiazolidine-4-carboxylic acid (procysteine) would protect rat …
Lipid peroxidation in the kidney has been shown to precede proteinuria in puromycin aminonucleoside (PAN)-induced nephropathy. The aim of th …
L-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products.
Breborowicz A, Witowski J, Polubinska A, Pyda M, Oreopoulos D. Breborowicz A, et al. Nephrol Dial Transplant. 2004 Dec;19(12):3005-11. doi: 10.1093/ndt/gfh539. Epub 2004 Oct 26. Nephrol Dial Transplant. 2004. PMID: 15507476
Several approaches have been proposed to reduce the content or toxicity, or both, of GDP present in the dialysis fluid. We examined whether L-2-oxothiazolidine-4-carboxylic acid (OTZ), a precursor for glutathione synthesis, reduces the cytotoxic …
Several approaches have been proposed to reduce the content or toxicity, or both, of GDP present in the dialysis fluid. We examined whether …
Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury.
Lee S, Moon SO, Kim W, Sung MJ, Kim DH, Kang KP, Jang YB, Lee JE, Jang KY, Lee SY, Park SK. Lee S, et al. Nephrol Dial Transplant. 2006 Aug;21(8):2085-95. doi: 10.1093/ndt/gfl209. Epub 2006 May 16. Nephrol Dial Transplant. 2006. PMID: 16705027
BACKGROUND: Oxidative stress and inflammation are implicated in the pathogenesis of cisplatin-induced nephrotoxicity. l-2-oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug, and increases cellular glutathione (GSH). ...Nuclear factor …
BACKGROUND: Oxidative stress and inflammation are implicated in the pathogenesis of cisplatin-induced nephrotoxicity. l-2-oxothiaz …
293 results