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Proliferation-associated long noncoding RNA, TMPO-AS1, is a potential therapeutic target for triple-negative breast cancer.
Mitobe Y, Ikeda K, Sato W, Kodama Y, Naito M, Gotoh N, Miyata K, Kataoka K, Sasaki H, Horie-Inoue K, Inoue S. Mitobe Y, et al. Cancer Sci. 2020 Jul;111(7):2440-2450. doi: 10.1111/cas.14498. Epub 2020 Jun 13. Cancer Sci. 2020. PMID: 32437068 Free PMC article.
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer compared with luminal or epidermal growth factor receptor 2 subtypes, thus effective therapeutic options for TNBC are yet to be developed. ...We here showed that TMPO-AS1 is abundantly ex …
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer compared with luminal or epidermal growth facto …
Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy.
Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, Nagano O. Otsuki Y, et al. Cancer Sci. 2020 Jan;111(1):127-136. doi: 10.1111/cas.14224. Epub 2019 Nov 22. Cancer Sci. 2020. PMID: 31692172 Free PMC article.
Furthermore, OXY-mediated ALDH inhibition was found to sensitize cancer cells to GSH depletion induced by radiation therapy in vitro. Our findings thus establish a rationale for repurposing of OXY as a sensitizing drug for cancer treatment with agents that induce GS …
Furthermore, OXY-mediated ALDH inhibition was found to sensitize cancer cells to GSH depletion induced by radiation therapy in vitro. …